Detalhe da pesquisa
1.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903390
2.
Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.
Anal Biochem
; 384(1): 56-67, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18762159
3.
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun
; 8: 15827, 2017 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28604669
4.
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain.
ACS Med Chem Lett
; 7(6): 552-7, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326325
5.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26090771
6.
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.
ACS Med Chem Lett
; 5(11): 1190-5, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25408830
7.
Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design.
Protein Sci
; 22(8): 1071-7, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776076