RESUMO
An 80-year-old woman with essential cryoglobulinemia developed recurrent, widespread, purpuric lesions with superficial skin ulcers and cold urticaria. No disorders of other organ systems were recognized. Attempts to transfer the cold sensitivity passively by serum and isolated cryoprecipitate of the patient were successful. Immunochemical studies showed that the cryoglobulin was composed of IgG only. It was suggested that the cryoprecipitate might not be due to immune complex formation in this case.
Assuntos
Crioglobulinas/análise , Hipergamaglobulinemia/complicações , Imunoglobulina G/análise , Urticária/etiologia , Corticosteroides/uso terapêutico , Idoso , Temperatura Baixa/efeitos adversos , Feminino , Humanos , Imunização Passiva , Pessoa de Meia-Idade , Púrpura/etiologia , Urticária/tratamento farmacológico , Urticária/imunologiaRESUMO
Mitogen-induced blastoid transformation of peripheral blood lymphocytes from patients with myasthenia gravis was studied using a microplate culture technique and evaluated with 3H-thymidine incorporation. It was found that both phytohaemagglutinin and pokeweed mitogen responses decreased significantly in patients with myasthenia gravis. In myasthenic crisis, indices of stimulation by phytohaemagglutination became very low. The autologous plasma neither inhibited nor facilitated mitogenic responses of lymphocytes. The decreased mitogen responsiveness of lymphocytes suggests that part of the T lymphocyte function is subnormal in myasthenia.