Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

2023 Julius Axelrod Symposium: Plant-Derived Molecules Acting on G Protein-Coupled Receptors.

Labani, Nedjma; Gbahou, Florence; Lian, Shuangyu; Liu, Jianfeng; Jockers, Ralf.

Mol Pharmacol ; 105(5): 328-347, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38458772

2.

Melatonin receptor structure and signaling.

Okamoto, Hiroyuki H; Cecon, Erika; Nureki, Osamu; Rivara, Silvia; Jockers, Ralf.

J Pineal Res ; 76(3): e12952, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38587234

3.

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.

Cecon, Erika; Fernandois, Daniela; Renault, Nicolas; Coelho, Caio Fernando Ferreira; Wenzel, Jan; Bedart, Corentin; Izabelle, Charlotte; Gallet, Sarah; Le Poder, Sophie; Klonjkowski, Bernard; Schwaninger, Markus; Prevot, Vincent; Dam, Julie; Jockers, Ralf.

Cell Mol Life Sci ; 79(7): 361, 2022 Jun 13.

Artigo em Inglês | MEDLINE | ID: mdl-35697820

4.

Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat.

Helmi, Youssef Y; Papenkordt, Niklas; Rennar, Georg; Gbahou, Florence; El-Hady, Ahmed K; Labani, Nedjma; Schmidtkunz, Karin; Boettcher, Stefan; Jockers, Ralf; Abdel-Halim, Mohammad; Jung, Manfred; Zlotos, Darius P.

Arch Pharm (Weinheim) ; 356(9): e2300149, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37339785

5.

Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer's Disease.

Wang, Hoau-Yan; Cecon, Erika; Dam, Julie; Pei, Zhe; Jockers, Ralf; Burns, Lindsay H.

Int J Mol Sci ; 24(18)2023 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-37762230

6.

Genetic and biased agonist-mediated reductions in ß-arrestin recruitment prolong cAMP signaling at glucagon family receptors.

Jones, Ben; McGlone, Emma Rose; Fang, Zijian; Pickford, Phil; Corrêa, Ivan R; Oishi, Atsuro; Jockers, Ralf; Inoue, Asuka; Kumar, Sunil; Görlitz, Frederik; Dunsby, Chris; French, Paul M W; Rutter, Guy A; Tan, Tricia; Tomas, Alejandra; Bloom, Stephen R.

J Biol Chem ; 296: 100133, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33268378

7.

Pharmacological evidence for transactivation within melatonin MT₂ and serotonin 5-HT_2C receptor heteromers in mouse brain.

Gerbier, Romain; Ndiaye-Lobry, Delphine; Martinez de Morentin, Pablo B; Cecon, Erika; Heisler, Lora K; Delagrange, Philippe; Gbahou, Florence; Jockers, Ralf.

FASEB J ; 35(1): e21161, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33156577

8.

Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2.

Cecon, Erika; Izabelle, Charlotte; Poder, Sophie Le; Real, Fernando; Zhu, Aiwei; Tu, Ly; Ghigna, Maria Rosa; Klonjkowski, Bernard; Bomsel, Morgane; Jockers, Ralf; Dam, Julie.

J Pineal Res ; 72(1): e12772, 2022 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-34586649

9.

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development.

Chaves-Almagro, Carline; Auriau, Johanna; Dortignac, Alizée; Clerc, Pascal; Lulka, Hubert; Deleruyelle, Simon; Projetti, Fabrice; Nakhlé, Jessica; Frances, Audrey; Berta, Judit; Gigoux, Véronique; Fourmy, Daniel; Dufresne, Marlène; Gomez-Brouchet, Anne; Guillermet-Guibert, Julie; Cordelier, Pierre; Knibiehler, Bernard; Jockers, Ralf; Valet, Philippe; Audigier, Yves; Masri, Bernard.

Int J Mol Sci ; 23(18)2022 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-36142542

10.

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking.

Lucey, Maria; Ashik, Tanyel; Marzook, Amaara; Wang, Yifan; Goulding, Joëlle; Oishi, Atsuro; Broichhagen, Johannes; Hodson, David J; Minnion, James; Elani, Yuval; Jockers, Ralf; Briddon, Stephen J; Bloom, Stephen R; Tomas, Alejandra; Jones, Ben.

Mol Pharmacol ; 100(4): 319-334, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34315812

11.

Amyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor.

Cecon, Erika; Lhomme, Tori; Maurice, Tangui; Luka, Marine; Chen, Min; Silva, Anisia; Wauman, Joris; Zabeau, Lennart; Tavernier, Jan; Prévot, Vincent; Dam, Julie; Jockers, Ralf.

Neuroendocrinology ; 111(4): 370-387, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-32335558

12.

Melatonin controversies, an update.

Boutin, Jean A; Jockers, Ralf.

J Pineal Res ; 70(2): e12702, 2021 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-33108677

13.

Journal of pineal research guideline for authors: Defining and characterizing melatonin targets.

Cecon, Erika; Legros, Céline; Boutin, Jean A; Jockers, Ralf.

J Pineal Res ; 70(2): e12712, 2021 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-33332653

14.

Melatonin promotes regeneration of injured motor axons via MT₁ receptors.

Stazi, Marco; Negro, Samuele; Megighian, Aram; D'Este, Giorgia; Solimena, Michele; Jockers, Ralf; Lista, Florigio; Montecucco, Cesare; Rigoni, Michela.

J Pineal Res ; 70(1): e12695, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-32939783

15.

GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.

Ahmad, Raise; Lahuna, Olivier; Sidibe, Anissa; Daulat, Avais; Zhang, Qiang; Luka, Marine; Guillaume, Jean-Luc; Gallet, Sarah; Guillonneau, François; Hamroune, Juliette; Polo, Sophie; Prévot, Vincent; Delagrange, Philippe; Dam, Julie; Jockers, Ralf.

Cell Mol Life Sci ; 77(24): 5189-5205, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-31900622

16.

Melatonin MT₁ and MT₂ receptor ERK signaling is differentially dependent on G_i/o and G_q/11 proteins.

Chen, Min; Cecon, Erika; Karamitri, Angeliki; Gao, Wenwen; Gerbier, Romain; Ahmad, Raise; Jockers, Ralf.

J Pineal Res ; 68(4): e12641, 2020 May.

Artigo em Inglês | MEDLINE | ID: mdl-32080899

17.

A novel leptin receptor antagonist uncouples leptin's metabolic and immune functions.

Zabeau, Lennart; Wauman, Joris; Dam, Julie; Van Lint, Sandra; Burg, Elianne; De Geest, Jennifer; Rogge, Elke; Silva, Anisia; Jockers, Ralf; Tavernier, Jan.

Cell Mol Life Sci ; 76(6): 1201-1214, 2019 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-30659329

18.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Suofu, Yalikun; Li, Wei; Jean-Alphonse, Frédéric G; Jia, Jiaoying; Khattar, Nicolas K; Li, Jiatong; Baranov, Sergei V; Leronni, Daniela; Mihalik, Amanda C; He, Yanqing; Cecon, Erika; Wehbi, Vanessa L; Kim, JinHo; Heath, Brianna E; Baranova, Oxana V; Wang, Xiaomin; Gable, Matthew J; Kretz, Eric S; Di Benedetto, Giulietta; Lezon, Timothy R; Ferrando, Lisa M; Larkin, Timothy M; Sullivan, Mara; Yablonska, Svitlana; Wang, Jingjing; Minnigh, M Beth; Guillaumet, Gérald; Suzenet, Franck; Richardson, R Mark; Poloyac, Samuel M; Stolz, Donna B; Jockers, Ralf; Witt-Enderby, Paula A; Carlisle, Diane L; Vilardaga, Jean-Pierre; Friedlander, Robert M.

Proc Natl Acad Sci U S A ; 114(38): E7997-E8006, 2017 09 19.

Artigo em Inglês | MEDLINE | ID: mdl-28874589

19.

Retraction Note: Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin.

Hill, Steven M; Cheng, Chi; Yuan, Lin; Mao, Lulu; Jockers, Ralf; Dauchy, Bob; Frasch, Tripp; Blask, David E.

Breast Cancer Res Treat ; 206(1): 211, 2024 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-38607596

20.

Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic Functions.

Roujeau, Clara; Jockers, Ralf; Dam, Julie.

Neuroendocrinology ; 108(2): 132-141, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30326479

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