Detalhe da pesquisa
1.
Nonhydrolyzable dphenylalanine-benzoxazole derivatives retain antitubercular activity.
Bioorg Med Chem Lett
; 80: 129116, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36572353
2.
Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition.
Bioorg Med Chem Lett
; 90: 129328, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37196868
3.
Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell.
Proc Natl Acad Sci U S A
; 116(42): 21160-21165, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31570573
4.
Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry.
Biochemistry
; 59(25): 2359-2370, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479091
5.
Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis.
Mol Microbiol
; 112(6): 1784-1797, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31532038
6.
Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late-onset disorder of mitochondrial DNA maintenance.
Clin Genet
; 97(2): 276-286, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31600844
7.
Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors.
Bioorg Med Chem Lett
; 30(24): 127543, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32931912
8.
Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.
Chem Res Toxicol
; 32(3): 456-466, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30746940
9.
Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.
Bioorg Med Chem Lett
; 29(2): 204-211, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528168
10.
Dynamic Characteristics of Guanosine-5'-monophosphate Reductase Complexes Revealed by High-Resolution 31P Field-Cycling NMR Relaxometry.
Biochemistry
; 57(22): 3146-3154, 2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29547266
11.
Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.
J Biol Chem
; 291(44): 22988-22998, 2016 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27613871
12.
Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
J Biol Chem
; 291(10): 5221-33, 2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26740621
13.
Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28739786
14.
Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.
Biochemistry
; 55(37): 5279-88, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541177
15.
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
J Biol Chem
; 290(9): 5893-911, 2015 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25572472
16.
Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.
J Biol Chem
; 289(42): 29208-18, 2014 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157102
17.
The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (ß/α)(8) barrel enzymes.
Crit Rev Biochem Mol Biol
; 47(3): 250-63, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22332716
18.
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.
Antimicrob Agents Chemother
; 58(3): 1603-14, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366728
19.
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (ß-α)8 barrel enzymes.
Nat Chem Biol
; 7(12): 950-8, 2011 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037469
20.
Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.
Bioorg Med Chem Lett
; 23(4): 1004-7, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23324406