Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Transgenic ferret models define pulmonary ionocyte diversity and function.

Yuan, Feng; Gasser, Grace N; Lemire, Evan; Montoro, Daniel T; Jagadeesh, Karthik; Zhang, Yan; Duan, Yifan; Ievlev, Vitaly; Wells, Kristen L; Rotti, Pavana G; Shahin, Weam; Winter, Michael; Rosen, Bradley H; Evans, Idil; Cai, Qian; Yu, Miao; Walsh, Susan A; Acevedo, Michael R; Pandya, Darpan N; Akurathi, Vamsidhar; Dick, David W; Wadas, Thaddeus J; Joo, Nam Soo; Wine, Jeffrey J; Birket, Susan; Fernandez, Courtney M; Leung, Hui Min; Tearney, Guillermo J; Verkman, Alan S; Haggie, Peter M; Scott, Kathleen; Bartels, Douglas; Meyerholz, David K; Rowe, Steven M; Liu, Xiaoming; Yan, Ziying; Haber, Adam L; Sun, Xingshen; Engelhardt, John F.

Nature ; 621(7980): 857-867, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37730992

2.

Notch signaling inactivation by small molecule Î³-secretase inhibitors restores the multiciliated cell population in the airway epithelium.

Vladar, Eszter K; Kunimoto, Koshi; Rojas-Hernandez, Laura S; Spano, Jacquelyn M; Sellers, Zachary M; Joo, Nam Soo; Cooney, Riley A; Axelrod, Jeffrey D; Milla, Carlos E.

Am J Physiol Lung Cell Mol Physiol ; 324(6): L771-L782, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-37039381

3.

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance.

Evans, T Idil Apak; Joo, Nam Soo; Keiser, Nicholas W; Yan, Ziying; Tyler, Scott R; Xie, Weiliang; Zhang, Yulong; Hsiao, Jordy J; Cho, Hyung-Ju; Wright, Michael E; Wine, Jeffrey J; Engelhardt, John F.

Am J Respir Cell Mol Biol ; 54(4): 469-81, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26334941

4.

Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea.

Jeong, Jin Hyeok; Joo, Nam Soo; Hwang, Peter H; Wine, Jeffrey J.

Am J Physiol Lung Cell Mol Physiol ; 307(1): L83-93, 2014 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24793168

5.

Critical role of down-regulated in adenoma bicarbonate transporter in linaclotide stimulated intestinal bicarbonate secretion.

Sarthi, Jessica B; Trumbull, Annie M; Abazari, Shayda M; van Unen, Vincent; Chan, Joshua E; Joo, Nam Soo; Jiang, Yanfen; Kuo, Calvin J; Sellers, Zachary M.

bioRxiv ; 2023 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-37205513

6.

Variation in CFTR-dependent 'ß-sweating' among healthy adults.

DeRose, Lesje; Kim, Jeeyeon; Farahmand, Miesha; Shinbashi, Meagan Y; Joo, Nam Soo; Wine, Jeffrey J.

PLoS One ; 17(3): e0265432, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35312728

7.

Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands.

Khansaheb, Monal; Choi, Jae Young; Joo, Nam Soo; Yang, Yu-Mi; Krouse, Mauri; Wine, Jeffrey J.

Am J Physiol Lung Cell Mol Physiol ; 300(3): L370-9, 2011 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-21131402

8.

Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model.

Joo, Nam Soo; Cho, Hyung-Ju; Shinbashi, Meagan; Choi, Jae Young; Milla, Carlos E; Engelhardt, John F; Wine, Jeffrey J.

Sci Rep ; 11(1): 18828, 2021 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-34552115

9.

Mucus secretion from individual submucosal glands of the ferret trachea.

Cho, Hyung-Ju; Joo, Nam Soo; Wine, Jeffrey J.

Am J Physiol Lung Cell Mol Physiol ; 299(1): L124-36, 2010 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-20435689

10.

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis.

Choi, Jae Young; Joo, Nam Soo; Krouse, Mauri E; Wu, Jin V; Robbins, Robert C; Ianowski, Juan P; Hanrahan, John W; Wine, Jeffrey J.

J Clin Invest ; 117(10): 3118-27, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17853942

11.

Progress in understanding mucus abnormalities in cystic fibrosis airways.

Wine, Jeffrey J; Hansson, Gunnar C; König, Peter; Joo, Nam Soo; Ermund, Anna; Pieper, Mario.

J Cyst Fibros ; 17(2S): S35-S39, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-28951068

12.

Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.

Sellers, Zachary M; Illek, Beate; Figueira, Miriam Frankenthal; Hari, Gopika; Joo, Nam Soo; Sibley, Eric; Souza-Menezes, Jackson; Morales, Marcelo M; Fischer, Horst; Wine, Jeffrey J.

PLoS One ; 12(12): e0189894, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-29281691

13.

Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel.

Joo, Nam Soo; Jeong, Jin Hyeok; Cho, Hyung-Ju; Wine, Jeffrey J.

Sci Rep ; 6: 36806, 2016 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-27830759

14.

Inhibition of airway surface fluid absorption by cholinergic stimulation.

Joo, Nam Soo; Krouse, Mauri E; Choi, Jae Young; Cho, Hyung-Ju; Wine, Jeffrey J.

Sci Rep ; 6: 20735, 2016 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-26846701

15.

Secretion rates of human nasal submucosal glands from patients with chronic rhinosinusitis or cystic fibrosis.

Jeong, Jin Hyeok; Hwang, Peter H; Cho, Do-Yeon; Joo, Nam Soo; Wine, Jeffrey J.

Am J Rhinol Allergy ; 29(5): 334-8, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26358343

16.

Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins.

Joo, Nam Soo; Evans, Idil Apak T; Cho, Hyung-Ju; Park, Il-Ho; Engelhardt, John F; Wine, Jeffrey J.

PLoS One ; 10(2): e0116756, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25706550

17.

Quest for cystic fibrosis pharmacotherapy.

Joo, Nam Soo.

Clin Exp Pharmacol Physiol ; 35(8): 861-2, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18714439

18.

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.

Wine, Jeffrey J; Char, Jessica E; Chen, Jonathan; Cho, Hyung-Ju; Dunn, Colleen; Frisbee, Eric; Joo, Nam Soo; Milla, Carlos; Modlin, Sara E; Park, Il-Ho; Thomas, Ewart A C; Tran, Kim V; Verma, Rohan; Wolfe, Marlene H.

PLoS One ; 8(10): e77114, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24204751

19.

Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs.

Cho, Hyung-Ju; Joo, Nam Soo; Wine, Jeffrey J.

PLoS One ; 6(8): e24424, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21935358

20.

Measurement of fluid secretion from intact airway submucosal glands.

Wine, Jeffrey J; Joo, Nam Soo; Choi, Jae Young; Cho, Hyung-Ju; Krouse, Mauri E; Wu, Jin V; Khansaheb, Monal; Irokawa, Toshiya; Ianowski, Juan; Hanrahan, John W; Cuthbert, Alan W; Tran, Kim V.

Methods Mol Biol ; 742: 93-112, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21547728

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