Detalhe da pesquisa
1.
PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Proc Natl Acad Sci U S A
; 114(15): 3891-3896, 2017 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28348215
2.
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction.
J Am Chem Soc
; 140(6): 2151-2164, 2018 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29381352
3.
Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.
Med Res Rev
; 35(2): 286-305, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25145640
4.
Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).
J Am Chem Soc
; 137(7): 2628-40, 2015 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25616005
5.
Two continuous coupled assays for ornithine-δ-aminotransferase.
Anal Biochem
; 440(2): 145-9, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23747282
6.
Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.
Bioorg Med Chem
; 21(4): 903-11, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23306054
7.
Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands.
ACS Chem Neurosci
; 4(1): 96-109, 2013 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23336049
8.
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.
Eur J Med Chem
; 48: 97-107, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22204903
9.
Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7ß-, 8α-, and 8ß-methyl substituted dihydrexidine analogues.
J Med Chem
; 54(15): 5508-21, 2011 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21714510
10.
Mapping the catechol binding site in dopamine D1 receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues.
ChemMedChem
; 6(6): 1024-40, 2011 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538900