Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours.

de Weger, Vincent A; de Jonge, Maja; Langenberg, Marlies H G; Schellens, Jan H M; Lolkema, Martijn; Varga, Andrea; Demers, Brigitte; Thomas, Koruth; Hsu, Karl; Tuffal, Gilles; Goodstal, Samantha; Macé, Sandrine; Deutsch, Eric.

Br J Cancer ; 120(3): 286-293, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30585255

2.

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

Liu, Ting Xi; Becker, Michael W; Jelinek, Jaroslav; Wu, Wen-Shu; Deng, Min; Mikhalkevich, Natallia; Hsu, Karl; Bloomfield, Clara D; Stone, Richard M; DeAngelo, Daniel J; Galinsky, Ilene A; Issa, Jean-Pierre; Clarke, Michael F; Look, A Thomas.

Nat Med ; 13(1): 78-83, 2007 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17159988

3.

Challenges to Using Big Data in Cancer.

Sweeney, Shawn M; Hamadeh, Hisham K; Abrams, Natalie; Adam, Stacey J; Brenner, Sara; Connors, Dana E; Davis, Gerard J; Fiore, Louis; Gawel, Susan H; Grossman, Robert L; Hanlon, Sean E; Hsu, Karl; Kelloff, Gary J; Kirsch, Ilan R; Louv, Bill; McGraw, Deven; Meng, Frank; Milgram, Daniel; Miller, Robert S; Morgan, Emily; Mukundan, Lata; O'Brien, Thomas; Robbins, Paul; Rubin, Eric H; Rubinstein, Wendy S; Salmi, Liz; Schaller, Teilo; Shi, George; Sigman, Caroline C; Srivastava, Sudhir.

Cancer Res ; 83(8): 1175-1182, 2023 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-36625843

4.

Case Studies for Overcoming Challenges in Using Big Data in Cancer.

Sweeney, Shawn M; Hamadeh, Hisham K; Abrams, Natalie; Adam, Stacey J; Brenner, Sara; Connors, Dana E; Davis, Gerard J; Fiore, Louis D; Gawel, Susan H; Grossman, Robert L; Hanlon, Sean E; Hsu, Karl; Kelloff, Gary J; Kirsch, Ilan R; Louv, Bill; McGraw, Deven; Meng, Frank; Milgram, Daniel; Miller, Robert S; Morgan, Emily; Mukundan, Lata; O'Brien, Thomas; Robbins, Paul; Rubin, Eric H; Rubinstein, Wendy S; Salmi, Liz; Schaller, Teilo H; Shi, George; Sigman, Caroline C; Srivastava, Sudhir.

Cancer Res ; 83(8): 1183-1190, 2023 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-36625851

5.

A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors.

Holen, Kyle; DiPaola, Robert; Liu, Glenn; Tan, Antoinette R; Wilding, George; Hsu, Karl; Agrawal, Nancy; Chen, Cong; Xue, Lingling; Rosenberg, Elizabeth; Stein, Mark.

Invest New Drugs ; 30(3): 1088-95, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21424701

6.

Turning on a dimer: new insights into MLL chimeras.

Hsu, Karl; Look, A Thomas.

Cancer Cell ; 4(2): 81-3, 2003 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-12957280

7.

CD47-blocking Antibody ZL-1201 Promotes Tumor-associated Macrophage Phagocytic Activity and Enhances the Efficacy of the Therapeutic Antibodies and Chemotherapy.

Cao, Anthony; Yi, Jiaqing; Tang, Xinyan; Szeto, Christopher W; Wu, Renyi; Wan, Bing; Fang, Xu; Li, Shou; Wang, Lei; Wang, Lina; Li, Jing; Ye, Qiuping; Huang, Tom; Hsu, Karl; Kabbarah, Omar; Zhou, Haiying.

Cancer Res Commun ; 2(11): 1404-1417, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36970051

8.

ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell-mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models.

Konno, Hiroyasu; Lin, Tracey; Wu, Renyi; Dai, Xinchuan; Li, Shou; Wang, Grace; Chen, Min; Li, Wenying; Wang, Lina; Sun, Bee-Chun; Luo, Zhen; Huang, Tom; Chen, Yuping; Zhang, John; Ye, Qiuping; Bellovin, David; Wan, Bing; Kang, Lishan; Szeto, Christopher; Hsu, Karl; Kabbarah, Omar.

Cancer Res Commun ; 2(9): 937-950, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36922936

9.

The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish.

Amigo, Julio D; Ackermann, Gabriele E; Cope, John J; Yu, Ming; Cooney, Jeffrey D; Ma, Dongdong; Langer, Nathaniel B; Shafizadeh, Ebrahim; Shaw, George C; Horsely, Wyatt; Trede, Nikolaus S; Davidson, Alan J; Barut, Bruce A; Zhou, Yi; Wojiski, Sarah A; Traver, David; Moran, Tyler B; Kourkoulis, George; Hsu, Karl; Kanki, John P; Shah, Dhvanit I; Lin, Hui Feng; Handin, Robert I; Cantor, Alan B; Paw, Barry H.

Blood ; 114(21): 4654-63, 2009 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-19729519

10.

Pre-clinical development of a novel CD3-CD123 bispecific T-cell engager using cross-over dual-variable domain (CODV) format for acute myeloid leukemia (AML) treatment.

Bonnevaux, Hélène; Guerif, Stephane; Albrecht, Jana; Jouannot, Erwan; De Gallier, Thibaud; Beil, Christian; Lange, Christian; Leuschner, Wulf Dirk; Schneider, Marion; Lemoine, Cendrine; Caron, Anne; Amara, Céline; Barrière, Cédric; Siavellis, Justine; Bardet, Valérie; Luna, Ernesto; Agrawal, Pankaj; Drake, Donald R; Rao, Ercole; Wonerow, Peter; Carrez, Chantal; Blanc, Véronique; Hsu, Karl; Wiederschain, Dmitri; Fraenkel, Paula G; Virone-Oddos, Angéla.

Oncoimmunology ; 10(1): 1945803, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34484869

11.

Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models.

Hotz, Christian; Wagenaar, Timothy R; Gieseke, Friederike; Bangari, Dinesh S; Callahan, Michelle; Cao, Hui; Diekmann, Jan; Diken, Mustafa; Grunwitz, Christian; Hebert, Andy; Hsu, Karl; Bernardo, Marie; Karikó, Katalin; Kreiter, Sebastian; Kuhn, Andreas N; Levit, Mikhail; Malkova, Natalia; Masciari, Serena; Pollard, Jack; Qu, Hui; Ryan, Sue; Selmi, Abderaouf; Schlereth, Julia; Singh, Kuldeep; Sun, Fangxian; Tillmann, Bodo; Tolstykh, Tatiana; Weber, William; Wicke, Lena; Witzel, Sonja; Yu, Qunyan; Zhang, Yu-An; Zheng, Gang; Lager, Joanne; Nabel, Gary J; Sahin, Ugur; Wiederschain, Dmitri.

Sci Transl Med ; 13(610): eabc7804, 2021 Sep 08.

Artigo em Inglês | MEDLINE | ID: mdl-34516826

12.

Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.

Rhodes, Jennifer; Hagen, Andreas; Hsu, Karl; Deng, Min; Liu, Ting Xi; Look, A Thomas; Kanki, John P.

Dev Cell ; 8(1): 97-108, 2005 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-15621533

13.

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.

Liu, Ting Xi; Howlett, Niall G; Deng, Min; Langenau, David M; Hsu, Karl; Rhodes, Jennifer; Kanki, John P; D'Andrea, Alan D; Look, A Thomas.

Dev Cell ; 5(6): 903-14, 2003 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-14667412

14.

Phase I trial of isatuximab monotherapy in the treatment of refractory multiple myeloma.

Martin, Thomas; Strickland, Stephen; Glenn, Martha; Charpentier, Eric; Guillemin, Hélène; Hsu, Karl; Mikhael, Joseph.

Blood Cancer J ; 9(4): 41, 2019 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-30926770

15.

Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.

Liu, Ting Xi; Rhodes, Jennifer; Deng, Min; Hsu, Karl; Radomska, Hanna S; Kanki, John P; Tenen, Daniel G; Look, A Thomas.

Exp Hematol ; 35(2): 230-9, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17258072

16.

A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours.

de Jonge, Maja; de Weger, Vincent A; Dickson, Mark A; Langenberg, Marlies; Le Cesne, Axel; Wagner, Andrew J; Hsu, Karl; Zheng, Wei; Macé, Sandrine; Tuffal, Gilles; Thomas, Koruth; Schellens, Jan H M.

Eur J Cancer ; 76: 144-151, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28324749

17.

Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma.

Bechter, Oliver E; Dumez, Herlinde; Costermans, Jo; Punie, Kevin; Hsu, Karl; Dedieu, Jean-François; Ghuysen, Anne-Frédérique; Francesconi, Elisa; Sharma, Jyoti; Liu, Li; Schöffski, Patrick.

Cancer Chemother Pharmacol ; 78(1): 83-90, 2016 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-27169794

18.

Making waves in cancer research: new models in the zebrafish.

Berghmans, Stephane; Jette, Cicely; Langenau, David; Hsu, Karl; Stewart, Rodney; Look, Thomas; Kanki, John P.

Biotechniques ; 39(2): 227-37, 2005 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-16116796

19.

Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: a phase I/II randomized trial.

Moran, Teresa; Felip, Enriqueta; Keedy, Vicki; Borghaei, Hossein; Shepherd, Frances A; Insa, Amelia; Brown, Holly; Fitzgerald, Timothy; Sathyanarayanan, Sriram; Reilly, John F; Mauro, David; Hsu, Karl; Yan, Li; Johnson, David H.

Exp Hematol Oncol ; 3(1): 26, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25414803

20.

A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors.

Atzori, Francesco; Tabernero, Josep; Cervantes, Andrés; Prudkin, Ludmila; Andreu, Jordi; Rodríguez-Braun, Edith; Domingo, Amparo; Guijarro, Jorge; Gamez, Cristina; Rodon, Jordi; Di Cosimo, Serena; Brown, Holly; Clark, Jason; Hardwick, James S; Beckman, Robert A; Hanley, William D; Hsu, Karl; Calvo, Emiliano; Roselló, Susana; Langdon, Ronald B; Baselga, José.

Clin Cancer Res ; 17(19): 6304-12, 2011 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-21810918

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