RESUMO
Basic phenomena of the "macroscopic fluctuations are repeated on the light beams generated by lasers or light-emitting diodes. Study of the light beams fluctuations look promissory.
Assuntos
Lasers , Luz , Modelos Teóricos , Óptica e Fotônica/métodosRESUMO
A non-invasive method for the study of platelet aggregation and formation of leukocyte-erythrocyte-platelet aggregates as well as certain hemostatic parameters is proposed. The method is based on the speckle-analysis of coherent light scattering from the surface of erythrocytes moving in an artificially isolated vessel segment. It was shown that light scattering index significantly correlated with ADP-, adrenalin-, or collagen-induced platelet aggregation, with the formation of leukocyte-erythrocyte or platelet-erythrocyte aggregates, and with the levels of fibrinogen, soluble fibrin-monomer complexes and related parameters. It is concluded that the proposed method for the study of hemostatic system can be used to roughly evaluate intensity of intravascular blood coagulation and probability of thrombosis.
Assuntos
Plaquetas/metabolismo , Agregação Eritrocítica/fisiologia , Eritrócitos/metabolismo , Hemostasia/fisiologia , Leucócitos/metabolismo , Agregação Plaquetária/fisiologia , Trombose/diagnóstico , Adolescente , Adulto , Idoso , Análise Química do Sangue/métodos , Coagulação Sanguínea , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Trombose/sangue , Adulto JovemRESUMO
Available data on the effect of various trace elements on iodine metabolism and function of thyroid gland (TG) were systematized in this article. Subsequently, promising possibilities of herbal therapy in treatment and prevention of TG diseases were considered. Systemic analyis of the results of 3 independent open-label clinical studies performed in accordance with requirements of evidence-based medicine that involved herbal medicinal product Alba® (root extract of white cinquefoil) was carried out. Therapeutic options of Alba® use in various TG pathologies were presented.
Assuntos
Fitoterapia , Preparações de Plantas/uso terapêutico , Potentilla/química , Doenças da Glândula Tireoide/tratamento farmacológico , Humanos , Preparações de Plantas/administração & dosagem , Preparações de Plantas/isolamento & purificação , Ensaios Clínicos Controlados Aleatórios como Assunto , Doenças da Glândula Tireoide/etiologia , Doenças da Glândula Tireoide/metabolismo , Doenças da Glândula Tireoide/prevenção & controle , Hormônios Tireóideos/metabolismo , Resultado do TratamentoRESUMO
The article considers the noninvasive technique of analysis of aggregation activity of thrombocytes and formation of leukocytic-erythrocytic-thrombocytic aggregates and some particular indicators of hemostasis system. The speckle-analysis of characteristics of coherent light dispersion from surface of erythrocytes moving in artificially isolated vessel section. The study established high correlation ratio between light dispersion index and spontaneous ADP-, adrenalin- and collagen-induced aggregation of thrombocytes, formation of leukocytic-erythrocytic and thrombocytic-erythrocytic aggregations. The established facts permits to consider that analysis noninvasive technique makes it possible to estimate approximately the aggregation activity of blood corpuscles.
Assuntos
Plaquetas , Agregação Celular/efeitos dos fármacos , Eritrócitos , Leucócitos , Difosfato de Adenosina/farmacologia , Plaquetas/citologia , Plaquetas/efeitos dos fármacos , Colágeno/farmacologia , Epinefrina/farmacologia , Eritrócitos/citologia , Eritrócitos/efeitos dos fármacos , Hemostasia/fisiologia , Humanos , Leucócitos/citologia , Leucócitos/efeitos dos fármacosRESUMO
We have conducted a study on a large group of healthy and sick subjects and have demonstrated that a new index of coagulativety (SKF), based on measurement of the laser speckle signal from the finger root, correlates with chronological age ranging from 1 to 85 years old. The kinds of non-invasive measurements were obtained during two measurement sessions: one with the application of over-systolic occlusion and another without application of the occlusion. The very significant correlation with age was noted both during the stasis stage and during the non-occluding stage. We observed a higher SKF index in sick subjects, correlating directly with severity of illness. We speculated that the observed phenomena are caused by temporarily fluctuations in local blood viscosity associated with interactions of the Red Blood Cells and endothelial cells.
Assuntos
Envelhecimento/fisiologia , Velocidade do Fluxo Sanguíneo/fisiologia , Viscosidade Sanguínea/fisiologia , Técnicas de Diagnóstico Cardiovascular , Humanos , Valores de Referência , Índice de Gravidade de DoençaRESUMO
High prevalence of hyperplastic and autoimmune diseases of thyroid in Ukrainian population is determined by endemic deficit of iodine and selenium. The aim of this research was to assess the place of biologically-active additions on the basis of herbal material containing an iodine and selenium in prophylaxis and treatment of thyroid pathology. During the six month period 55 patients received herbal preparation Alba twice a day. The levels of TSH, volume of thyroid, the sizes of nodular goiter (ultrasound investigation) were measured before and at the end of the investigation. The levels of thyroid stimulating antibodies to TSH receptor (AB-r TSH) were evaluated in patients with hyperthyroidism. The results of Alba application showed that in patients with thyroid pathology (diffuse nontoxic goiter, hyperthyroidism and chronic thyroiditis) it was possible to reduce the volume of thyroid, normalize its function, and decrease the level of AB-r TSH in diffuse toxic goiter. We also found approximately 20 % shortening of the time needed to get target level of TSH and finally the duration of treatment of thyrotoxicosis.