Detalhe da pesquisa
1.
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.
Bioorg Med Chem Lett
; 25(16): 3264-9, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26112443
2.
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.
Bioorg Med Chem Lett
; 25(16): 3275-80, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26105194
3.
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.
Bioorg Med Chem Lett
; 25(16): 3270-4, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26077492
4.
Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis.
Eur J Med Chem
; 265: 116038, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38157597
5.
Crystal structure of glucokinase regulatory protein.
Biochemistry
; 52(20): 3523-31, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23621087
6.
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
J Cell Biol
; 161(2): 281-94, 2003 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12707311
7.
Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.
J Mol Biol
; 334(5): 853-61, 2003 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14643652
8.
Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor ß receptor I (TGFßRI).
J Med Chem
; 53(20): 7287-95, 2010 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20919678
9.
Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
PLoS One
; 5(12): e14272, 2010 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21170314
10.
Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).
J Med Chem
; 52(14): 4466-80, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19522465
11.
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
Cancer Res
; 68(12): 4774-82, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559524
12.
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction.
Mol Cell Neurosci
; 24(2): 489-502, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14572469