Detalhe da pesquisa
1.
Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability.
J Bacteriol
; 202(5)2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818925
2.
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.
Bioorg Med Chem
; 25(15): 4008-4030, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28601510
3.
N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.
Org Biomol Chem
; 13(15): 4449-58, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25766752
4.
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
Bioorg Med Chem
; 23(17): 5502-10, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275679
5.
N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
ChemMedChem
; 18(15): e202300211, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37264975
6.
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
Bioorg Med Chem
; 20(3): 1222-30, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22249123
7.
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Bioorg Med Chem
; 20(2): 1076-89, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22178188
8.
Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.
Eur J Med Chem
; 239: 114559, 2022 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35763869
9.
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
J Med Chem
; 65(5): 4030-4057, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35175749
10.
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
Bioorg Med Chem
; 19(15): 4445-53, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21745746
11.
Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro.
Sci Rep
; 11(1): 13317, 2021 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34172767
12.
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
Eur J Med Chem
; 219: 113416, 2021 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887682
13.
C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
Eur J Med Chem
; 225: 113798, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482272
14.
Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
J Med Chem
; 64(9): 5710-5729, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891818
15.
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorg Med Chem
; 17(17): 6218-32, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19666228
16.
Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.
FEBS J
; 286(23): 4721-4736, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31287615
17.
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
Eur J Med Chem
; 183: 111667, 2019 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31536893
18.
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
PLoS Negl Trop Dis
; 12(2): e0006301, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29481567
19.
Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem Biol
; 13(1): 82-90, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29161011
20.
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochimie
; 135: 6-14, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082125