Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

Abbott, Timothy R; Dhamdhere, Girija; Liu, Yanxia; Lin, Xueqiu; Goudy, Laine; Zeng, Leiping; Chemparathy, Augustine; Chmura, Stephen; Heaton, Nicholas S; Debs, Robert; Pande, Tara; Endy, Drew; La Russa, Marie F; Lewis, David B; Qi, Lei S.

Cell ; 181(4): 865-876.e12, 2020 05 14.

Artigo em Inglês | MEDLINE | ID: mdl-32353252

2.

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression.

Munir, Moiz; Embry, Aaron; Doench, John G; Heaton, Nicholas S; Wilen, Craig B; Orchard, Robert C.

J Biol Chem ; 300(4): 107153, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38462163

3.

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Heaton, Nicholas S; Moshkina, Natasha; Fenouil, Romain; Gardner, Thomas J; Aguirre, Sebastian; Shah, Priya S; Zhao, Nan; Manganaro, Lara; Hultquist, Judd F; Noel, Justine; Sachs, David; Hamilton, Jennifer; Leon, Paul E; Chawdury, Amit; Tripathi, Shashank; Melegari, Camilla; Campisi, Laura; Hai, Rong; Metreveli, Giorgi; Gamarnik, Andrea V; García-Sastre, Adolfo; Greenbaum, Benjamin; Simon, Viviana; Fernandez-Sesma, Ana; Krogan, Nevan J; Mulder, Lubbertus C F; van Bakel, Harm; Tortorella, Domenico; Taunton, Jack; Palese, Peter; Marazzi, Ivan.

Immunity ; 44(1): 46-58, 2016 Jan 19.

Artigo em Inglês | MEDLINE | ID: mdl-26789921

4.

A low-background, fluorescent assay to evaluate inhibitors of diverse viral proteases.

Leonard, Rebecca A; Rao, Vishwas N; Bartlett, Alexandria; Froggatt, Heather M; Luftig, Micah A; Heaton, Brook E; Heaton, Nicholas S.

J Virol ; 97(8): e0059723, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37578235

5.

In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection.

Hamele, Cait E; Russell, Alistair B; Heaton, Nicholas S.

J Virol ; 96(14): e0050522, 2022 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-35867557

6.

A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.

Chaparian, Ryan R; Harding, Alfred T; Hamele, Cait E; Riebe, Kristina; Karlsson, Amelia; Sempowski, Gregory D; Heaton, Nicholas S; Heaton, Brook E.

J Virol ; 96(15): e0068922, 2022 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-35862698

7.

Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity.

Froggatt, Heather M; Burke, Kaitlyn N; Chaparian, Ryan R; Miranda, Hector A; Zhu, Xinyu; Chambers, Benjamin S; Heaton, Nicholas S.

PLoS Pathog ; 17(9): e1009951, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34570829

8.

TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.

Trimarco, Joseph D; Heaton, Brook E; Chaparian, Ryan R; Burke, Kaitlyn N; Binder, Raquel A; Gray, Gregory C; Smith, Clare M; Menachery, Vineet D; Heaton, Nicholas S.

PLoS Pathog ; 17(5): e1009599, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-34043740

9.

Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection.

Luo, Zhaochen; Girton, Alanson W; Heaton, Brook E; Heaton, Nicholas S.

J Virol ; 95(10)2021 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-33658342

10.

Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CL^pro Reporter Assay.

Froggatt, Heather M; Heaton, Brook E; Heaton, Nicholas S.

J Virol ; 94(22)2020 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-32843534

11.

Influenza viruses that require 10 genomic segments as antiviral therapeutics.

Harding, Alfred T; Haas, Griffin D; Chambers, Benjamin S; Heaton, Nicholas S.

PLoS Pathog ; 15(11): e1008098, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31730644

12.

Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.

Fiege, Jessica K; Stone, Ian A; Dumm, Rebekah E; Waring, Barbara M; Fife, Brian T; Agudo, Judith; Brown, Brian D; Heaton, Nicholas S; Langlois, Ryan A.

PLoS Pathog ; 15(9): e1008077, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31557273

13.

The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus.

Fulton, Benjamin O; Sun, Weina; Heaton, Nicholas S; Palese, Peter.

J Virol ; 92(16)2018 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-29899093

14.

Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity.

Hamilton, Jennifer R; Sachs, David; Lim, Jean K; Langlois, Ryan A; Palese, Peter; Heaton, Nicholas S.

Proc Natl Acad Sci U S A ; 113(14): 3861-6, 2016 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-27001854

15.

Viruses hijack a long non-coding RNA.

Heaton, Nicholas S; Cullen, Bryan R.

Nature ; 552(7684): 184-185, 2017 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-29239386

16.

Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies.

Fulton, Benjamin O; Palese, Peter; Heaton, Nicholas S.

J Virol ; 89(23): 12226-31, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26401044

17.

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.

Heaton, Nicholas S; Sachs, David; Chen, Chi-Jene; Hai, Rong; Palese, Peter.

Proc Natl Acad Sci U S A ; 110(50): 20248-53, 2013 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-24277853

18.

Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis.

Chou, Yi-ying; Heaton, Nicholas S; Gao, Qinshan; Palese, Peter; Singer, Robert H; Singer, Robert; Lionnet, Timothée.

PLoS Pathog ; 9(5): e1003358, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23671419

19.

In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies.

Heaton, Nicholas S; Leyva-Grado, Victor H; Tan, Gene S; Eggink, Dirk; Hai, Rong; Palese, Peter.

J Virol ; 87(15): 8272-81, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23698304

20.

Revisiting the concept of a cytopathic viral infection.

Heaton, Nicholas S.

PLoS Pathog ; 13(7): e1006409, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28727844

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