Detalhe da pesquisa
1.
Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis.
J Enzyme Inhib Med Chem
; 38(1): 387-397, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36446617
2.
DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway.
Bioorg Med Chem Lett
; 73: 128915, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35917835
3.
Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.
Bioorg Chem
; 128: 106087, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970069
4.
Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library.
Bioorg Chem
; 119: 105581, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34990933
5.
Screening of Big Pharma's Library against Various in-house Biological Targets.
Molecules
; 27(14)2022 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35889355
6.
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.
Chembiochem
; 22(4): 743-753, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030752
7.
Mur ligases inhibitors with azastilbene scaffold: Expanding the structure-activity relationship.
Bioorg Med Chem Lett
; 40: 127966, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744441
8.
Synthesis and Evaluation of Antioxidant Properties of 2-Substituted Quinazolin-4(3H)-ones.
Molecules
; 26(21)2021 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34770996
9.
Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases.
J Enzyme Inhib Med Chem
; 34(1): 1010-1017, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072165
10.
Application of the N-Dibenzyl Protective Group in the Preparation of ß-Lactam Pseudopeptides.
Molecules
; 24(7)2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939731
11.
Heterocyclic electrophiles as new MurA inhibitors.
Arch Pharm (Weinheim)
; 351(12): e1800184, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30461051
12.
Synthesis and structure-activity relationship study of novel quinazolinone-based inhibitors of MurA.
Bioorg Med Chem Lett
; 27(15): 3529-3533, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28579123
13.
Discovery of new MurA inhibitors using induced-fit simulation and docking.
Bioorg Med Chem Lett
; 27(4): 944-949, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28077258
14.
Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides.
Mol Divers
; 20(3): 667-76, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017352
15.
Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC-MurF): experimental and computational characterization.
J Comput Aided Mol Des
; 29(6): 541-60, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25851408
16.
Inhibitor design strategy based on an enzyme structural flexibility: a case of bacterial MurD ligase.
J Chem Inf Model
; 54(5): 1451-66, 2014 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24724969
17.
Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF).
Bioorg Med Chem
; 22(15): 4124-34, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24953950
18.
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.
Bioorg Chem
; 55: 2-15, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755374
19.
Biochemical characterization of MurF from Streptococcus pneumoniae and the identification of a new MurF inhibitor through ligand-based virtual screening.
Acta Chim Slov
; 60(2): 294-9, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23878932
20.
Inhibition of MurA Enzyme from Escherichia coli by Flavonoids and Their Synthetic Analogues.
ACS Omega
; 8(36): 33006-33016, 2023 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37720776