RESUMO
A case of acute poisoning by ingestion of water used to debitter lupineseeds, an exceptional occurrence in human clinics, is reported. The patient showed the anticholinergic syndrome for 48 h, which then subsided spontaneously.
Assuntos
Alcaloides/intoxicação , Ingestão de Líquidos , Fabaceae , Plantas Medicinais , Sementes , Doença Aguda , Adulto , Alcaloides/análise , Humanos , Masculino , Esparteína/análogos & derivados , Nervo Trigêmeo/efeitos dos fármacosRESUMO
A study was made of acute experimental poisoning of lambs with A lusitanicus Lam. The animals suffered a nervous syndrome with physiopathologic changes in blood and cerebrospinal fluid indicative of nervous alterations. A lusitanicus Lam causes a form of "locoism" whose development may involve a thiamine deficiency.
Assuntos
Fabaceae/intoxicação , Doenças do Sistema Nervoso/veterinária , Plantas Medicinais , Doenças dos Ovinos/etiologia , Animais , Doenças do Sistema Nervoso/etiologia , Ovinos , Doenças dos Ovinos/sangue , Doenças dos Ovinos/líquido cefalorraquidiano , Doenças dos Ovinos/fisiopatologia , Tiamina/sangueRESUMO
A study was made of effect produced in lambs by the administration of Astragalus lusitanicus Lam at a daily dose of 1.25 g dry plant/kg live weight for 28 d. Clinical effects were not seen. No significant modifications were found in hematocrit, red or white blood cell count, differential leukocyte count, hemoglobin, methemoglobin, thiamine, lactate or pyruvate. Significant changes affected plasma LDH, GOT and CPK activity, where a progressive increase (70% for GOT and 113% for CPK) suggested changes in the CNS subsequently confirmed by histological examination (degeneration of neurons in the cerebrocortical grey matter, degeneration and loss of Purkinje cells in the cerebellum, satellitosis, neuronophagia, hyperemia and small hemorrhages throughout the CNS). Thiamine deficiency may play a role in this type of poisoning.