Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer.

Park, Matthew D; Reyes-Torres, Ivan; LeBerichel, Jessica; Hamon, Pauline; LaMarche, Nelson M; Hegde, Samarth; Belabed, Meriem; Troncoso, Leanna; Grout, John A; Magen, Assaf; Humblin, Etienne; Nair, Achuth; Molgora, Martina; Hou, Jinchao; Newman, Jenna H; Farkas, Adam M; Leader, Andrew M; Dawson, Travis; D'Souza, Darwin; Hamel, Steven; Sanchez-Paulete, Alfonso Rodriguez; Maier, Barbara; Bhardwaj, Nina; Martin, Jerome C; Kamphorst, Alice O; Kenigsberg, Ephraim; Casanova-Acebes, Maria; Horowitz, Amir; Brown, Brian D; De Andrade, Lucas Ferrari; Colonna, Marco; Marron, Thomas U; Merad, Miriam.

Nat Immunol ; 24(5): 792-801, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37081148

2.

CXCR3-CXCL9: It's All in the Tumor.

Humblin, Etienne; Kamphorst, Alice O.

Immunity ; 50(6): 1347-1349, 2019 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-31216458

3.

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Bruchard, Mélanie; Rebé, Cédric; Derangère, Valentin; Togbé, Dieudonnée; Ryffel, Bernhard; Boidot, Romain; Humblin, Etienne; Hamman, Arlette; Chalmin, Fanny; Berger, Hélène; Chevriaux, Angélique; Limagne, Emeric; Apetoh, Lionel; Végran, Frédérique; Ghiringhelli, François.

Nat Immunol ; 16(8): 859-70, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26098997

4.

Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Bruchard, Mélanie; Rebé, Cédric; Derangère, Valentin; Togbé, Dieudonnée; Ryffel, Bernhard; Boidot, Romain; Humblin, Etienne; Hamman, Arlette; Chalmin, Fanny; Berger, Hélène; Chevriaux, Angélique; Limagne, Emeric; Apetoh, Lionel; Végran, Frédérique; Ghiringhelli, François.

Nat Immunol ; 16(12): 1292, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26580508

5.

Functional impairment of "helpless" CD8 ⁺ memory T cells is transient and driven by prolonged but finite cognate antigen presentation.

van der Heide, Verena; Davenport, Bennett; Cubitt, Beatrice; Roudko, Vladimir; Choo, Daniel; Humblin, Etienne; Jhun, Kevin; Angeliadis, Krista; Dawson, Travis; Furtado, Glaucia; Kamphorst, Alice; Ahmed, Rafi; de la Torre, Juan Carlos; Homann, Dirk.

bioRxiv ; 2024 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-38328184

6.

Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1⁺ PD-1⁺ CD8 T cells.

Humblin, Etienne; Korpas, Isabel; Lu, Jiahua; Filipescu, Dan; van der Heide, Verena; Goldstein, Simon; Vaidya, Abishek; Soares-Schanoski, Alessandra; Casati, Beatrice; Selvan, Myvizhi E; Gümüs, Zeynep H; Wieland, Andreas; Corrado, Mauro; Cohen-Gould, Leona; Bernstein, Emily; Homann, Dirk; Chipuk, Jerry; Kamphorst, Alice O.

Sci Immunol ; 8(86): eadg0878, 2023 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-37624910

7.

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.

Filipescu, Dan; Carcamo, Saul; Agarwal, Aman; Tung, Navpreet; Humblin, Étienne; Goldberg, Matthew S; Vyas, Nikki S; Beaumont, Kristin G; Demircioglu, Deniz; Sridhar, Subhasree; Ghiraldini, Flavia G; Capparelli, Claudia; Aplin, Andrew E; Salmon, Hélène; Sebra, Robert; Kamphorst, Alice O; Merad, Miriam; Hasson, Dan; Bernstein, Emily.

Nat Cell Biol ; 25(9): 1332-1345, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37605008

8.

Intratumoral dendritic cell-CD4⁺ T helper cell niches enable CD8⁺ T cell differentiation following PD-1 blockade in hepatocellular carcinoma.

Magen, Assaf; Hamon, Pauline; Fiaschi, Nathalie; Soong, Brian Y; Park, Matthew D; Mattiuz, Raphaël; Humblin, Etienne; Troncoso, Leanna; D'souza, Darwin; Dawson, Travis; Kim, Joel; Hamel, Steven; Buckup, Mark; Chang, Christie; Tabachnikova, Alexandra; Schwartz, Hara; Malissen, Nausicaa; Lavin, Yonit; Soares-Schanoski, Alessandra; Giotti, Bruno; Hegde, Samarth; Ioannou, Giorgio; Gonzalez-Kozlova, Edgar; Hennequin, Clotilde; Le Berichel, Jessica; Zhao, Zhen; Ward, Stephen C; Fiel, Isabel; Kou, Baijun; Dobosz, Michael; Li, Lianjie; Adler, Christina; Ni, Min; Wei, Yi; Wang, Wei; Atwal, Gurinder S; Kundu, Kunal; Cygan, Kamil J; Tsankov, Alexander M; Rahman, Adeeb; Price, Colles; Fernandez, Nicolas; He, Jiang; Gupta, Namita T; Kim-Schulze, Seunghee; Gnjatic, Sacha; Kenigsberg, Ephraim; Deering, Raquel P; Schwartz, Myron; Marron, Thomas U.

Nat Med ; 29(6): 1389-1399, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37322116

9.

Advancing beyond the twists and turns of T cell exhaustion in cancer.

van der Heide, Verena; Humblin, Etienne; Vaidya, Abishek; Kamphorst, Alice Oliffson.

Sci Transl Med ; 14(670): eabo4997, 2022 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-36350991

10.

Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects.

Mary, Romain; Chalmin, Fanny; Accogli, Théo; Bruchard, Mélanie; Hibos, Christophe; Melin, Joséphine; Truntzer, Caroline; Limagne, Emeric; Derangère, Valentin; Thibaudin, Marion; Humblin, Etienne; Boidot, Romain; Chevrier, Sandy; Arnould, Laurent; Richard, Corentin; Klopfenstein, Quentin; Bernard, Antoine; Urade, Yoshihiro; Harker, James A; Apetoh, Lionel; Ghiringhelli, François; Végran, Frédérique.

Cancer Immunol Res ; 10(7): 900-916, 2022 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-35612500

11.

PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports.

Collot, Thomas; Niogret, Julie; Carnet, Marion; Chevrier, Sandy; Humblin, Etienne; Favier, Laure; Bengrine-Lefevre, Leila; Desmoulins, Isabelle; Arnould, Laurent; Boidot, Romain.

Mol Med Rep ; 23(1)2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33236159

12.

The Tumor Microenvironment Impairs Th1 IFNÎ³ Secretion through Alternative Splicing Modifications of Irf1 Pre-mRNA.

Bernard, Antoine; Hibos, Christophe; Richard, Corentin; Viltard, Etienne; Chevrier, Sandy; Lemoine, Sophie; Melin, Joséphine; Humblin, Etienne; Mary, Romain; Accogli, Théo; Chalmin, Fanny; Bruchard, Mélanie; Peixoto, Paul; Hervouet, Eric; Apetoh, Lionel; Ghiringhelli, François; Végran, Frédérique; Boidot, Romain.

Cancer Immunol Res ; 9(3): 324-336, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33419764

13.

Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.

Chalmin, Fanny; Humblin, Etienne; Ghiringhelli, François; Végran, Frédérique.

Int Rev Cell Mol Biol ; 341: 1-61, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30262030

14.

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.

Cotte, Alexia Karen; Aires, Virginie; Fredon, Maxime; Limagne, Emeric; Derangère, Valentin; Thibaudin, Marion; Humblin, Etienne; Scagliarini, Alessandra; de Barros, Jean-Paul Pais; Hillon, Patrick; Ghiringhelli, François; Delmas, Dominique.

Nat Commun ; 9(1): 322, 2018 01 22.

Artigo em Inglês | MEDLINE | ID: mdl-29358673

15.

Transcription Factor Binding Studies in CD4+ T Cells: siRNA Transfection, Chromatin Immunoprecipitation, and Liquid Luminescent DNA Precipitation Assay.

Humblin, Etienne; Ghiringhelli, François; Végran, Frédérique.

Methods Mol Biol ; 1585: 167-177, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28477195

16.

T_H9 cells in anti-tumor immunity.

Rivera Vargas, Thaiz; Humblin, Etienne; Végran, Frédérique; Ghiringhelli, François; Apetoh, Lionel.

Semin Immunopathol ; 39(1): 39-46, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27832300

17.

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation.

Limagne, Emeric; Thibaudin, Marion; Euvrard, Romain; Berger, Hélène; Chalons, Pauline; Végan, Frédérique; Humblin, Etienne; Boidot, Romain; Rébé, Cédric; Derangère, Valentin; Ladoire, Sylvain; Apetoh, Lionel; Delmas, Dominique; Ghiringhelli, François.

Cell Rep ; 19(4): 746-759, 2017 04 25.

Artigo em Inglês | MEDLINE | ID: mdl-28445726

18.

IRF8-dependent molecular complexes control the Th9 transcriptional program.

Humblin, Etienne; Thibaudin, Marion; Chalmin, Fanny; Derangère, Valentin; Limagne, Emeric; Richard, Corentin; Flavell, Richard A; Chevrier, Sandy; Ladoire, Sylvain; Berger, Hélène; Boidot, Romain; Apetoh, Lionel; Végran, Frédérique; Ghiringhelli, François.

Nat Commun ; 8(1): 2085, 2017 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-29233972

19.

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

Dufour, Florent; Rattier, Thibault; Constantinescu, Andrei Alexandru; Zischler, Luciana; Morlé, Aymeric; Ben Mabrouk, Hazem; Humblin, Etienne; Jacquemin, Guillaume; Szegezdi, Eva; Delacote, Fabien; Marrakchi, Naziha; Guichard, Gilles; Pellat-Deceunynck, Catherine; Vacher, Pierre; Legembre, Patrick; Garrido, Carmen; Micheau, Olivier.

Oncotarget ; 8(6): 9974-9985, 2017 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-28039489

20.

Exhausted T cells never fully recover.

Reid, Ashley; Humblin, Etienne.

Nat Rev Immunol ; 21(7): 408, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34103705

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