Detalhe da pesquisa
1.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
2.
Challenges in profiling and lead optimization of drug discovery for methyltransferases.
Drug Discov Today Technol
; 18: 62-8, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26723894
3.
Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
J Med Chem
; 63(17): 10061-10085, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787083
4.
Chemical microarray: a new tool for drug screening and discovery.
Drug Discov Today
; 11(13-14): 661-8, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16793536
5.
Microarrays for the functional analysis of the chemical-kinase interactome.
J Biomol Screen
; 11(1): 48-56, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16314406
6.
Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases.
Cell Rep
; 14(4): 772-781, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26776524
7.
Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling.
Assay Drug Dev Technol
; 3(2): 177-87, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15871692
8.
Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.
Assay Drug Dev Technol
; 13(4): 221-34, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26065558
9.
Assay development for histone methyltransferases.
Assay Drug Dev Technol
; 11(4): 227-36, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557020
10.
Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays.
Methods Mol Biol
; 572: 161-76, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-20694691
11.
Chemical microarrays: a new tool for discovery enzyme inhibitors.
Methods Mol Biol
; 572: 149-60, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-20694690
12.
Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology.
Chem Biol Drug Des
; 67(1): 87-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492155
13.
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site.
Biochemistry
; 41(20): 6398-407, 2002 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12009902
14.
Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors.
Bioorg Med Chem Lett
; 14(6): 1483-6, 2004 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006386