Detalhe da pesquisa
1.
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
EMBO Rep
; 22(5): e51851, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932076
2.
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Nature
; 541(7635): 87-91, 2017 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002403
3.
A coordinated DNA damage response promotes adult quiescent neural stem cell activation.
PLoS Biol
; 15(5): e2001264, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28489848
4.
PARP-3 and APLF function together to accelerate nonhomologous end-joining.
Mol Cell
; 41(1): 33-45, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21211721
5.
Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
Cereb Cortex
; 27(1): 11-23, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28365778
6.
Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.
J Cell Sci
; 128(19): 3597-606, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303202
7.
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS Genet
; 9(3): e1003226, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23505375
8.
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
Nucleic Acids Res
; 40(17): 8371-80, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22740648
9.
Requirement for DNA ligase IV during embryonic neuronal development.
J Neurosci
; 31(27): 10088-100, 2011 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21734301
10.
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.
EMBO J
; 26(22): 4720-31, 2007 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914460
11.
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.
DNA Repair (Amst)
; 8(6): 760-6, 2009 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19303373
12.
Distinct response of adult neural stem cells to low versus high dose ionising radiation.
DNA Repair (Amst)
; 76: 70-75, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30822688
13.
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.
DNA Repair (Amst)
; 3(11): 1493-502, 2004 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380105
14.
Anticancer drug resistance of HeLa cells transfected with rat glutathione S-transferase pi gene.
Biomed Environ Sci
; 16(2): 157-62, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12964789
15.
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
DNA Repair (Amst)
; 12(5): 356-66, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23518413
16.
T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice.
J Biol Chem
; 280(9): 7452-9, 2005 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15613485