Detalhe da pesquisa
1.
A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.
Pharm Res
; 41(4): 651-672, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38519817
2.
A cross-industry forum on benchmarking critical quality attribute identification and linkage to process characterization studies.
Biologicals
; 67: 9-20, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32665104
3.
Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation.
Pharm Res
; 34(12): 2817-2828, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29110285
4.
Structural Characterization of a Monoclonal Antibody-Maytansinoid Immunoconjugate.
Anal Chem
; 88(1): 695-702, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26629796
5.
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses.
J Biol Chem
; 287(30): 25266-79, 2012 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22584577
6.
Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation.
Sci Adv
; 9(25): eade7890, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37352349
7.
Classification and characterization of therapeutic antibody aggregates.
J Biol Chem
; 286(28): 25118-33, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454532
8.
Chemical modifications in therapeutic protein aggregates generated under different stress conditions.
J Biol Chem
; 286(28): 25134-44, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518762
9.
Observation of Heavy-Chain C-Terminal Amidation in Human Endogenous IgG.
J Pharm Sci
; 111(9): 2445-2450, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718127
10.
Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities.
J Pharm Sci
; 111(4): 1012-1023, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35139332
11.
State-of-the-art and emerging trends in analytical approaches to pharmaceutical-product commercialization.
Curr Opin Biotechnol
; 78: 102800, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36182871
12.
A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins.
J Pharm Sci
; 111(6): 1556-1564, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35167884
13.
A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization.
Biochemistry
; 49(28): 5880-90, 2010 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20527993
14.
Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.
Biochemistry
; 49(44): 9667-76, 2010 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20857926
15.
Characterization of Subvisible Particles in Biotherapeutic Prefilled Syringes: The Role of Polysorbate and Protein on the Formation of Silicone Oil and Protein Subvisible Particles After Drop Shock.
J Pharm Sci
; 109(1): 640-645, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31689431
16.
Glycan engineering reveals interrelated effects of terminal galactose and core fucose on antibody-dependent cell-mediated cytotoxicity.
Biotechnol Prog
; 36(6): e3045, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32627435
17.
Silicone Oil Particles in Prefilled Syringes With Human Monoclonal Antibody, Representative of Real-World Drug Products, Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems.
J Pharm Sci
; 109(1): 845-853, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628922
18.
Determination of interactions between antibody biotherapeutics and copper by size exclusion chromatography (SEC) coupled with inductively coupled plasma mass spectrometry (ICP/MS).
Anal Chim Acta
; 1079: 252-259, 2019 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31387718
19.
Impact of Precipitation of Antibody Therapeutics After Subcutaneous Injection on Pharmacokinetics and Immunogenicity.
J Pharm Sci
; 108(6): 1953-1963, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30684540
20.
Evaluating Immunogenicity Risk Due to Host Cell Protein Impurities in Antibody-Based Biotherapeutics.
AAPS J
; 18(6): 1439-1452, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27450229