Detalhe da pesquisa
1.
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.
Nat Immunol
; 23(10): 1495-1506, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36151395
2.
In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma.
Immunity
; 54(3): 571-585.e6, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33497609
3.
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Nature
; 615(7950): 158-167, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634707
4.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Nature
; 622(7984): 850-862, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794185
5.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature
; 595(7866): 309-314, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953401
6.
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
Nature
; 565(7737): 43-48, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559380
7.
Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.
Hepatology
; 78(1): 225-242, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36862512
8.
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.
J Neuroinflammation
; 17(1): 296, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33036616
9.
Macrophage-Specific Hypoxia-Inducible Factor-1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis.
Hepatology
; 69(2): 545-563, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30102772
10.
Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.
Hepatology
; 69(3): 1105-1121, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30179264
11.
MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease.
Gastroenterology
; 154(1): 238-252.e7, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28987423
12.
Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90.
Hepatology
; 67(5): 1986-2000, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29251792
13.
Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use.
J Hepatol
; 69(5): 1145-1154, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30030149
14.
Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression.
J Neuroinflammation
; 15(1): 298, 2018 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30368255
15.
Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
J Biol Chem
; 291(52): 26794-26805, 2016 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810900
16.
Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease.
Hepatology
; 64(4): 1057-71, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27302565
17.
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice.
Liver Int
; 37(7): 968-973, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345165
18.
Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice.
Alcohol Clin Exp Res
; 40(7): 1524-30, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27177528
19.
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Proc Natl Acad Sci U S A
; 110(41): 16544-9, 2013 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24052526
20.
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
J Hepatol
; 63(5): 1147-55, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26100496