Detalhe da pesquisa
1.
A small-molecule degron with a phenylpropionic acid scaffold.
Bioorg Med Chem
; 109: 117789, 2024 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38870716
2.
Allosteric Hsp70 Modulator YM-1 Induces Degradation of BRD4.
Chem Pharm Bull (Tokyo)
; 72(2): 161-165, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296558
3.
Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling.
Int J Mol Sci
; 23(19)2022 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36232972
4.
Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen.
J Am Chem Soc
; 143(20): 7726-7731, 2021 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904715
5.
meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery.
Org Biomol Chem
; 19(2): 446-456, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33331380
6.
In vivo synthetic chemistry of proteolysis targeting chimeras (PROTACs).
Bioorg Med Chem
; 41: 116221, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34034148
7.
Functionalization of Human Serum Albumin by Tyrosine Click.
Int J Mol Sci
; 22(16)2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445381
8.
PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders.
Angew Chem Int Ed Engl
; 60(7): 3346-3354, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32410219
9.
Application of protein knockdown strategy targeting ß-sheet structure to multiple disease-associated polyglutamine proteins.
Bioorg Med Chem
; 28(1): 115175, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767406
10.
Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative.
Bioorg Med Chem Lett
; 28(4): 707-710, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29366651
11.
Structural development of tetrachlorophthalimides as liver X receptor ß (LXRß)-selective agonists with improved aqueous solubility.
Bioorg Med Chem Lett
; 28(4): 796-801, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29398545
12.
Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.
Int J Mol Sci
; 19(7)2018 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30021999
13.
Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.
Mol Pharmacol
; 91(3): 159-166, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27965304
14.
Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression.
Bioorg Med Chem Lett
; 27(12): 2776-2780, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28465099
15.
Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.
Bioorg Med Chem Lett
; 27(12): 2781-2787, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28465104
16.
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Bioorg Med Chem Lett
; 27(14): 3131-3134, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28539218
17.
Discovery of Small Molecules that Induce the Degradation of Huntingtin.
Angew Chem Int Ed Engl
; 56(38): 11530-11533, 2017 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28703441
18.
Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand.
Bioorg Med Chem
; 24(14): 3144-8, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27236416
19.
Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
Bioorg Med Chem
; 24(21): 5258-5269, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27591006
20.
Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Bioorg Med Chem
; 24(21): 5455-5461, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27622746