Detalhe da pesquisa
1.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
; 186(4): 786-802.e28, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36754049
2.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
; 184(17): 4547-4563.e17, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314701
3.
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).
Cell
; 184(3): 689-708.e20, 2021 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482083
4.
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.
Pharmacol Rev
; 75(2): 263-308, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549866
5.
Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.
J Neurosci
; 43(2): 333-345, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36446586
6.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
Neurobiol Dis
; 149: 105228, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33359139
7.
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.
Development
; 145(22)2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337375
8.
Probing disorders of the nervous system using reprogramming approaches.
EMBO J
; 34(11): 1456-77, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25925386
9.
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Acta Neuropathol
; 138(1): 49-65, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30945056
10.
Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Acta Neuropathol
; 138(5): 883-884, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31559488
11.
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Nature
; 495(7442): 474-80, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23474986
12.
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.
J Neurosci
; 35(3): 1291-306, 2015 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25609642
13.
Notch inhibition allows oncogene-independent generation of iPS cells.
Nat Chem Biol
; 10(8): 632-639, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24952596
14.
KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury.
Cell Stem Cell
; 31(4): 519-536.e8, 2024 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579683
15.
Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS.
medRxiv
; 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38633814
16.
Shushing down the epigenetic landscape towards stem cell differentiation.
Development
; 137(15): 2455-60, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20554719
17.
Transcriptomic analysis of feeder-free culture system for maintaining naïve-state pluripotency in human pluripotent stem cells.
Stem Cell Investig
; 10: 10, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155477
18.
The C9ORF72 repeat expansion alters neurodevelopment.
Cell Rep
; 42(8): 112983, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37590144
19.
Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD.
Neuron
; 111(9): 1381-1390.e6, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36931278
20.
CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology.
Sci Adv
; 9(45): eadf7997, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948524