Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Arginine reprograms metabolism in liver cancer via RBM39.

Mossmann, Dirk; Müller, Christoph; Park, Sujin; Ryback, Brendan; Colombi, Marco; Ritter, Nathalie; Weißenberger, Diana; Dazert, Eva; Coto-Llerena, Mairene; Nuciforo, Sandro; Blukacz, Lauriane; Ercan, Caner; Jimenez, Veronica; Piscuoglio, Salvatore; Bosch, Fatima; Terracciano, Luigi M; Sauer, Uwe; Heim, Markus H; Hall, Michael N.

Cell ; 186(23): 5068-5083.e23, 2023 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-37804830

2.

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.

Park, Sujin; Mossmann, Dirk; Chen, Qian; Wang, Xueya; Dazert, Eva; Colombi, Marco; Schmidt, Alexander; Ryback, Brendan; Ng, Charlotte K Y; Terracciano, Luigi M; Heim, Markus H; Hall, Michael N.

Mol Cell ; 82(22): 4246-4261.e11, 2022 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-36400009

3.

The IFN-λ Pony Express.

Wieland, Stefan F; Heim, Markus H.

Nat Immunol ; 20(5): 522-524, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30911106

4.

The protein histidine phosphatase LHPP is a tumour suppressor.

Hindupur, Sravanth K; Colombi, Marco; Fuhs, Stephen R; Matter, Matthias S; Guri, Yakir; Adam, Kevin; Cornu, Marion; Piscuoglio, Salvatore; Ng, Charlotte K Y; Betz, Charles; Liko, Dritan; Quagliata, Luca; Moes, Suzette; Jenoe, Paul; Terracciano, Luigi M; Heim, Markus H; Hunter, Tony; Hall, Michael N.

Nature ; 555(7698): 678-682, 2018 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-29562234

5.

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics.

Uzun, Sarp; Zinner, Carl P; Beenen, Amke C; Alborelli, Ilaria; Bartoszek, Ewelina M; Yeung, Jason; Calgua, Byron; Reinscheid, Matthias; Bronsert, Peter; Stalder, Anna K; Haslbauer, Jasmin D; Vosbeck, Juerg; Mazzucchelli, Luca; Hoffmann, Tobias; Terracciano, Luigi M; Hutter, Gregor; Manz, Michael; Panne, Isabelle; Boettler, Tobias; Hofmann, Maike; Bengsch, Bertram; Heim, Markus H; Bernsmeier, Christine; Jiang, Sizun; Tzankov, Alexandar; Terziroli Beretta-Piccoli, Benedetta; Matter, Matthias S.

J Hepatol ; 79(3): 666-676, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37290592

6.

Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model.

Suter, Polina; Dazert, Eva; Kuipers, Jack; Ng, Charlotte K Y; Boldanova, Tuyana; Hall, Michael N; Heim, Markus H; Beerenwinkel, Niko.

PLoS Comput Biol ; 18(9): e1009767, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36067230

7.

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells.

Lett, Martin J; Mehta, Hema; Keogh, Adrian; Jaeger, Tina; Jacquet, Maxime; Powell, Kate; Meier, Marie-Anne; Fofana, Isabel; Melhem, Hassan; Vosbeck, Jürg; Cathomas, Gieri; Heigl, Andres; Heim, Markus H; Burri, Emanuel; Mertz, Kirsten D; Niess, Jan Hendrik; Kollmar, Otto; Zech, Christoph J; Ivanek, Robert; Duthaler, Urs; Klenerman, Paul; Stroka, Deborah; Filipowicz Sinnreich, Magdalena.

Gut ; 71(12): 2526-2538, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-35058274

8.

Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load.

Meier, Marie-Anne; Calabrese, Diego; Suslov, Aleksei; Terracciano, Luigi M; Heim, Markus H; Wieland, Stefan.

J Hepatol ; 75(4): 840-847, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34004216

9.

Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through nested decision tree models.

Vosshenrich, Jan; Zech, Christoph J; Heye, Tobias; Boldanova, Tuyana; Fucile, Geoffrey; Wieland, Stefan; Heim, Markus H; Boll, Daniel T.

Eur Radiol ; 31(6): 4367-4376, 2021 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-33274405

10.

C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.

Kinast, Volker; Plociennikowska, Agnieszka; Bracht, Thilo; Todt, Daniel; Brown, Richard J P; Boldanova, Tujana; Zhang, Yudi; Brüggemann, Yannick; Friesland, Martina; Engelmann, Michael; Vieyres, Gabrielle; Broering, Ruth; Vondran, Florian W R; Heim, Markus H; Sitek, Barbara; Bartenschlager, Ralf; Pietschmann, Thomas; Steinmann, Eike.

J Hepatol ; 73(3): 549-558, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32294532

11.

Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients.

Flecken, Tobias; Meier, Marie-Anne; Skewes-Cox, Peter; Barkan, David T; Heim, Markus H; Wieland, Stefan F; Holdorf, Meghan M.

J Virol ; 93(9)2019 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-30787147

12.

Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver.

Suslov, Aleksei; Boldanova, Tujana; Wang, Xueya; Wieland, Stefan; Heim, Markus H.

Gastroenterology ; 154(6): 1778-1790, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29408639

13.

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.

Dazert, Eva; Colombi, Marco; Boldanova, Tujana; Moes, Suzette; Adametz, David; Quagliata, Luca; Roth, Volker; Terracciano, Luigi; Heim, Markus H; Jenoe, Paul; Hall, Michael N.

Proc Natl Acad Sci U S A ; 113(5): 1381-6, 2016 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-26787912

14.

miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.

Van Renne, Nicolaas; Roca Suarez, Armando Andres; Duong, Francois H T; Gondeau, Claire; Calabrese, Diego; Fontaine, Nelly; Ababsa, Amina; Bandiera, Simonetta; Croonenborghs, Tom; Pochet, Nathalie; De Blasi, Vito; Pessaux, Patrick; Piardi, Tullio; Sommacale, Daniele; Ono, Atsushi; Chayama, Kazuaki; Fujita, Masashi; Nakagawa, Hidewaki; Hoshida, Yujin; Zeisel, Mirjam B; Heim, Markus H; Baumert, Thomas F; Lupberger, Joachim.

Gut ; 67(5): 953-962, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-28159835

15.

SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo.

Blumer, Tanja; Coto-Llerena, Mairene; Duong, Francois H T; Heim, Markus H.

J Biol Chem ; 292(43): 17928-17938, 2017 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-28900038

16.

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis.

Bandiera, Simonetta; Pernot, Sophie; El Saghire, Hussein; Durand, Sarah C; Thumann, Christine; Crouchet, Emilie; Ye, Tao; Fofana, Isabel; Oudot, Marine A; Barths, Jochen; Schuster, Catherine; Pessaux, Patrick; Heim, Markus H; Baumert, Thomas F; Zeisel, Mirjam B.

J Virol ; 90(14): 6387-6400, 2016 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-27147737

17.

A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients.

Ulveling, Damien; Le Clerc, Sigrid; Cobat, Aurélie; Labib, Taoufik; Noirel, Josselin; Laville, Vincent; Coulonges, Cédric; Carpentier, Wassila; Nalpas, Bertrand; Heim, Markus H; Poynard, Thierry; Cerny, Andreas; Pol, Stanislas; Bochud, Pierre-Yves; Dabis, François; Theodorou, Ioannis; Lévy, Yves; Salmon, Dominique; Abel, Laurent; Dominguez, Stéphanie; Zagury, Jean-François.

Hepatology ; 64(5): 1462-1472, 2016 11.

Artigo em Inglês | MEDLINE | ID: mdl-27339598

18.

A systematic review and meta-analysis of HCV clearance.

Gauthiez, Emeline; Habfast-Robertson, Ines; Rüeger, Sina; Kutalik, Zoltan; Aubert, Vincent; Berg, Thomas; Cerny, Andreas; Gorgievski, Meri; George, Jacob; Heim, Markus H; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Negro, Francesco; Semela, David; Semmo, Nasser; Villard, Jean; Bibert, Stéphanie; Bochud, Pierre-Yves.

Liver Int ; 37(10): 1431-1445, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28261910

19.

Liver damage and senescence increases in patients developing hepatocellular carcinoma.

Rey, Silvia; Quintavalle, Cristina; Burmeister, Katharina; Calabrese, Diego; Schlageter, Manuel; Quagliata, Luca; Cathomas, Gieri; Diebold, Joachim; Molinolo, Alfredo; Heim, Markus H; Terracciano, Luigi M; Matter, Matthias S.

J Gastroenterol Hepatol ; 32(8): 1480-1486, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28052383

20.

MicroRNAs 103 and 107 regulate insulin sensitivity.

Trajkovski, Mirko; Hausser, Jean; Soutschek, Jürgen; Bhat, Bal; Akin, Akinc; Zavolan, Mihaela; Heim, Markus H; Stoffel, Markus.

Nature ; 474(7353): 649-53, 2011 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-21654750

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