Detalhe da pesquisa
1.
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes.
Nat Immunol
; 21(10): 1244-1255, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747817
2.
Safety and Efficacy of Novel Incretin Co-agonist Cotadutide in Biopsy-proven Noncirrhotic MASH With Fibrosis.
Clin Gastroenterol Hepatol
; 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38729399
3.
Dual glucagon-like peptide-1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity.
Diabetes Obes Metab
; 26(7): 2634-2644, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38562018
4.
Efficacy and safety of cotadutide, a dual glucagon-like peptide-1 and glucagon receptor agonist, in a randomized phase 2a study of patients with type 2 diabetes and chronic kidney disease.
Diabetes Obes Metab
; 24(7): 1360-1369, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35403793
5.
The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1.
J Proteome Res
; 20(9): 4507-4517, 2021 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34423991
6.
The role of pro-domains in human growth factors and cytokines.
Biochem Soc Trans
; 49(5): 1963-1973, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34495310
7.
Pharmacokinetics, safety, tolerability and efficacy of cotadutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, in phase 1 and 2 trials in overweight or obese participants of Asian descent with or without type 2 diabetes.
Diabetes Obes Metab
; 23(8): 1859-1867, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33908687
8.
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study.
Lancet
; 391(10140): 2607-2618, 2018 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945727
9.
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
J Immunol
; 198(1): 528-537, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881707
10.
Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.
J Biol Chem
; 292(5): 1925-1933, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994053
11.
MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study.
Br J Clin Pharmacol
; 84(10): 2325-2335, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29926478
12.
Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease.
Am J Physiol Renal Physiol
; 312(4): F748-F759, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27440778
13.
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Mol Cancer
; 14: 147, 2015 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-26227951
14.
Sustained peripheral depletion of amyloid-ß with a novel form of neprilysin does not affect central levels of amyloid-ß.
Brain
; 137(Pt 2): 553-64, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24259408
15.
Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
J Biol Chem
; 288(27): 19760-72, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23689510
16.
Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
J Immunol
; 199(5): 1943, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827388
17.
Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type.
Mol Cancer
; 12: 11, 2013 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23406016
18.
Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart.
Physiol Rep
; 11(6): e15597, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36946315
19.
Advances in antibody-based therapy in oncology.
Nat Cancer
; 4(2): 165-180, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36806801
20.
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture.
Nat Commun
; 14(1): 768, 2023 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36765057