Prognostic factors for ovarian metastases in colorectal cancer patients.

PURPOSE: The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scoring system for prognosis of OM of CRC patients after surgery. PATIENTS AND METHODS: Data of CRC patients with OM were collected from a single Chinese institution (n = 67). Kaplan-Meier analysis was used to evaluate cumulative survival of patients. Factors associated with prognosis of overall survival (OS) were explored using Cox's proportional hazard regression models. A scoring system to determine effectiveness of prognosis was developed. RESULTS: Median OS values for patients with or without surgery were 22 and 7 months, respectively. Size of OM, number of OM, peritoneal metastasis (PM), Peritoneal cancer index (PCI), and completeness of cytoreduction (CC) were associated with OS of patients through univariate analysis. Multivariate analysis using a Cox regression model showed that only CC was an independent predictor for OS. Three variables (the size of OM >15cm, PCI ≥ 10, and carcinoembryonic antigen (CEA) >30 ng/mL) assigned one point each were used to develop a risk score. The resulting score was used for prognosis of OS. CONCLUSION: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis. The scoring system developed in this study is effective for prediction of OS of patients after surgery.

Childhood psychological abuse and relational aggression among adolescents: A moderated chain mediation model.

Introduction: Adolescents are in a period when a marked upward trend of adolescents relational aggression. Even though previous studies have found that childhood psychological abuse experience is an important factor influencing adolescent relational aggression, it is unclear when and under what circumstances childhood psychological abuse impacts adolescent relational aggression. This study constructed a moderated chain mediation model to investigate the influence of childhood psychological abuse on relational aggression among Chinese adolescents and its internal mechanism. Methods: Data from 1868 (923 male and 945 female, M = 14.31, SD = 1.60) Chinese adolescents in two full-time middle schools in Guangzhou were collected via a cross-sectional survey in 2020. Adolescents reported on childhood psychological abuse, relational aggression, rejection sensitivity relational victimization and cognitive reappraisal. Results: The results demonstrated that: (1) childhood psychological abuse was significantly positively related to relational aggression; (2) childhood psychological abuse was significantly linked with adolescents' relational aggression through the separate mediating effects of rejection sensitivity and relational victimization, as well as through the chain mediating effects of rejection sensitivity and relational victimization; (3) the chain mediated effect of childhood psychological abuse on relational aggression through rejection sensitivity and relational victimization was moderated by cognitive reappraisal. Conclusion: These findings indicate that childhood psychological abuse, as a kind of poor parenting style, has influence on adolescents' internal personality (rejection sensitivity) and external behavior development (relational victimization and relational aggression). This study is helpful to demonstrate the protective effect of cognitive reappraisal and reveal the internal mechanism of childhood psychological abuse on relational aggression.

Factors Prognostic for Brain Metastases from Colorectal Cancer: A Single-Center Experience in China.

PURPOSE: This study aimed to analyze clinicopathological, survival, prognostic factors, as well as the timing of brain metastases (BM) in colorectal cancer (CRC) using data from a Chinese center. PATIENTS AND METHODS: Data of 65 consecutive CRC patients with BM were collected from a single institution in China. The time from primary tumor surgery to the occurrence of BM was calculated. Kaplan-Meier analysis was used to evaluate cumulative survival of patients. Factors associated with prognosis of overall survival (OS) were explored using Cox's proportional hazard regression models. RESULTS: The median time interval from CRC surgery to the diagnosis of BM was 24 months. After diagnosis of BM, median OS values for patients were 11 months. Extracranial metastases occurred in 45 cases (69.2%) when BM was diagnosed, and 58.5% of these patients with lung metastases Time of BMs (P=0.018), presence of extracranial metastases (P=0.033), treatment (P=0.003), CA199 (P=0.034), CA125 (P<0.001), CA242 (P=0.018), and CA211 (P=0.012) were associated with OS of patients through univariate analysis. Multivariate analysis using a Cox regression model showed that only treatment was an independent predictor for OS (conservative treatment; HR=1.861, 95% CI=1.077-3.441; P=0.048). CONCLUSION: Surgical treatment of metastatic lesions may be an alternative choice for CRC patients with BM. Identifying the timing of brain metastases can help to detect this disease early, leading to a better survival outcome.

Childhood Maltreatment and Mobile Phone Addiction Among Chinese Adolescents: Loneliness as a Mediator and Self-Control as a Moderator.

Previous studies have found that childhood maltreatment is an important risk predictor of adolescent mobile phone addiction (MPA). However, little is known about the mediating and moderating mechanisms underlying this association. Grounded in the Basic Psychological Needs Theory and the organism-environment interaction model, this study examined the mediating effect of loneliness and the moderating effect of self-control in the relationship between childhood maltreatment and adolescent MPA. A total of 981 Chinese adolescents (Mage = 13.68 years, SD = 0.92) completed measures regarding childhood maltreatment, MPA, loneliness, and self-control. After controlling for participants' demographic variables, loneliness partially mediated the relation between childhood maltreatment and adolescent MPA and this indirect path was moderated by self-control. Specifically, the effect of loneliness on MPA was stronger for adolescents with lower self-control than for those with higher self-control. Our research provides additional evidence for the negative association between childhood maltreatment and MPA.