Detalhe da pesquisa
1.
Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors.
Bioorg Chem
; 121: 105669, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35180490
2.
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in ß-tubulin.
J Biol Chem
; 293(24): 9461-9472, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691282
3.
Molecular dynamics simulations of the conformational plasticity in the active pocket of salt-inducible kinase 2 (SIK2) multi-state binding with bosutinib.
Comput Struct Biotechnol J
; 20: 2574-2586, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35685353
4.
Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.
Blood Cancer J
; 12(3): 37, 2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35256594
5.
A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids.
Drug Deliv
; 28(1): 1055-1066, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34078185
6.
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
J Med Chem
; 63(23): 14921-14936, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33256400
7.
Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms.
J Med Chem
; 62(22): 10305-10320, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31670517
8.
Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
Eur J Med Chem
; 178: 116-130, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31177073
9.
Discovery of novel ß-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance.
Eur J Med Chem
; 152: 516-526, 2018 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29754076
10.
Correction to "N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms".
J Med Chem
; 64(4): 2310, 2021 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33591746
11.
Correction to "Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms".
J Med Chem
; 63(3): 1441-1442, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31985218