Detalhe da pesquisa
1.
Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.
J Biol Chem
; 292(43): 17598-17608, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28860191
2.
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.
J Pharmacol Exp Ther
; 361(1): 140-150, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28174211
3.
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
Blood
; 126(16): 1930-9, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26320100
4.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
5.
Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Proc Natl Acad Sci U S A
; 110(24): 9806-11, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23720316
6.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355874
7.
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.
J Neurosci
; 34(43): 14328-37, 2014 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25339746
8.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Proc Natl Acad Sci U S A
; 109(14): 5364-9, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434908
9.
Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.
J Org Chem
; 77(17): 7187-211, 2012 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22853001
10.
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury.
Sci Rep
; 11(1): 9018, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33907245
11.
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.
Sci Transl Med
; 12(544)2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32434848
12.
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.
Neuropsychopharmacology
; 44(6): 1152-1162, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30647450
13.
2-Hydroxypropyl-ß-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1864(10): 1545-1561, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31051283
14.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Sci Transl Med
; 10(431)2018 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29515000
15.
Functionally Biased D2R Antagonists: Targeting the ß-Arrestin Pathway to Improve Antipsychotic Treatment.
ACS Chem Biol
; 13(4): 1038-1047, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485852
16.
Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Future Med Chem
; 8(17): 2033-2046, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27739327
17.
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body ß-hydroxybutyrate.
Elife
; 52016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27253067
18.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection.
ACS Chem Biol
; 11(2): 363-74, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26640968
19.
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
ACS Chem Biol
; 11(7): 1952-63, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27128528
20.
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.
Chem Biol
; 22(4): 439-445, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25892200