Detalhe da pesquisa
1.
Sialoglycan binding triggers spike opening in a human coronavirus.
Nature
; 624(7990): 201-206, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794193
2.
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.
Proc Natl Acad Sci U S A
; 120(26): e2303292120, 2023 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339194
3.
SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b.
PLoS Pathog
; 19(8): e1011582, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37607209
4.
Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM.
PLoS Biol
; 18(3): e3000649, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231352
5.
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.
PLoS Biol
; 18(11): e3000904, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33156822
6.
Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Proc Natl Acad Sci U S A
; 115(8): 1795-1800, 2018 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29434040
7.
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
Proc Natl Acad Sci U S A
; 115(2): 397-402, 2018 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29284752
8.
Exploring the Effect of Structure-Based Scaffold Hopping on the Inhibition of Coxsackievirus A24v Transduction by Pentavalent N-Acetylneuraminic Acid Conjugates.
Int J Mol Sci
; 22(16)2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445134
9.
Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages.
J Am Chem Soc
; 141(13): 5211-5219, 2019 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30856321
10.
Agnoprotein Is an Essential Egress Factor during BK Polyomavirus Infection.
Int J Mol Sci
; 19(3)2018 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29562663
11.
Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants.
Front Immunol
; 14: 1111385, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36895554
12.
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes.
Nat Commun
; 13(1): 2921, 2022 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35614127
13.
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Sci Adv
; 8(1): eabj7615, 2022 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34985963
14.
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern.
Sci Immunol
; 7(73): eabp9312, 2022 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35471062
15.
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Nat Biotechnol
; 40(12): 1845-1854, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864170
16.
Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11.
Sci Adv
; 7(23)2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33958322
17.
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
Nat Commun
; 12(1): 1715, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33731724
18.
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans.
Nat Commun
; 11(1): 4646, 2020 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32938911
19.
Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37-Viruses That Cause Highly Contagious Eye Infections.
ACS Chem Biol
; 15(10): 2683-2691, 2020 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32845119
20.
Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors.
Antiviral Res
; 178: 104781, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234539