Detalhe da pesquisa
1.
Progress in RAS-targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras.
Med Res Rev
; 44(2): 812-832, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38009264
2.
Targeting metabolism to enhance immunotherapy within tumor microenvironment.
Acta Pharmacol Sin
; 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38811773
3.
Crizotinib-based proteolysis targeting chimera suppresses gastric cancer by promoting MET degradation.
Cancer Sci
; 114(5): 1958-1971, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36692137
4.
Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer.
Small
; 19(18): e2207778, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36693784
5.
Neutrophils as potential therapeutic targets for breast cancer.
Pharmacol Res
; 198: 106996, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37972723
6.
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming.
Acta Pharmacol Sin
; 43(6): 1581-1593, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462561
7.
Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice.
Toxicol Appl Pharmacol
; 340: 58-66, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29294303
8.
Integrative Multi-Omics Analysis Identifies Transmembrane p24 Trafficking Protein 1 (TMED1) as a Potential Prognostic Marker in Colorectal Cancer.
Biology (Basel)
; 13(2)2024 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38392302
9.
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Adv Sci (Weinh)
; : e2308435, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38682467
10.
Dbl family RhoGEFs in cancer: different roles and targeting strategies.
Biochem Pharmacol
; 223: 116141, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38499108
11.
FXR agonist GW4064 enhances anti-PD-L1 immunotherapy in colorectal cancer.
Oncoimmunology
; 12(1): 2217024, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37261088
12.
Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy.
Eur J Med Chem
; 257: 115540, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37301075
13.
Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential.
Expert Opin Drug Discov
; 17(12): 1407-1423, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36503335
14.
Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer.
Theranostics
; 12(7): 3456-3473, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35547769
15.
Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer.
JCI Insight
; 7(22)2022 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36509291
16.
Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells.
Mol Ther Oncolytics
; 24: 340-354, 2022 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35118192
17.
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
J Med Chem
; 64(9): 5802-5815, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844923
18.
The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells.
Oxid Med Cell Longev
; 2021: 6677687, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34234887
19.
Enhanced anti-tumor efficacy by inhibiting HIF-1α to reprogram TAMs via core-satellite upconverting nanoparticles with curcumin mediated photodynamic therapy.
Biomater Sci
; 9(19): 6403-6415, 2021 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34259235
20.
Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/ß-catenin interaction.
Acta Pharm Sin B
; 11(11): 3481-3492, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34900531