Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The molecular basis for cellular function of intrinsically disordered protein regions.

Holehouse, Alex S; Kragelund, Birthe B.

Nat Rev Mol Cell Biol ; 25(3): 187-211, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-37957331

2.

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation.

Dorone, Yanniv; Boeynaems, Steven; Flores, Eduardo; Jin, Benjamin; Hateley, Shannon; Bossi, Flavia; Lazarus, Elena; Pennington, Janice G; Michiels, Emiel; De Decker, Mathias; Vints, Katlijn; Baatsen, Pieter; Bassel, George W; Otegui, Marisa S; Holehouse, Alex S; Exposito-Alonso, Moises; Sukenik, Shahar; Gitler, Aaron D; Rhee, Seung Y.

Cell ; 184(16): 4284-4298.e27, 2021 08 05.

Artigo em Inglês | MEDLINE | ID: mdl-34233164

3.

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.

Guillén-Boixet, Jordina; Kopach, Andrii; Holehouse, Alex S; Wittmann, Sina; Jahnel, Marcus; Schlüßler, Raimund; Kim, Kyoohyun; Trussina, Irmela R E A; Wang, Jie; Mateju, Daniel; Poser, Ina; Maharana, Shovamayee; Ruer-Gruß, Martine; Richter, Doris; Zhang, Xiaojie; Chang, Young-Tae; Guck, Jochen; Honigmann, Alf; Mahamid, Julia; Hyman, Anthony A; Pappu, Rohit V; Alberti, Simon; Franzmann, Titus M.

Cell ; 181(2): 346-361.e17, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32302572

4.

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins.

Wang, Jie; Choi, Jeong-Mo; Holehouse, Alex S; Lee, Hyun O; Zhang, Xiaojie; Jahnel, Marcus; Maharana, Shovamayee; Lemaitre, Régis; Pozniakovsky, Andrei; Drechsel, David; Poser, Ina; Pappu, Rohit V; Alberti, Simon; Hyman, Anthony A.

Cell ; 174(3): 688-699.e16, 2018 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-29961577

5.

FUS Zigzags Its Way to Cross Beta.

Holehouse, Alex S; Pappu, Rohit V.

Cell ; 171(3): 499-500, 2017 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-29053965

6.

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

Boeynaems, Steven; Dorone, Yanniv; Zhuang, Yanrong; Shabardina, Victoria; Huang, Guozhong; Marian, Anca; Kim, Garam; Sanyal, Anushka; Sen, Nesli-Ece; Griffith, Daniel; Docampo, Roberto; Lasker, Keren; Ruiz-Trillo, Iñaki; Auburger, Georg; Holehouse, Alex S; Kabashi, Edor; Lin, Yi; Gitler, Aaron D.

Mol Cell ; 83(12): 2020-2034.e6, 2023 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-37295429

7.

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.

Townley, Brittany A; Buerer, Luke; Tsao, Ning; Bacolla, Albino; Mansoori, Fadhel; Rusanov, Timur; Clark, Nathanial; Goodarzi, Negar; Schmidt, Nicolas; Srivatsan, Sridhar Nonavinkere; Sun, Hua; Sample, Reilly A; Brickner, Joshua R; McDonald, Drew; Tsai, Miaw-Sheue; Walter, Matthew J; Wozniak, David F; Holehouse, Alex S; Pena, Vladimir; Tainer, John A; Fairbrother, William G; Mosammaparast, Nima.

Mol Cell ; 83(13): 2258-2275.e11, 2023 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-37369199

8.

Step on the cGAS! Viral inhibition of cGAS phase separation with cytosolic DNA.

Minhas, Shubhanjali; Holehouse, Alex S.

Mol Cell ; 81(13): 2688-2689, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-34214443

9.

Dissecting the biophysics and biology of intrinsically disordered proteins.

Banerjee, Priya R; Holehouse, Alex S; Kriwacki, Richard; Robustelli, Paul; Jiang, Hao; Sobolevsky, Alexander I; Hurley, Jennifer M; Mendell, Joshua T.

Trends Biochem Sci ; 49(2): 101-104, 2024 02.

Artigo em Inglês | MEDLINE | ID: mdl-37949765

10.

Mapping from sequence to droplets.

Holehouse, Alex S.

Nat Rev Mol Cell Biol ; 22(3): 163, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33473198

11.

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.

Greig, Jamie A; Nguyen, Tu Anh; Lee, Michelle; Holehouse, Alex S; Posey, Ammon E; Pappu, Rohit V; Jedd, Gregory.

Mol Cell ; 77(6): 1237-1250.e4, 2020 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-32048997

12.

Intrinsically disordered regions are poised to act as sensors of cellular chemistry.

Moses, David; Ginell, Garrett M; Holehouse, Alex S; Sukenik, Shahar.

Trends Biochem Sci ; 48(12): 1019-1034, 2023 12.

Artigo em Inglês | MEDLINE | ID: mdl-37657994

13.

Direct prediction of intrinsically disordered protein conformational properties from sequence.

Lotthammer, Jeffrey M; Ginell, Garrett M; Griffith, Daniel; Emenecker, Ryan J; Holehouse, Alex S.

Nat Methods ; 21(3): 465-476, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38297184

14.

Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana.

Powers, Samantha K; Holehouse, Alex S; Korasick, David A; Schreiber, Katherine H; Clark, Natalie M; Jing, Hongwei; Emenecker, Ryan; Han, Soeun; Tycksen, Eric; Hwang, Ildoo; Sozzani, Rosangela; Jez, Joseph M; Pappu, Rohit V; Strader, Lucia C.

Mol Cell ; 76(1): 177-190.e5, 2019 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-31421981

15.

Hyperphosphorylation tunes TDP-43 solubility.

Ginell, Garrett M; Holehouse, Alex S.

EMBO J ; 41(8): e111062, 2022 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-35307855

16.

The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA.

Cubuk, Jasmine; Alston, Jhullian J; Incicco, J Jeremías; Holehouse, Alex S; Hall, Kathleen B; Stuchell-Brereton, Melissa D; Soranno, Andrea.

Nucleic Acids Res ; 52(5): 2609-2624, 2024 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-38153183

17.

SHEPHARD: a modular and extensible software architecture for analyzing and annotating large protein datasets.

Ginell, Garrett M; Flynn, Aidan J; Holehouse, Alex S.

Bioinformatics ; 39(8)2023 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-37540173

18.

Stress granules offer first aid for leaky organelles.

Plassmeyer, Stephen P; Holehouse, Alex S.

Nature ; 623(7989): 919-920, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37968460

19.

Transcription factor dimerization activates the p300 acetyltransferase.

Ortega, Esther; Rengachari, Srinivasan; Ibrahim, Ziad; Hoghoughi, Naghmeh; Gaucher, Jonathan; Holehouse, Alex S; Khochbin, Saadi; Panne, Daniel.

Nature ; 562(7728): 538-544, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30323286

20.

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.

Pak, Chi W; Kosno, Martyna; Holehouse, Alex S; Padrick, Shae B; Mittal, Anuradha; Ali, Rustam; Yunus, Ali A; Liu, David R; Pappu, Rohit V; Rosen, Michael K.

Mol Cell ; 63(1): 72-85, 2016 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-27392146

BVS Doenças Infecciosas e Parasitárias

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: