RESUMO
The optimal neoadjuvant and adjuvant treatment for gastric cancer remains controversial. We conducted a phase II study using preoperative chemotherapy with modified FOLFOX6 followed by surgical resection and postoperative chemoradiation in patients with gastric carcinoma. Preoperative chemotherapy (two or three cycles) consisted of a 2-h infusion of oxaliplatin (100 mg/m2) and folinic acid (100 mg/m2) followed by a 46-h continuous infusion of 5-fluorouracil (5-FU; 2,400 mg/m2). Surgical resection was planned 4 weeks after the last chemotherapy cycle. Patients underwent postsurgical chemoradiation, receiving a total dose of 45 Gy and 5-FU continuous infusion (350 mg/m2/day). The primary end points were feasibility, overall response rate, and R0 resectability rate after preoperative chemotherapy. The secondary end points were tolerability, treatment-associated complications, disease-free survival, and overall survival. Nineteen patients were enrolled in this study. After neoadjuvant treatment, four patients (21.1%) experienced progressive disease, six patients (31.6%) showed partial remission, and nine patients (47.3%) showed stable disease. In 15 patients (78.9%) R0 resectability could be achieved. Eleven of these patients (73.3%) were able to undergo postoperative chemoradiation. Notably, eight (72.7%) of these patients were disease free and alive at median follow-up of 60 months. Chemotherapy associated neutropenia, neutropenic fever, and anastomotic dehiscence were observed. The combination of preoperative chemotherapy and postoperative chemoradiation is feasible in a significant subset of gastric cancer patients.
Assuntos
Adenocarcinoma/terapia , Quimiorradioterapia Adjuvante/métodos , Terapia Neoadjuvante/métodos , Neoplasias Gástricas/terapia , Adenocarcinoma/mortalidade , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica , Quimiorradioterapia Adjuvante/efeitos adversos , Procedimentos Cirúrgicos do Sistema Digestório , Intervalo Livre de Doença , Feminino , Fluoruracila , Humanos , Estimativa de Kaplan-Meier , Leucovorina , Masculino , Pessoa de Meia-Idade , Terapia Neoadjuvante/efeitos adversos , Compostos Organoplatínicos , Neoplasias Gástricas/mortalidadeRESUMO
In the title compound, C(12)H(10)ClN(2) (+)·I(-), the aromatic rings are oriented at a dihedral angle of 54.55â (3)°. In the crystal structure, inter-molecular C-Hâ¯I and C-Hâ¯Cl hydrogen bonds link the mol-ecules.
RESUMO
In the title compound, C(12)H(11)N(2) (+)·I(-), the aromatic rings are oriented at a dihedral angle of 73.40â (3)°. In the crystal structure, π-π contacts between the pyridine rings and the benzene and pyridine rings [centroid-centroid distances = 3.548â (3) and 4.211â (3)â Å] may stabilize the structure.
RESUMO
The asymmetric unit of the title compound, C(16)H(17)FN(2)O(4)S, contains three independent mol-ecules, in which the pyrimidine and benzene rings are oriented at dihedral angles of 41.72â (3)°, 26.21â (3)° and 36.49â (3)°. Intra-molecular C-Hâ¯O hydrogen bonds result in the formation of two six- and one seven-membered non-planar rings, which have have twist conformations. In the crystal structure, inter-molecular C-Hâ¯O hydrogen bonds link the mol-ecules.
RESUMO
In the title compound, C(11)H(17)N(3)O(6)·H(2)O, an important building block of the medicine cefbuperazone sodium, the piperazine ring adopts a screw-boat conformation. Inter-molecular O-Hâ¯O and intra-molecular N-Hâ¯O hydrogen bonds are observed. The water mol-ecule participates as both donor and acceptor in this framework.
RESUMO
The title compound, C(13)H(13)N(2) (+)·I(-), is a derivative of 1-amino-pyridinium iodide. The pyridine and benzene rings are oriented at a dihedral angle of 45.78â (3)°. In the crystal structure, weak inter-molecular C-Hâ¯I hydrogen bonds link the mol-ecules.