Detalhe da pesquisa
1.
Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models.
Br J Cancer
; 129(9): 1383-1388, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36765177
2.
Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra-individual heterogeneity in patients with advanced cancer.
Biometrics
; 79(4): 3752-3763, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37498050
3.
A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory.
Pharm Res
; 35(6): 122, 2018 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29675616
4.
Platform model describing pharmacokinetic properties of vc-MMAE antibody-drug conjugates.
J Pharmacokinet Pharmacodyn
; 44(6): 537-548, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28918591
5.
Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor.
Drugs R D
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700808
6.
Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure-Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor).
J Clin Pharmacol
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639108
7.
gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve.
CPT Pharmacometrics Syst Pharmacol
; 13(3): 341-358, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38082557
8.
Artificial Intelligence: From Buzzword to Useful Tool in Clinical Pharmacology.
Clin Pharmacol Ther
; 115(4): 698-709, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37881133
9.
Comparison of two-stage and joint TGI-OS modeling using data from six atezolizumab clinical studies in patients with metastatic non-small cell lung cancer.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 68-78, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37877248
10.
Deep-NCA: A deep learning methodology for performing noncompartmental analysis of pharmacokinetic data.
CPT Pharmacometrics Syst Pharmacol
; 13(5): 870-879, 2024 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38465417
11.
Tumor growth and overall survival modeling to support decision making in phase Ib/II trials: A comparison of the joint and two-stage approaches.
CPT Pharmacometrics Syst Pharmacol
; 13(6): 1017-1028, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629452
12.
Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics.
Clin Pharmacol Ther
; 115(3): 412-421, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069528
13.
Applications of Advanced Natural Language Processing for Clinical Pharmacology.
Clin Pharmacol Ther
; 115(4): 786-794, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38140747
14.
Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: bench to bedside investigation of pH-dependent solubility.
Mol Pharm
; 10(11): 4074-81, 2013 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099279
15.
A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer.
Biopharm Drug Dispos
; 34(3): 141-54, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23225350
16.
The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development.
Eur J Pharm Sci
; 182: 106380, 2023 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36638898
17.
Risk Factors of Hyperglycemia After Treatment With the AKT Inhibitor Ipatasertib in the Prostate Cancer Setting: A Machine Learning-Based Investigation.
JCO Clin Cancer Inform
; 7: e2200168, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116107
18.
A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score.
Clin Transl Sci
; 16(11): 2310-2322, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37718498
19.
Multistate Pharmacometric Model to Define the Impact of Second-Line Immunotherapies on the Survival Outcome of the IMpower131 Study.
Clin Pharmacol Ther
; 113(4): 851-858, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36606486
20.
Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR-SB.
CPT Pharmacometrics Syst Pharmacol
; 12(7): 1029-1042, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101394