1.
Angew Chem Int Ed Engl
; 57(19): 5350-5354, 2018 05 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29493860
RESUMO
An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of α,γ-diamino acid derivatives with excellent stereoselectivity.