Detalhe da pesquisa
1.
Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy.
JAMA
; 330(15): 1448-1458, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37768671
2.
Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis.
N Engl J Med
; 379(1): 22-31, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29972757
3.
mNIS+7 and lower limb function in inotersen treatment of hereditary transthyretin-mediated amyloidosis.
Muscle Nerve
; 62(4): 502-508, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32654212
4.
Neuropathy symptom and change: Inotersen treatment of hereditary transthyretin amyloidosis.
Muscle Nerve
; 62(4): 509-515, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32654156
5.
Characteristics of Patients with Hereditary Transthyretin Amyloidosis-Polyneuropathy (ATTRv-PN) in NEURO-TTRansform, an Open-label Phase 3 Study of Eplontersen.
Neurol Ther
; 12(1): 267-287, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525140
6.
Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD.
Kidney Int Rep
; 7(2): 200-209, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35155859
7.
PK/PD modeling of FXI antisense oligonucleotides to bridge the dose-FXI activity relation from healthy volunteers to end-stage renal disease patients.
CPT Pharmacometrics Syst Pharmacol
; 10(8): 890-901, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34085768
8.
Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data.
ESC Heart Fail
; 8(1): 652-661, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33283485
9.
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy.
Neurol Ther
; 10(1): 375-389, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33638113
10.
Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy.
Diabetes Care
; 42(4): 585-593, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30765435
11.
Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes.
Diabetes Care
; 41(4): 807-814, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439147
12.
Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial.
Amyloid
; 25(3): 180-188, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30169969