RESUMO
As a global problem, fine particulate matter (PM2.5) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, the most important question is to clarify whether and how PM2.5 causally contributes to these mental disorders and which components are the most dangerous for crucial mitigation in a particular place. In the present study, we chronically subjected male mice to a real-world PM2.5 exposure system throughout the winter heating period in a coal combustion area and revealed that PM2.5 caused anxiety and depression-like behaviors in adults such as restricted activity, diminished exploratory interest, enhanced repetitive stereotypy, and elevated acquired immobility, through behavioral tests including open field, elevated plus maze, marble-burying, and forced swimming tests. Importantly, we found that dopamine signaling was perturbed using mRNA transcriptional profile and bioinformatics analysis, with Drd1 as a potential target. Subsequently, we developed the Drd1 expression-directed multifraction isolating and nontarget identifying framework and identified a total of 209 compounds in PM2.5 organic extracts capable of reducing Drd1 expression. Furthermore, by applying hierarchical characteristic fragment analysis and molecular docking and dynamics simulation, we clarified that phenyl-containing compounds competitively bound to DRD1 and interfered with dopamine signaling, thereby contributing to mental disorders. Taken together, this work provides experimental evidence for researchers and clinicians to identify hazardous factors in PM2.5 and prevent adverse health outcomes and for local governments and municipalities to control source emissions for diminishing specific disease burdens.
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Ansiedade , Depressão , Material Particulado , Receptores de Dopamina D1 , Animais , Material Particulado/toxicidade , Camundongos , Masculino , Ansiedade/metabolismo , Depressão/metabolismo , Receptores de Dopamina D1/metabolismo , Receptores de Dopamina D1/genética , Poluentes Atmosféricos/toxicidade , Comportamento Animal/efeitos dos fármacos , Simulação de Acoplamento MolecularRESUMO
BACKGROUND: Analyzing distance-dependent functional connectivity density (FCD) yields valuable insights into patterns of brain activity. Nevertheless, whether alterations of FCD in non-acute stroke patients are associated with the anatomical distance between brain regions remains unclear. This study aimed to explore the distance-related functional reorganization in non-acute stroke patients following left and right hemisphere subcortical lesions, and its relationship with clinical assessments. METHODS: In this study, we used resting-state fMRI to calculate distance-dependent (i.e., short- and long-range) FCD in 25 left subcortical stroke (LSS) patients, 22 right subcortical stroke (RSS) patients, and 39 well-matched healthy controls (HCs). Then, we compared FCD differences among the three groups and assessed the correlation between FCD alterations and paralyzed motor function using linear regression analysis. RESULTS: Our findings demonstrated that the left inferior frontal gyrus displayed distance-independent FCD changes, while the bilateral supplementary motor area, cerebellum, and left middle occipital gyrus exhibited distance-dependent FCD alterations in two patient subgroups compared with HCs. Furthermore, we observed a positive correlation between increased FCD in the bilateral supplementary motor area and the motor function of lower limbs, and a negative correlation between increased FCD in the left inferior frontal gyrus and the motor function of both upper and lower limbs across all stroke patients. These associations were validated by using a longitudinal dataset. CONCLUSIONS: The FCD in the cerebral and cerebellar cortices shows distance-related changes in non-acute stroke patients with motor dysfunction, which may serve as potential biomarkers for predicting motor outcomes after stroke. These findings enhance our comprehension of the neurobiological mechanisms driving non-acute stroke. TRIAL REGISTRATION: All data used in the present study were obtained from a research trial registered with the ClinicalTrials.gov database (NCT05648552, registered 05 December 2022, starting from 01 January 2022).
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Imageamento por Ressonância Magnética , Acidente Vascular Cerebral , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Encéfalo/fisiopatologia , Encéfalo/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Acidente Vascular Cerebral/fisiopatologia , Acidente Vascular Cerebral/diagnóstico por imagemRESUMO
Numerous studies indicate that fine particulate matters (PM2.5) and its organic components are urgent risk factors for cardiovascular diseases (CVDs). Combining toxicological experiments, effect-directed analyses, and nontarget identification, this study aims to explore whether PM2.5 exposure in coal-combustion areas induces myocardial fibrosis and how to identify the effective organic components and their toxic structures to support regional risk control. First, we constructed an animal model of real-world PM2.5 exposure during the heating season and found that the exposure impaired cardiac systolic function and caused myocardial fibrosis, with chemokine Ccl2-mediated inflammatory response being the key cause of collagen deposition. Then, using the molecular event as target coupled with two-stage chromatographic isolation and mass spectrometry analyses, we identified a total of 171 suspect organic compounds in the PM2.5 samples. Finally, using hierarchical characteristic fragment analysis, we predicted that 40 of them belonged to active compounds with 6 alert structures, including neopentane, butyldimethylamine, 4-ethylphenol, hexanal, decane, and dimethylaniline. These findings provide evidence for risk management and prevention of CVDs in polluted areas.
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Material Particulado , Animais , Camundongos , Masculino , Poluentes Atmosféricos , FibroseRESUMO
Emerging studies implicate fine particulate matter (PM2.5) and its organic components (OCs) as urgent hazard factors for lung cancer progression in nonsmokers. Establishing the adverse outcome pathway (AOP)-directed nontargeted identification method, this study aimed to explore whether PM2.5 exposure in coal-burning areas promoted lung tumor metastasis and how we identify its effective OCs to support traceability and control of regional PM2.5 pollution. First, we used a nude mouse model of lung cancer for PM2.5 exposure and found that the exposure significantly promoted the hematogenous metastases of A549-Luc cells in lung tissues and the adverse outcomes (AOs), with key events (KEs) including the changed expression of epithelial-mesenchymal transition (EMT) markers, such as suppression of E-cad and increased expression of Fib. Subsequently, using AOs and KEs as adverse outcome directors, we identified a total of 35 candidate chemicals based on the in vitro model and nontargeted analysis. Among them, tributyl phosphate (C12H27O4P), 2-bromotetradecane (C14H29Br), and methyl decanoate (C11H22O2) made greater contributions to the AOs. Finally, we clarified the interactions between these OCs and EMT-activating transcription factors (EMT-ATFs) as the molecular initiation event (MIE) to support the feasibility of the above identification strategy. The present study updates a new framework for identifying tumor metastasis-promoting OCs in PM2.5 and provides solid data for screening out chemicals that need priority control in polluted areas posing higher lung cancer risk.
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Rotas de Resultados Adversos , Poluentes Atmosféricos , Neoplasias Pulmonares , Animais , Camundongos , Material Particulado , Neoplasias Pulmonares/patologia , Pulmão , Transição Epitelial-MesenquimalRESUMO
In recent years, the prevalence and danger of organophosphorus flame retardants (OPFRs) have drawn attention from all around the world. This study examined twenty-five OPFRs observed in water and sediment samples from the Qiantang River in eastern China, as well as their occurrence, spatial distribution, possible origins, and ecological hazards. All the 25 OPFRs were detected in water and sediment samples. The levels of Σ25OPFRs in water and sediment were 35.5-192 ng/L and 8.84-48.5 ng/g dw, respectively. Chlorinated OPFRs were the main contributions in water, whereas alkyl-OPFRs were the most common congeners found in sediment. Spatial analysis revealed that sample locations in neighboring cities had somewhat higher water concentrations of OPFRs. Slowing down the river current and making the reservoir the main sink of OPFRs, the dam can prevent OPFRs from moving via the Qiantang River. Positive matrix factorization indicated that plasticizer in polyvinyl chloride, polyester resins, and polyurethane foam made the greatest contributions in water, whereas polyurethane foam and textile were the predominant source in sediment. Analysis of sediment-water exchange of OPFRs showed that twelve OPFRs in sediments can re-enter into the water body. The risk quotients showed the ecological risk was low to medium, but trixylyl phosphate exposures posed high ecological risk to aquatic organisms.
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Monitoramento Ambiental , Retardadores de Chama , Sedimentos Geológicos , Compostos Organofosforados , Rios , Poluentes Químicos da Água , Retardadores de Chama/análise , China , Rios/química , Medição de Risco , Poluentes Químicos da Água/análise , Sedimentos Geológicos/química , Compostos Organofosforados/análiseRESUMO
BACKGROUND: It is unclear which cortical regions are specific to or commonly associated with the impairments of the upper/lower limbs and the activities of daily life (ADL) in stroke patients. PURPOSE: To investigate the relationships between MRI-assessed surface-based morphometry (SBM) features and motor function as well as ADL in participants with chronic stroke. STUDY TYPE: Prospective. SUBJECTS: Thirty-five participants with subcortical stroke more than 3 months from the first-onset (age: 56.44 ± 9.56 years; 32 male). FIELD STRENGTH/SEQUENCE: T1 -weighted images, 3.0 T, three-dimensional fast field-echo sequence. ASSESSMENT: FreeSurfer (6.0) was used to parcellate each hemisphere into 34 regions based on the Desikan-Killiany atlas and to extract the surface area, volume, thickness, and curvature. The motor function and ADL were assessed by the Fugl-Meyer Assessment for the Upper/Lower Extremity (FMA-UE/FMA-LE) and the Chinese version of the Modified Barthel Index (MBI-C), respectively. STATISTICAL TESTS: A linear mixed-effect model was applied to evaluate the relationship between the morphological features and the FMA-UE, FMA-LE, and MBI-C. A false discovery rate corrected P value < 0.05 was considered statistically significant. RESULTS: Correlations between the size of stroke lesion and MRI measurements did not pass the FDR correction (adjusted P > 0.05). SBM features in motor-related and high-order cognitive cortical regions showed significant correlations with FMA-UE and FMA-LE, respectively. Moreover, the thickness in the prefrontal cortex significantly positively correlated, while the surface area in the right supramarginal gyrus significantly negatively correlated, with both FMA-UE, FMA-LE, and MBI-C. The thickness in the left frontal lobe significantly positively correlated with both FMA-UE and MBI-C. DATA CONCLUSION: This study's findings suggest that different hemiparetic motor-related outcomes in participants with subcortical stroke which suffered a corticospinal tract-related injury show specific, but also share common, associations with several cortical regions. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
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Acidente Vascular Cerebral , Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Estudos Prospectivos , Extremidade Superior , Imageamento por Ressonância Magnética , Lobo FrontalRESUMO
Atmospheric monitoring data of polycyclic aromatic hydrocarbons (PAHs) over a three-year period were collected from an urban site in Dalian, northeast China. The status of PAHs in the atmosphere in Dalian were evaluated by assessing concentration levels, congener profiles, seasonal trends, primary source, inhalation exposure and the risk of developing lung cancer risk. Average concentrations were recorded for 53 PAHs (95 ± 40 ng/m3), 16 EPA priority PAHs (68 ± 33 ng/m3), 26 alkylated PAHs (17 ± 7.6 ng/m3) and 4 high-molecular-weight (302 Da) PAHs (1.3 ± 1.3 ng/m3). Atmospheric PAH concentrations in winter were almost twice as high as those recorded in the summer, possibly due to enhanced local emissions and long-range transport of atmospheric PAHs during the winter. PAH congeners were dominated by phenatherene, fluoranthene, pyrene and fluorene, accounting for 46.0% of total ∑53PAH concentrations. Ship/vehicle emission and mixed combustion were identified as the main sources of PAHs using diagnostic PAH concentration ratios and principal component analysis-multiple linear regression. Benzo(a)pyrene toxicity equivalent concentration had an average content of 32 ± 37 ng/m-3 over the sampling period, with dibenzo(a,h)anthracene (50.7%) and dibenzo(a,l)pyrene (26.4%) being the largest contributors. The risk of developing lung cancer due to inhalation exposure to outdoor PAHs was calculated at 12.0 using the overall population attributable fraction (PAF). Our results estimate that, due to PAH exposure in Dalian, the average excess lung cancer risk during a person's lifetime is 35.7 cancer cases per one million inhabitants.
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Poluentes Atmosféricos/análise , Exposição por Inalação/análise , Neoplasias Pulmonares/epidemiologia , Hidrocarbonetos Policíclicos Aromáticos/análise , Estações do Ano , Emissões de Veículos/análise , Atmosfera/química , China , Cidades , Humanos , RiscoRESUMO
A total of 23 polybrominated diphenyl ether (PBDE) congeners were measured in soil samples collected in areas with no known point source [urban/rural/background (U/R/B) sites] and in areas with known point source [brominated flame retardant (BFR)-related industrial sites (F sites) and e-waste recycling sites (E sites)] across five Asian countries. The highest PBDE concentrations were found in BFR-related industrial and e-waste recycling sites. The concentrations of PBDEs in U/R/B sites decreased in the following order: urban > rural > background sites. Total PBDE concentrations were dominated by BDE-209, while BDE-17, -85, -138, -191, -204, and -205 were the least abundant compounds. In both urban sites and rural sites, the mean concentrations of total PBDEs (∑23BDEs) in soils decreased in the following order: Japan > China > South Korea > India > Vietnam. The concentrations of PBDEs in soils were comparable with those reported in other studies. Among the three commercial PBDE mixtures, relatively large contributions of commercial penta-BDE were observed in Vietnam, whereas deca-BDE was the dominant form in mixtures contributing from 55.8 ± 2.5 to 100.0 ± 1.2% of the total PBDEs in soils collected from other four countries. Regression analysis suggested that local population density (PD) is a good indicator of PBDEs in soils of each country. Significant and positive correlation between soil organic content and PBDE level was observed in Chinese soil for most nondeca-BDE homologues with their usage stopped 10 years ago, indicating its important role in controlling the revolatilization of PBDEs from soil and changing the spatial trend of PBDE in soil from the primary distribution pattern to the secondary distribution pattern, especially when primary emission is ceased.
Assuntos
Éteres Difenil Halogenados , Solo , China , Monitoramento Ambiental , Retardadores de Chama , Reciclagem , Poluentes do SoloRESUMO
A large-scale monitoring program, the Asia Soil and Air Monitoring Program (Asia-SAMP), was conducted in five Asian countries, including China, Japan, South Korea, Vietnam, and India. Air samples were collected using passive air samplers with polyurethane foam disks over four consecutive 3-month periods from September 2012 to August 2013 to measure the seasonal concentrations of 47 polycyclic aromatic hydrocarbons (PAHs), including 21 parent and 26 alkylated PAHs, at 176 sites (11 background, 83 rural, and 82 urban). The annual concentrations of total 47 PAHs (∑47PAHs) at all sites ranged from 6.29 to 688 ng/m(3) with median of 82.2 ng/m(3). Air concentrations of PAHs in China, Vietnam, and India were greater than those in Japan and South Korea. As expected, the air concentrations (ng/m(3)) were highest at urban sites (143 ± 117) followed by rural (126 ± 147) and background sites (22.4 ± 11.4). Significant positive correlations were found between PAH concentrations and atmosphere aerosol optical depth. The average benzo(a)pyrene equivalent concentration (BaPeq) was 5.61 ng/m(3). It was estimated that the annual BaPeq concentrations at 78.8% of the sampling sites exceeded the WHO guideline level. The mean population attributable fraction (PAF) for lung cancer due to inhalation exposure to outdoor PAHs was on the order 8.8 (0.056-52) for China, 0.38 (0.007-3.2) for Japan, 0.85 (0.042-4.5) for South Korea, 7.5 (0.26-27) for Vietnam, and 3.2 (0.047-20) for India. We estimated a number of lifetime excess lung cancer cases caused by exposure to PAHs, which the concentrations ranging from 27.8 to 2200, 1.36 to 108, 2.45 to 194, 21.8 to 1730, and 9.10 to 720 per million people for China, Japan, South Korea, Vietnam, and India, respectively. Overall, the lung cancer risk in China and Vietnam were higher than that in Japan, South Korea, and India.
Assuntos
Exposição por Inalação , Hidrocarbonetos Policíclicos Aromáticos , Ásia , Humanos , Neoplasias Pulmonares/epidemiologia , RiscoRESUMO
A total of 46 polycyclic aromatic hydrocarbons (PAHs, 21 parent and 25 alkylated) were determined in seawater, surface sediment and oyster from coastal area of Dalian, North China. The concentration of Σ46PAHs in seawater, sediment, and oyster were 136-621 ng/L, 172-4700 ng/g dry weight (dw) and 60.0-129 ng/g wet weight (ww) in winter, and 65.0-1130 ng/L, 71.1-1090 ng/g dw and 72.8-216 ng/g ww in summer, respectively. High PAH levels were found in industrial area both in winter and summer. Selected PAH levels in sediments were compared with Sediments Quality Guidelines (ERM-ERL, TEL-PEL indexes) for evaluation probable toxic effects on marine organism and the results indicate that surface sediment from all sampling sites have a low to medium ecotoxicological risk. Daily intake of PAHs via oyster as seafood by humans were estimated and the results indicated that oyster intake would not pose a health risk to humans even 30 days after a oil spill accident near by. Water-sediment exchange analysis showed that, both in winter and summer, the fluxes for most high molecular weight PAHs were from seawater to sediment, while for low molecular weight PAHs, an equilibrium was reached between seawater and sediment.
Assuntos
Ostreidae , Hidrocarbonetos Policíclicos Aromáticos/análise , Poluentes Químicos da Água/análise , Adulto , Animais , China , Monitoramento Ambiental , Contaminação de Alimentos/análise , Sedimentos Geológicos/análise , Humanos , Medição de Risco , Alimentos Marinhos/análise , Estações do Ano , Água do Mar/análiseRESUMO
Methyl siloxanes, which belong to organic silicon compounds and have linear and cyclic structures, are of particular concern because of their potential characteristic of persistent, bioaccumulated, toxic, and ecological harm. This study investigated the trophic transfer of four cyclic methyl siloxanes (octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), dodecamethylcyclohexasiloxane (D6), and tetradecamethylcycloheptasiloxane (D7)) in a marine food web from coastal area of Northern China. Trophic magnification of D4, D5, D6, and D7 were assessed as the slope of lipid equivalent concentrations regressed against trophic levels of marine food web configurations. A significant positive correlation (R = 0.44, p < 0.0001) was found between lipid normalized D5 concentrations and trophic levels in organisms, showing the trophic magnification potential of this chemical in the marine food web. The trophic magnification factor (TMF) of D5 was estimated to be 1.77 (95% confidence interval (CI): 1.41-2.24, 99.8% probability of the observing TMF > 1). Such a significant link, however, was not found for D4 (R = 0.14 and p = 0.16), D6 (R = 0.01 and p = 0.92), and D7 (R = -0.15 and p = 0.12); and the estimated values of TMFs (95% CI, probability of the observing TMF > 1) were 1.16 (0.94-1.44, 94.7%), 1.01 (0.84-1.22, 66.9%) and 0.85 (0.69-1.04, 48.6%) for D4, D6, and D7, respectively. The TMF value for the legacy contaminant BDE-99 was also estimated as a benchmark, and a significant positive correlation (R = 0.65, p < 0.0001) was found between lipid normalized concentrations and trophic levels in organisms. The TMF value of BDE-99 was 3.27 (95% CI: 2.49-4.30, 99.7% probability of the observing TMF > 1), showing the strong magnification in marine food webs. To the best of our knowledge, this is the first report on the trophic magnification of methyl siloxanes in China, which provided important information for trophic transformation of these compounds in marine food webs.
Assuntos
Cadeia Alimentar , Biologia Marinha/métodos , Siloxanas/química , China , Monitoramento Ambiental , Poluentes Químicos da Água/análiseRESUMO
Transcranial electrical stimulation (TES) is a promising non-invasive neuromodulation technique. How to increase the current intensity entering the skull and reduce scalp shunting has become a key factor significantly influencing regulatory efficacy. In this study, we introduce a novel approach for optimizing TES by adjusting local scalp temperature to modulate scalp conductivity. We have developed simulation models for TES-induced electric fields and for temperature-induced alterations in scalp conductivity. Two common types of stimulation montage (M1-SO and 4 × 1 montage) were adopted for the evaluation of effectiveness. We observed that the modulation of scalp temperature has a significant impact on the distribution of the electric field within the brain during TES. As local scalp temperature decreases, there is an increase in the maximum electric field intensity within the target area, with the maximum change reaching 18.3%, when compared to the electric field distribution observed under normal scalp temperature conditions. Our study provide insights into the practical implementation challenges and future directions for this innovative methodology.
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Estimulação Transcraniana por Corrente Contínua , Estimulação Transcraniana por Corrente Contínua/métodos , Couro Cabeludo , Temperatura , Encéfalo/fisiologia , Condutividade Elétrica , Estimulação ElétricaRESUMO
Ingestion of perfluoroalkyl acids (PFAAs) via contaminated food contact materials (FCMs) is an important human exposure source. This study adopts a toxicity equivalent approach to evaluate the collective health risk of multiple PFAAs in FCMs. A comprehensive extraction and analysis of 21 PFAAs in FCMs was performed. Among the analyzed substances, 15 PFAAs were detected. Migration experiment using three food simulants revealed the migration range of seven PFAAs from FCMs into the simulant to be 0.47-46.7 ng/cm2. The hazard quotient results suggest minimal health risk, except for 9% of packaged samples where perfluorooctanoic acid (PFOA) poses a higher risk. Utilizing PFOA toxic equivalent concentrations, comprehensive risk calculations showed â¼77% of samples potentially posing elevated health risks due to PFAA exposure. This emphasizes the substantial contribution of PFAAs beyond PFOA and underscores the importance of considering them in related assessments. The aggregated risk assessment reflects actual exposure circumstances more accurately.
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Polycyclic aromatic hydrocarbons (PAHs) were measured in concurrently sampled surface seawater and sediment collected at 20 sites around Dalian, China 50 days after an oil spill accident. The concentrations of total PAHs ranged from 15 to 160 ng L(-1) in seawater, and from 64 to 2100 ng g(-1) dry weight in surface sediment. The spatial trends of PAHs in seawater, but not in sediment, showed a significant negative correlation with the distance from the oil spill site, indicating a strong source of PAHs from oil spill place to the surrounding seawater. The similar profiles for PAH composition in both crude oil and seawater could indicate that oil spill caused PAHs concentration in seawater, but not in sediment. Analysis of water-sediment exchange of PAHs showed that the direction of the net flux of PAHs was from sediment to seawater for most priority PAHs, and from water to sediment for a few HWM-PAHs.
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Monitoramento Ambiental , Sedimentos Geológicos/química , Poluição por Petróleo , Hidrocarbonetos Policíclicos Aromáticos/análise , Água do Mar/química , China , Petróleo/análiseRESUMO
Twenty-eight surface sediment samples and one sediment core were analyzed for 21 organochlorine pesticides (OCPs), in order to provide extensive information of distribution, sources, pollution history and ecological risk of these OCP compounds in Daling River area, China. The results showed that hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs) were the most frequently detected contaminants in the surface sediment samples with concentrations (in ngg(-1) dry weight (dw)) from 1.1 to 30 and from 2.2 to 45, respectively. Analysis of variance showed significant (P<0.05) differences between HCHs and DDTs residues in surface sediment sampled from the various locations. Residues of HCHs and DDTs in sediment core (in ngg(-1)dw) ranged from 2.1 to 18 and 9.1 to 53, respectively. The temporal trends of HCHs and DDTs concentrations in the sediment core were affected by application history, emission and soil residues. Compositional analysis of HCHs and DDTs indicated that new sources were lindane and dicofol mainly due to agricultural activities. Additionally, based on the available sediment quality guidelines, slight potential health risks of DDTs may exist to benthic organisms in Daling River and Bohai Sea.
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Sedimentos Geológicos/química , Hidrocarbonetos Clorados/análise , Praguicidas/análise , Poluentes Químicos da Água/análise , Poluição Química da Água/estatística & dados numéricos , China , Ecologia , Monitoramento Ambiental , Hexaclorocicloexano/análise , Oceanos e Mares , Rios/química , SoloRESUMO
Studies have demonstrated that many regions in the human brain include multidirectional fiber tracts, in which the diffusion of water molecules within image voxels does not follow a Gaussian distribution. Therefore, the conventional diffusion tensor imaging (DTI) that hypothesizes a single fiber orientation within a voxel is intrinsically incapable of revealing the complex microstructures of brain tissues. Diffusion spectrum imaging (DSI) employs a pulse sequence with different b-values along multiple gradient directions to sample the diffusion information of water molecules in the entire q-space and then quantitatively estimates the diffusion profile using a probability density function with a high angular resolution. Studies have suggested that DSI can reliably observe the multidirectional fibers within each voxel and allow fiber tracking along different directions, which can improve fiber reconstruction reflecting the true but complicated brain structures that were not observed in the previous DTI studies. Moreover, with increasing angular resolution, DSI is able to reveal new neuroimaging biomarkers used for disease diagnosis and the prediction of disorder progression. However, so far, this method has not been used widely in clinical studies, due to its overly long scanning time and difficult post-processing. Within this context, the current paper aims to conduct a comprehensive review of DSI research, including the fundamental principles, methodology, and application progress of DSI tractography. By summarizing the DSI studies in recent years, we propose potential solutions towards the existing problem in the methodology and applications of DSI technology as follows: (1) using compressed sensing to undersample data and to reconstruct the diffusion signal may be an efficient and promising method for reducing scanning time; (2) the probability density function includes more information than the orientation distribution function, and it should be extended in application studies; and (3) large-sample study is encouraged to confirm the reliability and reproducibility of findings in clinical diseases. These findings may help deepen the understanding of the DSI method and promote its development in clinical applications.
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This study provides a comprehensive compilation of published toxicological and environmental data further used to assess the ecological risks of six antifouling biocides, including tributyltin (TBT), Irgarol 1051, Diuron, Chlorothalonil, 4,5-Dichloro-N-octyl-3(2H)-isothiazolone (DCOIT), and Dichlofluanid. The standard maximum concentration and standard continuous concentration of antifouling biocides were derived by the species susceptibility distribution method. Following that, the ecological risk assessment of antifouling biocides in the aquatic environment was conducted using the hazard quotient, margin of safety, joint probability curve, and Monte Carlo random sampling method. The following is a concise list of the antifouling biocide dangers associated with acute and chronic risks: Irgarol 1051 > TBT > Diuron > DCOIT > Chlorothalonil > Dichlofluanid. It is strongly advised that systematic and ongoing monitoring of these biocides in coastal areas take place, as well as the creation of acceptable and efficient environmental protection measures, to safeguard the coastal environment's services and functions.
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Incrustação Biológica , Desinfetantes , Poluentes Químicos da Água , Diurona/toxicidade , Diurona/análise , Qualidade da Água , Desinfetantes/análise , Incrustação Biológica/prevenção & controle , Triazinas/toxicidade , Poluentes Químicos da Água/análise , Monitoramento AmbientalRESUMO
Antifouling biocides may cause adverse effects on non-target species. This study aims to determine the distribution, sources, and ecological risks of antifouling biocides in the surface waters of the Qiantang River and its estuary in eastern China. The concentrations of total antifouling biocides were ranged from 12.9 to 215 ng/L for all water samples. Atrazine, diuron and tributyltin were the major compounds in the water bodies of the study area. The acute and chronic toxicity criteria for tributyltin, diuron and atrazine were derived for freshwater and saltwater, respectively, based on the species sensitivity distribution approach. The freshwater and saltwater criteria were slightly different, and the toxicity to aquatic organisms could be summarized as tributyltin > diuron > atrazine. The graded ecological risk rating showed that the long-term risk of TBT was significant in coastal waters. The pollution of TBT in the Qiantang River deserves further attention.
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Atrazina , Incrustação Biológica , Rios , Estuários , Incrustação Biológica/prevenção & controle , Diurona , Qualidade da Água , China , Medição de RiscoRESUMO
Dechloranes (Decs), including Dechlorane Plus (DP) and Dechlorane (Dec) 602, 603, 604, are used as flame retardants. Fifty four samples were collected in a river in northeastern China and analyzed for Decs by gas chromatography/mass spectrometry. The average concentrations of total DP (syn- and anti-) in water, sediment, air, reed (Phragmites australis), and fish (E. elongatus) were 0.30±0.24 (mean±SD) ng L(-1), 1.3±0.69 ng g(-1) dry weight (dw), 0.25±0.18 ng m(-3), 0.63±0.18 ng g(-1) wet weight (ww), and 29±20 ng g(-1) lipid weight (lw), respectively. While Dec 602 and Dec 603 were detected in most of sediment and fish samples, no Dec 604 was found in any of the investigated environmental matrices. The mean ratio of syn-DP to total DP (fsyn) in water, sediment, reed, and fish were 0.28, 0.25, 0.27 and 0.47, suggesting depletion in abiota and enrichment in biota for syn-DP. It was found that biota-sediment accumulation factor (BSAF) was 4.7 for Dec 602, 0.88 for syn-DP, and 0.33 for anti-DP.
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Monitoramento Ambiental , Peixes/metabolismo , Hidrocarbonetos Clorados/análise , Rios/química , Poluentes Químicos da Água/análise , Ar/análise , Animais , China , Retardadores de Chama/análise , Cromatografia Gasosa-Espectrometria de Massas , Sedimentos Geológicos/química , Compostos Policíclicos/análiseRESUMO
AIM: The inferior parietal lobule (IPL) plays important roles in reaching and grasping during hand movements, but how reorganizations of IPL subsystems underlie the paretic hand remains unclear. We aimed to explore whether specific IPL subsystems were disrupted and associated with hand performance after chronic stroke. METHODS: In this cross-sectional study, we recruited 65 patients who had chronic subcortical strokes and 40 healthy controls from China. Each participant underwent the Fugl-Meyer Assessment of Hand and Wrist and resting-state fMRI at baseline. We mainly explored the group differences in resting-state effective connectivity (EC) patterns for six IPL subregions in each hemisphere, and we correlated these EC patterns with paretic hand performance across the whole stroke group and stroke subgroups. Moreover, we used receiver operating characteristic curve analysis to distinguish the stroke subgroups with partially (PPH) and completely (CPH) paretic hands. RESULTS: Stroke patients exhibited abnormal EC patterns with ipsilesional PFt and bilateral PGa, and five sensorimotor-parietal/two parietal-temporal subsystems were positively or negatively correlated with hand performance. Compared with CPH patients, PPH patients exhibited abnormal EC patterns with the contralesional PFop. The PPH patients had one motor-parietal subsystem, while the CPH patients had one sensorimotor-parietal and three parietal-occipital subsystems that were associated with hand performance. Notably, the EC strength from the contralesional PFop to the ipsilesional superior frontal gyrus could distinguish patients with PPH from patients with CPH. CONCLUSIONS: The IPL subsystems manifest specific functional reorganization and are associated with hand dysfunction following chronic stroke.