RESUMO
Mycobacterium abscessus is a rapidly growing mycobacterium which is reportedly increasing in prevalence. Infection of the skin and soft tissue with M. abscessus is rare but typically associated with trauma. We present two cases of M. abscessus infection linked by penetration through wetsuits.
Assuntos
Infecções por Mycobacterium não Tuberculosas/microbiologia , Mycobacterium abscessus , Dermatopatias Bacterianas/microbiologia , Ferimentos Penetrantes/complicações , Adulto , Feminino , Humanos , Injeções Intramusculares/efeitos adversos , Masculino , Pessoa de Meia-Idade , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Roupa de Proteção , Dermatopatias Bacterianas/tratamento farmacológico , Úlcera Cutânea/microbiologia , NataçãoRESUMO
We describe three cases of hair loss in a female pattern hair loss (FPHL) distribution with histologic features of lichen planopilaris (LPP). All patients had a history of diffuse, gradual hair loss in a Christmas tree pattern that clinically presented as FPHL on gross and dermoscopic examination. Notably, there were no characteristic clinical signs of LPP and no histologic features of FPHL. These cases are most consistent with cicatricial pattern hair loss (CPHL). This relatively new entity is similar to fibrosing alopecia in a pattern distribution (FAPD) in that they are both scarring alopecias confined to a FPHL distribution, but CPHL lacks the clinical signs of perifollicular erythema and perifollicular keratosis seen in FAPD. These three cases may present an early, subtle form of CPHL and will be of interest to clinicians and histopathologists alike.
Assuntos
Alopecia/patologia , Cicatriz/patologia , Líquen Plano/patologia , Adulto , Idoso , Alopecia/complicações , Alopecia/diagnóstico por imagem , Cicatriz/complicações , Cicatriz/diagnóstico por imagem , Dermoscopia , Feminino , Humanos , Líquen Plano/complicações , Líquen Plano/diagnóstico por imagemAssuntos
Antineoplásicos , Carcinoma Basocelular , Neoplasias Cutâneas , Humanos , Carcinoma Basocelular/tratamento farmacológico , Carcinoma Basocelular/patologia , Piridinas/uso terapêutico , Compostos de Bifenilo/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/patologia , Antineoplásicos/uso terapêuticoRESUMO
An 85-year-old man presented with an ulcerated pruritic nodule on the scalp. Histology of a deep curette specimen showed the typical features of a squamoid eccrine ductal carcinoma: superficial squamous differentiation and deep ductal structures.
Assuntos
Carcinoma de Células Escamosas/patologia , Glândulas Écrinas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Neoplasias das Glândulas Sudoríparas/cirurgia , Idoso de 80 Anos ou mais , Biópsia por Agulha , Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Células Epiteliais/patologia , Humanos , Imuno-Histoquímica , Masculino , Prurido/diagnóstico , Prurido/etiologia , Doenças Raras , Medição de Risco , Dermatoses do Couro Cabeludo/diagnóstico , Dermatoses do Couro Cabeludo/etiologia , Neoplasias das Glândulas Sudoríparas/diagnóstico , Resultado do TratamentoAssuntos
Alopecia em Áreas/diagnóstico , Alopecia em Áreas/etiologia , Prazosina/efeitos adversos , Anti-Hipertensivos/efeitos adversos , Anti-Hipertensivos/uso terapêutico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Humanos , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Prazosina/uso terapêuticoRESUMO
Actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma (cSCC) are heterogeneous keratinocytic skin lesions. Biomarkers that can accurately stratify these lesion types are needed to support a new paradigm of personalized and precise management of skin neoplasia. In this paper, we used a data independent acquisition proteomics workflow, sequential window acquisition of all theoretical mass spectra, to analyze formalin-fixed paraffin-embedded samples of normal skin and keratinocytic skin lesions, including well-differentiated, moderately differentiated and poorly differentiated cSCC lesions. We quantified 3,574 proteins across the 93 samples studied. Differential abundance analysis identified 19, 5, and 6 protein markers exclusive to actinic keratosis, Bowen's disease and cSCC lesions, respectively. Among cSCC lesions of various levels of tumor differentiation, 118, 230, and 17 proteins showed a potential as biomarkers of well-differentiated, moderately differentiated and poorly differentiated cSCC lesions, respectively. Bioinformatics analysis revealed that actinic keratosis and cSCC lesions were associated with decreased apoptosis, and Bowen's disease lesions with over-representation of the DNA damage repair pathway. Differential expression of alternatively spliced FGFR2, Rho guanosine triphosphatase signaling, and RNA metabolism proteins were associated with the level of cSCC tumor differentiation. Proteome profiles also separated keratinocytic skin lesion subtypes on principal components analysis. Overall, protein markers have excellent potential to discriminate keratinocytic skin lesion subtypes and facilitate new diagnostic and therapeutic strategies.