Assuntos
Doença de Charcot-Marie-Tooth/diagnóstico , Neurofibromatose 2/diagnóstico , Adulto , Diagnóstico Diferencial , Mutação da Fase de Leitura , Humanos , Imageamento por Ressonância Magnética , Masculino , Neurilemoma/cirurgia , Neurofibromatose 2/diagnóstico por imagem , Polineuropatias/complicações , Radiculopatia/diagnóstico por imagemAssuntos
Distonia/etiologia , Encefalite/complicações , Peptídeos e Proteínas de Sinalização Intracelular/imunologia , Convulsões/etiologia , Idoso , Anticorpos/sangue , Braço , Encefalite/diagnóstico por imagem , Face , Feminino , Humanos , Imageamento por Ressonância Magnética , Tomografia por Emissão de PósitronsRESUMO
OBJECTIVE: To describe different electroencephalogram (EEG) patterns and epileptic features in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE), their timeline in the course of the disease, their correlation with clinical data and outcome. METHODS: We retrospectively analyzed EEG recordings between November 2007 and June 2016 in 24 consecutive patients. RESULTS: Three EEG patterns were described: Excessive Beta Activity range 14-20â¯Hz (EBA) in 71% of patients, Extreme Delta Brush (EDB) in 58% and Generalized Rhythmic Delta Activity (GRDA) in 50%. They followed a chronological organization in the course of the disease: EBA appeared first, followed by EDB and then GRDA, as the median time of appearance for EBA, EDB and GRDA was respectively 10, 16.5 and 21.5â¯days. The presence of GRDA was strongly associated with concomitant abnormal movements (pâ¯<â¯0.001). CONCLUSION: This study focuses on EEG and epileptic abnormalities in anti-NMDARE. Beyond EDB that were already reported (Schmitt et al., 2012), GRDA seems to be a very frequent pattern. Its rhythmic aspect should not be misinterpreted as seizure or status epilepticus, to avoid antiepileptic treatments intensification. SIGNIFICANCE: This study comforts the importance of EEG in anti-NMDARE, with a better description of EEG abnormalities for a better treatment management.