RESUMO
The present report describes the development and application of a distributed interactive multi-person simulation in a computer-generated planetary environment as an experimental test bed for modeling the human performance effects of variations in the types of communication modes available, and in the types of stress and incentive conditions underlying the completion of mission goals. The results demonstrated a high degree of interchangeability between communication modes(audio, text) when one mode was not available. Additionally, the addition of time pressure stress to complete tasks resulted in a reduction in performance effectiveness, and these performance reductions were ameliorated via the introduction of positive incentives contingent upon improved performances. The results obtained confirmed that cooperative and productive psychosocial interactions can be maintained between individually isolated and dispersed members of simulated spaceflight crews communicating and problem-solving effectively over extended time intervals without the benefit of one another's physical presence.
Assuntos
Astronautas/psicologia , Comunicação , Simulação por Computador , Processos Grupais , Voo Espacial , Simulação de Ambiente Espacial/psicologia , Comportamento Cooperativo , Feminino , Humanos , Relações Interpessoais , Masculino , Isolamento Social , Estresse Psicológico , Interface Usuário-ComputadorRESUMO
Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Choice reaction times increased by 191 ms over baseline at the 0.68 mg/kg dose. Choice reaction times above the 95th percentile (i.e., the slowest reaction times) were the most slowed by nifedipine. Accuracy of color matching was decreased at 0.20 and 0.68 mg/kg by an average range of 2-4%. The yellow and white stimuli were the most difficult to discriminate correctly, and were also the most impaired by nifedipine. Nifedipine's behavioral effects were not modulated by blood pressure changes because daily changes in choice reaction time and systolic blood pressure were not correlated, and hypertensive status did not determine the behavioral effects. Potential sources of nifedipine's behavioral performance effects are discussed, with blood pressure changes excluded as a probable mechanism.
Assuntos
Comportamento Animal/efeitos dos fármacos , Hipertensão Renovascular/fisiopatologia , Nifedipino/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Comportamento de Escolha/efeitos dos fármacos , Percepção de Cores/efeitos dos fármacos , Discriminação Psicológica/efeitos dos fármacos , Masculino , Papio , Tempo de Reação/efeitos dos fármacosRESUMO
The adult male baboons were trained on a psychophysical procedure to discriminate five synthetic, steady-state vowel sounds (/a/, /ae/, /e/, /U/, and /c/) from one another. A pulsed train of one vowel comprised the reference stimulus during a session. Animals were trained to press a lever and release the lever only when this reference vowel sound changed to one of the comparison vowels. All animals learned the vowel discriminations rapidly and, once learned, performed the discriminations at the 95-100% correct level. The IM administration of diazepam (0.32, 1.0, 3.2, and 10.0 mg/kg) produced dose-dependent decrements in vowel discriminability. The diazepam-induced decrements in vowel discriminability were correlated with the degree of spectral frequency differences found among the different vowels, with lower vowel discriminability scores found for those vowels with smaller spectral differences from the reference vowel. In contrast, oral administration of delta-9-THC (0.32, 1.0, 3.2, and 5.6 mg/kg) produced no decrements in vowel discriminability.
Assuntos
Diazepam/farmacologia , Discriminação Psicológica/efeitos dos fármacos , Dronabinol/farmacologia , Vocalização Animal , Animais , Relação Dose-Resposta a Droga , Injeções Intramusculares , PapioRESUMO
Repeated acquisition behavioral performances of normotensive and renovascular hypertensive baboons were tested before, during, and following chronic oral dosing with the beta-adrenergic antagonists atenolol HCl (2.6 mg/kg/day PO), and d,l propranolol HCl (6.8 mg/kg twice daily PO) in separate studies. Each study administered active drug for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Animals pressed five keys in sequence for food reinforcement during daily experimental sessions which consisted of alternating acquisition (new sequence learning) and performance (previously learned) task components. Atenolol increased response latencies during acquisition in comparison to performance components, and during early portions of sessions. Propranolol also increased response latencies during acquisition components in early periods of sessions, but fewer dependent measures were affected, and the magnitude of increases in response latencies was smaller (12% +/- 5 SEM) as compared with atenolol (47% +/- 13). Test doses of phencyclidine HCl (PCP) increased latencies to the same degree as atenolol. PCP markedly reduced accuracy, while atenolol or propranolol did not. Blood pressures remained stable under atenolol, and decreased by approximately 10-15 mmHg under propranolol. No differences between renovascular hypertensive and normotensive baboons were found as a function of drug conditions. Drug effects were not dependent on plasma propranolol concentration.
Assuntos
Atenolol/farmacologia , Condicionamento Operante/efeitos dos fármacos , Propranolol/farmacologia , Animais , Atenolol/sangue , Pressão Sanguínea/efeitos dos fármacos , Hipertensão Renovascular/fisiopatologia , Hipertensão Renovascular/psicologia , Masculino , Papio , Propranolol/sangueRESUMO
Baboons were trained in both auditory and visual reaction time procedures to release a response lever in the presence of low-intensity stimuli. By varying the stimulus intensity from trial to trial, functions relating reaction time (elapsed time from stimulus onset to lever release) to stimulus intensity were established, and detection thresholds were measured. The effects of acute, IM injections of d-methamphetamine (0.001-1.0 mg/kg) were examined on these psychophysical performance baselines. Reaction times for acoustic stimuli generally were faster for higher drug doses, whereas reaction times for visual stimuli either lengthened or shortened, depending on both drug dose and individual differences among animals. Auditory thresholds were unaffected at all drug doses studied, whereas visual thresholds were generally elevated at doses of 0.1 mg/kg and above.
Assuntos
Dextroanfetamina/farmacologia , Tempo de Reação/efeitos dos fármacos , Estimulação Acústica , Animais , Limiar Auditivo/efeitos dos fármacos , Papio , Estimulação Luminosa , Limiar SensorialRESUMO
Adult male baboons were trained on a psychophysical procedure that measured detection thresholds and reaction times for pure tone and white light stimuli. Intramuscular injections of diazepam or triazolam were given 30 min before session onset; stimulus intensity was randomly varied from trial to trial, and four to five estimates of sensory thresholds and reaction times were obtained throughout each session. Diazepam produced dose-related elevations of both auditory and visual thresholds and reaction times. Effects of a single high dose of diazepam were apparent 4-5 days after administration. Triazolam was approximately 100 times more potent than diazepam in elevating reaction times and visual thresholds, but did not elevate auditory thresholds. There were no residual effects of triazolam on the day after dosing. These results suggest that diazepam and triazolam produce qualitatively similar effects on basic psychophysical function, but that they can be differentiated on the basis of sensory modality changes and post-drug recovery time.
Assuntos
Limiar Auditivo/efeitos dos fármacos , Diazepam/farmacologia , Tempo de Reação/efeitos dos fármacos , Triazolam/farmacologia , Visão Ocular/efeitos dos fármacos , Animais , Cães , Masculino , Papio , Limiar Sensorial/efeitos dos fármacos , Fatores de TempoRESUMO
The effects of cocaine on speech sound discriminations was examined to determine whether cocaine's previously demonstrated effect in reducing speech sound discriminability was dependent upon either the type of stimuli employed (simple tones versus complex speech) or the procedure (stimulus detection versus stimulus discrimination). Because of demonstrated similarities in the way that baboons and humans discriminate speech, and in the way the CNS is thought to encode and process speech sounds in these two species, baboons were trained to perform a choice procedure to identify the occurrence of different synthetic vowel sounds (see text). Animals held down a lever and released the lever only when one of four target vowels sounded, and not when a fifth, standard vowel sounded. Acute IM administration of cocaine (0.0032-1.0 mg/kg) produced dose-dependent decreases in vowel discriminability that were mostly due to elevations in false alarms (i.e., releases to the standard vowel) following cocaine. Cocaine also shortened reaction times to the stimuli in two of three baboons, but to a much lesser extent than observed previously. These results suggest that cocaine may interfere with the ability of the CNS to process the acoustic cues in speech sounds, and that the effects of cocaine on reaction times may depend upon the complexity of the reaction time procedure employed.
Assuntos
Percepção Auditiva/efeitos dos fármacos , Cocaína/farmacologia , Entorpecentes/farmacologia , Tempo de Reação/efeitos dos fármacos , Animais , Relação Dose-Resposta a Droga , Masculino , Papio , Fatores de TempoRESUMO
The effects of cocaine and quinpirole were studied in baboons to determine whether quinpirole, a relatively selective D2/D3 dopamine agonist, produced effects similar to those of cocaine on perceptual and motor processes. To measure perceptual and motor function, three baboons were trained to discriminate differences between a standard vowel and four other synthetic vowels: response accuracy as well as response latencies, or "reaction times", were measured following drug administrations. Cocaine reduced reaction times in two baboons, and did not affect reaction times in a third; on the other hand, quinpirole lengthened reaction times in a dose-dependent manner in all baboons. Cocaine and quinpirole also differed in the time course to produce the maximal reaction time effect following drug administration. Cocaine and quinpirole did not differ consistently in their perceptual effects, as indicated by similar changes in d', a signal-detection index of discriminability. These distinct profiles of effects for cocaine and quinpirole suggest differing neurochemical actions for these two drugs.
Assuntos
Cocaína/farmacologia , Agonistas de Dopamina/farmacologia , Inibidores da Captação de Dopamina/farmacologia , Percepção/efeitos dos fármacos , Desempenho Psicomotor/efeitos dos fármacos , Quimpirol/farmacologia , Animais , Percepção Auditiva/efeitos dos fármacos , Relação Dose-Resposta a Droga , Masculino , Papio , Tempo de Reação/efeitos dos fármacos , Comportamento Verbal/efeitos dos fármacosRESUMO
Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only when this standard vowel sound changed to one of the four remaining comparison vowels. A lever release within 1.5 s of this change in vowel sounds was defined as a correct detection of the change from the standard vowel to one of the comparison vowels, and was reinforced. All baboons readily learned the vowel discriminations and detected vowel changes at the 90-100% correct performance level. Acute IM administration of cocaine prior to test sessions (0.00032-3.2 mg/kg) produced dose-dependent decrements in vowel discriminability. At the same time, cocaine shortened lever release latencies (reaction times) to the vowel stimuli in two of three baboons. The cocaine-induced decrements in vowel discriminability were correlated with the degree to which frequency differences occurred among the different vowels in that lower vowel discriminability scores were found for those vowels with smaller spectral differences from the standard vowel. Further, false alarm rates were not systematically affected by cocaine, indicating that the cocaine-induced decrements in vowel discrimination accuracy occurred in the absence of systematic changes in the reliability of the baboons' discrimination performances.
Assuntos
Cocaína/farmacologia , Discriminação Psicológica/efeitos dos fármacos , Entorpecentes/farmacologia , Tempo de Reação/efeitos dos fármacos , Estimulação Acústica , Animais , Relação Dose-Resposta a Droga , Masculino , Papio , FalaRESUMO
Single-unit responses were recorded from the auditory cortex of rhesus monkeys that were performing an auditory selective attention task. Acoustic stimuli were presented randomly to either the left or right ear through headphones. In a given block of trials one ear was selected as the ear to be attended, and was indicated by lighting either a left or right response key. The animal's task was to press the lighted key whenever stimuli were presented to the attended ear, but to make no response to stimuli presented to the other ear. The attended ear was alternated on successive blocks of trials. Fourteen of 77 units showed significantly greater rates of evoked discharges for an attended stimulus than for an identical non-attended stimulus. The increase in stimulus-evoked activity was not accompanied by any increase in spontaneous activity or by any changes in the pattern of a unit's response. Changes in firing rate occurred at latencies as early as 20 msec.
Assuntos
Atenção/fisiologia , Córtex Auditivo/fisiologia , Percepção Auditiva/fisiologia , Dominância Cerebral/fisiologia , Estimulação Acústica/métodos , Animais , Sinais (Psicologia) , Aprendizagem por Discriminação/fisiologia , Potenciais Evocados , Haplorrinos , Macaca mulatta , Neurônios/fisiologiaRESUMO
Single-unit recordings were made from the auditory cortex of unanesthetized rhesus monkeys which were trained to perform a second localization task. Recordings were made from 196 units in 4 animals. Five sound sources were located at 0 degrees (midline) and on either side at azimuths of 37.5 degrees and 75 degrees. Almost most units responded to each of the 5 sources, 49% of the units had peak firing rates for the source on the contralateral side at 75% azimuth. Another 26% of the units had peak firing rates at the 37.5 degrees contralateral location, while only 11% had peak rates for the ipsilateral locations. In order to determine whether the behavior of actively locating a sound source affected units in auditory cortex, response rates compared under two behavioral conditions: one which required the detection of a sound regardless of location and another condition which required identification of a sound's location. of the 196 units, 16 had different response rates for the two conditions, with 15 of the 16 units having higher evoked rates in the localization task. For the 16 units, the difference in firing rate was typically observed for a single speaker location. No correlation could be determined between a unit's location within the subdivisions of auditory cortex and its spatial tuning response properties or its dependency upon behavioral condition.
Assuntos
Córtex Auditivo/fisiologia , Percepção Auditiva/fisiologia , Comportamento Animal/fisiologia , Localização de Som/fisiologia , Animais , Vias Auditivas/fisiologia , Condicionamento Operante/fisiologia , Aprendizagem por Discriminação/fisiologia , Potenciais Evocados Auditivos , Feminino , Macaca mulatta , Neurônios/fisiologiaRESUMO
Single-unit responses were recorded from the auditory cortex of rhesus monkeys performing a selective atteintion task which used combined light and sound stimuli. The animals were first trained to push a lever to the left for a noise burst and to the right for a tone burst, and then trained to push left for a left light and right for a right light. Subsequently, one of the four possible light and sound stimulus combinations (Noise + Left Light, Noise + Right Light, Tone + Left Light, Tone + Right Light) was randomly presented on each trial. In blocks of 100 trials only one part of the combined stimulus (either the light or the sound) determined the direction of lever push that would be reinforced. Responses of single units to identical sound stimuli were compared for blocks in which sound was the relevant cue and blocks in which light was the relevant cue. Typically, differences were in response strength without alteration of response pattern. Even the earliest response components (15-20 msec latency) could show changes. Two-thirds of the response comparisons showed differences in strength depending upon whether sound or light was the relevant cue, with about as many responses stronger for light relevant as for sound relevant. Independent of which modality was relevant, unit responses for trials in which both parts of the combined light and sound stimulus indicated the same direction of lever push were generally stronger than unit responses for trials in which the two parts of the combined stimulus signalled opposite directions of lever pushes.
Assuntos
Atenção/fisiologia , Córtex Auditivo/fisiologia , Potenciais Evocados , Animais , Córtex Auditivo/citologia , Percepção Auditiva/fisiologia , Discriminação Psicológica/fisiologia , Haplorrinos , Neurônios/fisiologia , Percepção Visual/fisiologiaRESUMO
Baboons with a history of chronic, daily ethanol ingestion were subsequently studied under conditions that assessed the effects of acute oral self-administration of ethanol on auditory and visual threshold functions and reaction times. During the post-chronic experiment reported herein, the animals consumed specific amounts of ethanol twice weekly (0.1, 0.32, 1.0 or 1.3 g/kg), following which they immediately performed psychophysical tests designed to assess ethanol's effects on sensory thresholds and reaction times. Clear, dose-related increases in reaction times were observed following ethanol doses greater than 0.32 g/kg. Trends within individual threshold functions were consistent with systematic changes in auditory and visual threshold sensitivities of 1-3 dB at the high ethanol doses. Reaction time increases ranged from 25 to 180 ms above baseline levels at the highest dose (a 15% average increase). These general findings however, were in contrast to data obtained in the same animals under conditions of daily, chronic ethanol administration which characteristically showed greater sensory/motor effects of up to twice the magnitude of those observed with single doses.
Assuntos
Intoxicação Alcoólica/fisiopatologia , Alcoolismo/fisiopatologia , Limiar Auditivo/fisiologia , Tempo de Reação/fisiologia , Percepção Visual/fisiologia , Consumo de Bebidas Alcoólicas/fisiopatologia , Animais , Relação Dose-Resposta a Droga , Masculino , Papio , Psicofísica , Limiar Sensorial/fisiologiaRESUMO
Baboons were trained to ingest ethanol at successively higher ethanol concentrations using oral self-administration techniques. Concurrently, animal psychophysical procedures were employed to determine auditory thresholds and reaction times daily. Maximal consumption of ethanol occurred at concentrations of 6-8% (w/v). During the initial period of ethanol self-administration, both auditory reaction times and auditory thresholds became elevated as animals consumed larger amounts of ethanol. For both the threshold and reaction time measures, the degree of elevation was correlated with the amount of ethanol consumed. These correlations decreased, however, with continued ethanol consumption. The elevations in sensory and motor function recovered to near-baseline levels when ethanol was no longer available.
Assuntos
Limiar Auditivo/efeitos dos fármacos , Etanol/administração & dosagem , Tempo de Reação/efeitos dos fármacos , Animais , Relação Dose-Resposta a Droga , Etanol/farmacologia , Masculino , Papio , AutoadministraçãoRESUMO
The effects of acute administration of the opioid compounds buprenorphine, morphine, and naloxone were studied on auditory and visual threshold functions and reaction time performances in baboons. Baboons were trained in a reaction time procedure to hold a lever depressed, and release the lever when a signal was presented. Auditory and visual signals were employed in separate sessions. Drug was administered 30min prior to testing. Dose-related increases in visual and auditory thresholds were observed following buprenorphine, with visual thresholds being somewhat more drug-sensitive. Buprenorphine also increased reaction times to both high-intensity and low-intensity stimuli. High doses of morphine increased reaction times to high-intensity auditory and low-intensity visual stimuli; thresholds for both modalities were unaffected by any dose of morphine. Naloxone produced no consistent effects on thresholds or reaction times. False alarm rates were not significantly changed by buprenorphine, morphine, or naloxone.
RESUMO
Baboon subjects were instrumented with indwelling arterial catheters for continuous measurement of blood pressure and heart rate before, during, and after exposure to industrial noise eight hours daily. Initial exposure to noise produced transient, acute elevations of systolic and diastolic blood pressures and heart rates at noise onset, which habituated over the course of noise exposure. Chronic exposure to noise lowered blood pressure and heart rate not only during noise, but particularly after daily noise offset. Blood pressures returned toward baseline after noise exposure was terminated. Plasma catecholamines were also decreased during noise exposure. A control animal which received only masking noise did not demonstrate decreases in cardiovascular parameters. The possibility of classically conditioned associations of noise onset with feeding was discussed.
Assuntos
Nível de Alerta , Ruído Ocupacional/efeitos adversos , Ruído/efeitos adversos , Animais , Nível de Alerta/fisiologia , Limiar Auditivo/fisiologia , Pressão Sanguínea , Condicionamento Operante/fisiologia , Epinefrina/sangue , Habituação Psicofisiológica/fisiologia , Frequência Cardíaca , Masculino , Norepinefrina/sangue , PapioRESUMO
Blackbirds and pigeons were trained to detect tones in quiet and in broadband noise by using positive-reinforcement techniques. In Experiment 1, thresholds in noise were obtained in blackbirds as a function of both tone frequency and noise intensity for a pulsed noise masker (noise gated on and off with tone). For blackbirds, critical ratios (the ratio of the power of the just-detectable tone in noise to the power of the noise masker) obtained in pulsed noise showed no consistent relation to tone frequency. For pigeons, on the other hand, critical ratios obtained in continuous noise increased by about 3 dB/octave across their range of hearing, being similar to known critical ratio functions for cats and humans. In Experiment 2, critical ratios in blackbirds obtained with both continuous noise and pulsed noise were compared. Blackbird critical ratios were more stable in continuous noise and averaged 4 dB lower than critical ratios in pulsed noise. The blackbird critical ratio function obtained with continuous noise was similar to the known critical ratio function of another avian species, the parakeet. Thus, small birds appear to have atypical critical ratio functions, compared with pigeons and other vertebrates.
Assuntos
Limiar Auditivo , Aves , Columbidae , Ruído , Percepção da Altura Sonora , Animais , Fadiga Auditiva , Feminino , Masculino , Mascaramento Perceptivo , Especificidade da EspécieRESUMO
Operant conditioning procedures were used to measure the effects of bilateral olivocochlear lesions on the cat's discrimination thresholds for changes in the second formant frequency (deltaF2) of the vowel /epsilon/. Three cats were tested with the formant discrimination task under quiet conditions and in the presence of continuous broadband noise at signal-to-noise ratios (S/Ns) of 23, 13, and 3 dB. In quiet, vowel levels of 50 and 70 dB produced average deltaF2s of 42 and 47 Hz, respectively, and these thresholds did not change significantly in low levels of background noise (S/Ns = 23 and 13 dB). Average deltaF2s increased to 94 and 97 Hz for vowel levels of 50 and 70 dB in the loudest level of background noise (S/N = 3 dB). Average deltaF2 thresholds in quiet and in lower noise levels were only slightly affected when the olivocochlear bundle was lesioned by making bilateral cuts into the floor of the IVth ventricle. In contrast, post-lesion deltaF2 thresholds in the highest noise level were significantly larger than pre-lesion values; the most severely affected subject showed post-lesion discrimination thresholds well over 200 Hz for both 50 and 70 dB vowels. These results suggest that olivocochlear feedback may enhance speech processing in high levels of ambient noise.
Assuntos
Cóclea/inervação , Cóclea/fisiologia , Núcleo Olivar/fisiologia , Percepção da Fala/fisiologia , Estimulação Acústica , Potenciais de Ação , Animais , Gatos , Cóclea/lesões , Denervação , Vias Eferentes/lesões , Vias Eferentes/fisiologia , Retroalimentação , Células Ciliadas Auditivas Externas/lesões , Células Ciliadas Auditivas Externas/fisiologia , Masculino , Ruído , Núcleo Olivar/anatomia & histologia , Núcleo Olivar/lesõesRESUMO
The effects of single oral doses of the calcium channel blocker nifedipine were assessed on performance of a simultaneous color match-to-sample task in three normotensive baboons. Both accuracy of color matching, and speed and latency of response were measured 30 min after administration of 0.10, 0.34, 0.57, and 1.7 mg/kg and vehicle, with each dose tested on three occasions in randomized order. Systolic and diastolic blood pressures also were measured after testing sessions. Maximal decreases in systolic blood pressures (mean of three subjects = -4.56 mmHg) were obtained after ingestion of the 0.57 mg/kg dose. Nifedipine produced dose-related changes in choice reaction times with a trend toward increased reaction times of approximately 5% obtained at 0.34 and 1.7 mg/kg. A reversal of effect was noted at 0.57 mg/kg such that smaller changes in reaction times were obtained, suggesting a lack of correlation between blood pressure and behavioral performance changes. These results indicate that nifedipine administered in single doses to patients with hypertensive crisis is unlikely to produce large impairments in these aspects of sensory and motor functioning.
Assuntos
Comportamento Animal/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Discriminação Psicológica/efeitos dos fármacos , Nifedipino/farmacologia , Animais , Relação Dose-Resposta a Droga , Masculino , Papio , Tempo de Reação/efeitos dos fármacosRESUMO
Sensory and behavioral performance of three normotensive and one renovascular hypertensive baboon was tested before, during and following chronic oral dosing with the angiotensin converting enzyme (ACE) inhibitor enalapril. Performance measurements during a five-color simultaneous matching to sample task were obtained during enalapril dosing of 0.18 and 0.61 mg/kg/day, and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14 baseline and recovery periods, respectively. BP from awake animals as well as serum ACE activity were measured. Systolic BPs decreased by a maximum of 6-8% (8 mmHg). ACE activity was decreased in a dose-dependent fashion by 54.01% and 81.63% for 0.18 mg/kg and 0.61 mg/kg doses, respectively. At 0.61 mg/kg, the duration of simple key-press motor behavior increased by 15% in the first week and then progressively returned to baseline levels. Systematic changes in choice reaction times or color discrimination accuracy were not observed. Although the renovascular hypertensive baboon displayed greater hypotension and ACE inhibition, behavioral effects were not significantly different from normotensive baboons. The present study extends to sensory functions the lack of adverse behavioral side-effects of enalapril.