Detalhe da pesquisa
1.
Master transcription factors and mediator establish super-enhancers at key cell identity genes.
Cell
; 153(2): 307-19, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23582322
2.
DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma.
Gynecol Oncol
; 172: 82-91, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001446
3.
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01.
Liver Int
; 43(1): 208-220, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35924447
4.
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.
Genes Dev
; 23(21): 2484-9, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19884255
5.
Mediator and cohesin connect gene expression and chromatin architecture.
Nature
; 467(7314): 430-5, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20720539
6.
A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC).
Prostate Cancer Prostatic Dis
; 2024 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38341461
7.
mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment.
Mol Cancer Res
; 19(4): 717-725, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33443105
8.
Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers.
Mol Cancer Ther
; 20(11): 2240-2249, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482288
9.
Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors.
Sci Rep
; 11(1): 9920, 2021 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972574
10.
Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer.
Clin Cancer Res
; 26(23): 6158-6167, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32878766
11.
Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer.
JCO Precis Oncol
; 42020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33015525
12.
Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.
Br J Pharmacol
; 174(24): 4637-4650, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574171
13.
The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development.
Dev Cell
; 21(3): 575-88, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21852201
14.
A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity.
PLoS One
; 5(1): e8794, 2010 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20098713
15.
Inhibition of CtBP1 activity by Akt-mediated phosphorylation.
J Mol Biol
; 398(5): 657-71, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20361981
16.
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.
Genes Dev
; 22(6): 746-55, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18347094
17.
Multiple activities contribute to Pc2 E3 function.
EMBO J
; 24(1): 108-19, 2005 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15592428
18.
The polycomb protein Pc2 is a SUMO E3.
Cell
; 113(1): 127-37, 2003 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12679040