Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling.

Chen, Miaomiao; Shin, Myungsun; Ware, Timothy B; Donvito, Giulia; Muchhala, Karan H; Mischel, Ryan; Mustafa, Mohammed A; Serbulea, Vlad; Upchurch, Clint M; Leitinger, Norbert; Akbarali, Hamid I; Lichtman, Aron H; Hsu, Ku-Lung.

Proc Natl Acad Sci U S A ; 120(52): e2304900120, 2023 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-38109529

2.

Imidazoles are tunable nucleofuges for developing tyrosine-reactive electrophiles.

Grams, Robert Justin; Yuan, Kun; Founds, Michael W; Ware, Madeleine L; Pilar, Michael G; Hsu, Ku-Lung.

Chembiochem ; : e202400382, 2024 May 31.

Artigo em Inglês | MEDLINE | ID: mdl-38819848

3.

Global Discovery of Covalent Modulators of Ribonucleoprotein Granules.

Ciancone, Anthony M; Seo, Kyung W; Chen, Miaomiao; Borne, Adam L; Libby, Adam H; Bai, Dina L; Kleiner, Ralph E; Hsu, Ku-Lung.

J Am Chem Soc ; 145(20): 11056-11066, 2023 05 24.

Artigo em Inglês | MEDLINE | ID: mdl-37159397

4.

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.

Georgiev, Georgi A; Gh, Mohammad Sharifian; Romano, Jeff; Dias Teixeira, Karina L; Struble, Craig; Ryan, Denise S; Sia, Rose K; Kitt, Jay P; Harris, Joel M; Hsu, Ku-Lung; Libby, Adam; Odrich, Marc G; Suárez, Tatiana; McKown, Robert L; Laurie, Gordon W.

J Biol Chem ; 296: 100070, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33187980

5.

Global targeting of functional tyrosines using sulfur-triazole exchange chemistry.

Hahm, Heung Sik; Toroitich, Emmanuel K; Borne, Adam L; Brulet, Jeffrey W; Libby, Adam H; Yuan, Kun; Ware, Timothy B; McCloud, Rebecca L; Ciancone, Anthony M; Hsu, Ku-Lung.

Nat Chem Biol ; 16(2): 150-159, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31768034

6.

Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering.

Ware, Timothy B; Franks, Caroline E; Granade, Mitchell E; Zhang, Mingxing; Kim, Kee-Beom; Park, Kwon-Sik; Gahlmann, Andreas; Harris, Thurl E; Hsu, Ku-Lung.

Nat Chem Biol ; 16(2): 170-178, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31932721

7.

Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics.

McCloud, Rebecca L; Yuan, Kun; Mahoney, Keira E; Bai, Dina L; Shabanowitz, Jeffrey; Ross, Mark M; Hunt, Donald F; Hsu, Ku-Lung.

Anal Chem ; 93(35): 11946-11955, 2021 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-34431655

8.

Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2.

Toroitich, Emmanuel K; Ciancone, Anthony M; Hahm, Heung Sik; Brodowski, Skylar M; Libby, Adam H; Hsu, Ku-Lung.

Chembiochem ; 22(12): 2134-2139, 2021 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-33861519

9.

Liganding Functional Tyrosine Sites on Proteins Using Sulfur-Triazole Exchange Chemistry.

Brulet, Jeffrey W; Borne, Adam L; Yuan, Kun; Libby, Adam H; Hsu, Ku-Lung.

J Am Chem Soc ; 142(18): 8270-8280, 2020 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-32329615

10.

Automated Spatially Targeted Optical Microproteomics (autoSTOMP) to Determine Protein Complexity of Subcellular Structures.

Yin, Bocheng; Mendez, Roberto; Zhao, Xiao-Yu; Rakhit, Rishi; Hsu, Ku-Lung; Ewald, Sarah E.

Anal Chem ; 92(2): 2005-2010, 2020 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-31869197

11.

Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling.

Borne, Adam L; Huang, Tao; McCloud, Rebecca L; Pachaiyappan, Boobalan; Bullock, Timothy N J; Hsu, Ku-Lung.

Curr Top Microbiol Immunol ; 420: 175-210, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30128827

12.

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase.

Lazo, John S; Blanco, Isabella K; Tasker, Nikhil R; Rastelli, Ettore J; Burnett, James C; Garrott, Sharon R; Hart, Duncan J; McCloud, Rebecca L; Hsu, Ku-Lung; Wipf, Peter; Sharlow, Elizabeth R.

J Pharmacol Exp Ther ; 371(3): 652-662, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31601683

13.

Catch your breath.

Grams, R Justin; Hsu, Ku-Lung.

Nat Chem Biol ; 18(7): 686-687, 2022 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-35710618

14.

Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure.

Buczynski, Matthew W; Herman, Melissa A; Hsu, Ku-Lung; Natividad, Luis A; Irimia, Cristina; Polis, Ilham Y; Pugh, Holly; Chang, Jae Won; Niphakis, Micah J; Cravatt, Benjamin F; Roberto, Marisa; Parsons, Loren H.

Proc Natl Acad Sci U S A ; 113(4): 1086-91, 2016 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-26755579

15.

Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics.

McCloud, Rebecca L; Franks, Caroline E; Campbell, Sean T; Purow, Benjamin W; Harris, Thurl E; Hsu, Ku-Lung.

Biochemistry ; 57(2): 231-236, 2018 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-29155586

16.

Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.

Campbell, Sean T; Franks, Caroline E; Borne, Adam L; Shin, Myungsun; Zhang, Liuzhi; Hsu, Ku-Lung.

Mol Pharmacol ; 94(5): 1246-1255, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30158316

17.

Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy.

Curry, Zachary A; Wilkerson, Jenny L; Bagdas, Deniz; Kyte, S Lauren; Patel, Nipa; Donvito, Giulia; Mustafa, Mohammed A; Poklis, Justin L; Niphakis, Micah J; Hsu, Ku-Lung; Cravatt, Benjamin F; Gewirtz, David A; Damaj, M Imad; Lichtman, Aron H.

J Pharmacol Exp Ther ; 366(1): 169-183, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29540562

18.

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.

Shin, Myungsun; Snyder, Helena W; Donvito, Giulia; Schurman, Lesley D; Fox, Todd E; Lichtman, Aron H; Kester, Mark; Hsu, Ku-Lung.

Mol Pharm ; 15(3): 721-728, 2018 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-28901776

19.

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

Yun, Bogeon; Lee, HeeJung; Powell, Roger; Reisdorph, Nichole; Ewing, Heather; Gelb, Michael H; Hsu, Ku-Lung; Cravatt, Benjamin F; Leslie, Christina C.

Biochem Biophys Res Commun ; 490(4): 1226-1231, 2017 09 02.

Artigo em Inglês | MEDLINE | ID: mdl-28684316

20.

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase.

Inloes, Jordon M; Hsu, Ku-Lung; Dix, Melissa M; Viader, Andreu; Masuda, Kim; Takei, Thais; Wood, Malcolm R; Cravatt, Benjamin F.

Proc Natl Acad Sci U S A ; 111(41): 14924-9, 2014 Oct 14.

Artigo em Inglês | MEDLINE | ID: mdl-25267624

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