Soil moisture decline in China's monsoon loess critical zone: More a result of land-use conversion than climate change.

Soil moisture (SM) is essential for sustaining services from Earth's critical zone, a thin-living skin spanning from the canopy to groundwater. In the Anthropocene epoch, intensive afforestation has remarkably contributed to global greening and certain service improvements, often at the cost of reduced SM. However, attributing the response of SM in deep soil to such human activities is a great challenge because of the scarcity of long-term observations. Here, we present a 37 y (1985 to 2021) analysis of SM dynamics at two scales across China's monsoon loess critical zone. Site-scale data indicate that land-use conversion from arable cropland to forest/grassland caused an 18% increase in SM deficit over 0 to 18 m depth (P < 0.01). Importantly, this SM deficit intensified over time, despite limited climate change influence. Across the Loess Plateau, SM storage in 0 to 10 m layer exhibited a significant decreasing trend from 1985 to 2021, with a turning point in 1999 when starting afforestation. Compared with SM storage before 1999, the relative contributions of climate change and afforestation to SM decline after 1999 were -8% and 108%, respectively. This emphasizes the pronounced impacts of intensifying land-use conversions as the principal catalyst of SM decline. Such a decline shifts 18% of total area into an at-risk status, mainly in the semiarid region, thereby threatening SM security. To mitigate this risk, future land management policies should acknowledge the crucial role of intensifying land-use conversions and their interplay with climate change. This is imperative to ensure SM security and sustain critical zone services.

Development and Validation of a Prognostic Model for Postoperative Anastomotic Recurrence in Siewert II or III Adenocarcinomas Without Neoadjuvant Therapy in an East Asian Population.

PURPOSE: Anastomotic recurrence leads to poor prognosis in patients with Siewert II or III adenocarcinoma who undergo radical gastrectomy and do not receive neoadjuvant therapy. We aimed to establish a prognostic model to evaluate the risk of postoperative anastomotic recurrence in patients with Siewert II or III adenocarcinoma who did not receive neoadjuvant therapy. METHODS: We included 366 patients with Siewert II or III adenocarcinoma who were treated with radical gastrectomy without neoadjuvant therapy at Fujian Provincial Hospital (FPH) between 2012 and 2018 as the development cohort. Cox regression was used to verify prognostic factors for anastomotic recurrence, and a nomogram was established. The nomogram was externally validated using a combined cohort of two external centers. Patients were classified into high- or low-risk groups according to the diagnostic threshold and nomogram scores, and recurrence-related survival analysis was analyzed. RESULTS: The average age was 64.6 years, and 285 patients were male. All surgeries were successfully performed (185 open vs 181 laparoscopic). The 3-year anastomotic recurrence rate was significantly lower in the low-risk group (3.5% vs 18.8%, P < 0.001). The predictive performance was verified in the external validation cohort. This model better stratified patient survival than the American Joint Committee on Cancer (AJCC) TNM staging system. CONCLUSIONS: This novel nomogram with surgical margin, postoperative tumor node metastasis (pTNM) stage, and neural invasion as prognostic factors has a significant predictive performance for the risk of anastomotic recurrence after radical gastrectomy in patients with Siewert II or III adenocarcinoma.

Intraoperative Diagnosis of Serosal Invasion in Gastric Cancer by Magnifying Endoscopy with Narrow-Band Imaging for Intraoperative Measurement Decision.

Purpose: To establish a precise diagnostic method for serosal invasion in gastric cancer (GC) during surgery using therapeutic measures, and facilitate quick decision-making. Methods: A total of 19 GC patients treated in the department of gastrointestinal surgery of Fujian Provincial Hospital between April 2019 and December 2020 were enrolled. An electronic gastroscopy with a magnifying endoscope with narrow-band imaging was used to photograph the serosal surface of the GC lesion site and the normal gastric wall around the lesion during surgery. The endoscopic diagnosis was confirmed on the basis of the microvascular phenotype of the serosal surface and validated by comparison with the pathological diagnosis. Results: Under the specific endoscopy, serosal invasion, including subserosal tissue invasion and serosal layer invasion, was diagnosed by observing the capillary morphology change, and capillary diameter and density increase. According to the pathological diagnosis, the accuracy of serosal invasion diagnosis was 94.7%, the sensitivity was 100%, the specificity was 75%, the positive predictive value was 93.8%, and the negative predictive value was 100%. To further distinguish the subserosal tissue invasion and serosal layer invasion, the magnifying endoscope with narrow-band imaging possessed a 78.9% accuracy by distinguishing irregular changes in microvessels. Conclusions: Magnifying endoscope with narrow-band imaging is less time-consuming than pathological diagnosis. Intraoperative diagnosis using microvascular observation can accurately detect serosal invasion. It is of value for the intraoperative diagnosis in GC patients.

Vehicle-Free Nanotheranostic Self-Assembled from Clinically Approved Dyes for Cancer Fluorescence Imaging and Photothermal/Photodynamic Combinational Therapy.

Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted growing attention as a noninvasive option for cancer treatment. At present, researchers have developed various "all-in-one" nanoplatforms for cancer imaging and PTT/PDT combinational therapy. However, the complex structure, tedious preparation procedures, overuse of extra carriers and severe side effects hinder their biomedical applications. In this work, we reported a nanoplatform (designated as ICG-MB) self-assembly from two different FDA-approved dyes of indocyanine green (ICG) and methylene blue (MB) without any additional excipients for cancer fluorescence imaging and combinational PTT/PDT. ICG-MB was found to exhibit good dispersion in the aqueous phase and improve the photostability and cellular uptake of free ICG and MB, thus exhibiting enhanced photothermal conversion and singlet oxygen (1O2) generation abilities to robustly ablate cancer cells under 808 nm and 670 nm laser irradiation. After intravenous injection, ICG-MB effectively accumulated at tumor sites with a near-infrared (NIR) fluorescence signal, which helped to delineate the targeted area for NIR laser-triggered phototoxicity. As a consequence, ICG-MB displayed a combinational PTT/PDT effect to potently inhibit tumor growth without causing any system toxicities in vivo. In conclusion, this minimalist, effective and biocompatible nanotheranostic would provide a promising candidate for cancer phototherapy based on current available dyes in clinic.

Simulating nitrate release from an unsaturated coal waste rock dump.

Knowledge of the controls affecting the release of contaminants from waste rock dumps is critical for developing strategies to mitigate downstream impacts on water quality. In this study, a three-dimensional model of a large coal waste rock dump constructed in the Elk Valley, British Columbia, Canada was developed to capture the impact of construction history (1981-2012) and solute transport on nitrate (NO3-) release over a 100-year timeframe. The model consisted of 21, one-dimensional finite element models that represented the temporal evolution of the dump. Nitrate, derived from undetonated blast products, was assumed to be present at the time of waste rock placement and was simulated as a conservative species. The simulated pattern of NO3- release to the surface water receptor occurred approximately 8 years before its measured arrival. This time lag is attributed to displacement of the water within a basal alluvial aquifer by dump effluent. The simulated patterns of historic releases corrected for the 8-year time lag, compare favourably with monitoring data and suggest the dominant hydrogeological and geochemical mechanisms are captured in the model. The model indicated the flushing of NO3- from the dump should be complete by about 2042 with a peak effluent concentration of NO3- in 2008. The addition of reclamation covers to the model resulted in an immediate decrease in the annual NO3- loading rate but extended the time frame for NO3- release from the dump relative to the no cover case. The model also showed that the timing of cover placement had little impact on NO3- release relative to the no cover case due to long duration of waste rock placement (~30 years) over a relatively large footprint.

[Regulation effect of forest vegetation on watershed runoff in the Loess Plateau].

The runoff and rainfall data of typical forested and non-forested watersheds in Ziwuling region, which is located in the hinterland of the Loess Plateau, were used to analyze their annual runoff variation comparatively. The result showed that the annual distribution of runoff in forested watersheds was uniform, compared with that in non-forested watersheds. The total runoff in flood season decreased by 8.88 mm and 7.1 mm. Regression analyses between runoff in dried-up season and rainfall in flood season or in dried-up season showed that the rainfall in flood season in forested watersheds could be changed into underground runoff by forest vegetation, and increased the runoff in dried-up season. The annual variation of runoff also indicated that the total effect of forest vegetation on dried-up runoff complement from October to December was 1.69 mm and 0.5 mm, and that from January to May was not significant.

[Benefit of sediment reduction by biological measures in the watershed scale].

Based on the measured data and the model of plotted watershed hydrology, the benefit of sediment reduction by biological harnesses of soil and water conservation was studied in the watershed scale. The result indicated that the erosion modulus in Wangdonggou watershed, which were 1869 t.km-2, 1050 t.km-2, 383 t.km-2, and 504 t.km-2 in the periods of the sixth, seventh, eighth, and ninth five-year plans, respectively, were gradually reduced by comprehensive measures. Taken out the effect of rainfall, the sediment reduction by biological measures of soil and water conservation was increased by 24.1% and 22.4% in the periods of eighth and ninth five-year plans compared to that in the seventh five-year plan.