Detalhe da pesquisa
1.
C-Terminal Decarboxylation of Proline-Derived Building Blocks for Protein-Binding Peptides.
Chemistry
; : e202401678, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38770931
2.
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc Natl Acad Sci U S A
; 117(47): 29684-29690, 2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33184177
3.
Synthetic α-Helical Peptides as Potential Inhibitors of the ACE2 SARS-CoV-2 Interaction.
Chembiochem
; 23(17): e202200372, 2022 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35785462
4.
Design and synthesis of a tetracyclic tripeptide mimetic frozen in a polyproline type II (PP2) helix conformation.
Org Biomol Chem
; 20(47): 9368-9377, 2022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385673
5.
Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics.
Chemistry
; 26(14): 3049-3053, 2020 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31961029
6.
Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules.
Angew Chem Int Ed Engl
; 59(14): 5747-5755, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31944532
7.
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc Natl Acad Sci U S A
; 112(16): 5011-6, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25848013
8.
Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.
Chemistry
; 21(23): 8464-70, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25906737
9.
Intramolecular bridges formed by photoswitchable click amino acids.
Beilstein J Org Chem
; 8: 884-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015838
10.
Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration.
Front Cell Dev Biol
; 10: 1008898, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36274843
11.
Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation.
Chemistry
; 17(43): 12037-44, 2011 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21901773
12.
Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.
Bioorg Med Chem
; 18(21): 7365-79, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932767
13.
Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept.
Mol Divers
; 14(2): 401-8, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19685275
14.
Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.
Angew Chem Int Ed Engl
; 48(27): 5042-5, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19472239
15.
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.
J Med Chem
; 62(22): 10321-10341, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31670515
16.
Efficient α-helix induction in a linear peptide chain by N-capping with a bridged-tricyclic diproline analogue.
Angew Chem Int Ed Engl
; 52(36): 9539-43, 2013 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23873809
17.
Solution-state (15)N NMR spectroscopic study of alpha-C-phycocyanin: implications for the structure of the chromophore-binding pocket of the cyanobacterial phytochrome Cph1.
Chembiochem
; 8(18): 2249-55, 2007 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17973280
18.
The oxidized subunit B8 from human complex I adopts a thioredoxin fold.
Structure
; 12(9): 1645-54, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341729
19.
Recognition of proline-rich motifs by protein-protein-interaction domains.
Angew Chem Int Ed Engl
; 44(19): 2852-69, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15880548
20.
Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.
Angew Chem Int Ed Engl
; 49(39): 7111-5, 2010 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20803590