[Protective properties of IgM in experiments on animals]. / Izuchenie zashchitnykh svoistv IgM v éksperimente na zhivotnykh

On a model of intraperitoneal infection of albino mice the authors demonstrated a protective action of the fraction enriched with IgM and of gamma-globulin isolated from the normal human blood serum, against E. coli O111. The intensity of the protective action depended on the method, duration of administration of the preparation and also on the infective dose. Protective properties of the fraction enriched with IgM were more pronounced in comparison with the gamma-globulin preparation.

[Comparative study of the antibody concentration and protective activity against Pseudomonas aeruginosa of gamma-globulin and IgM-enriched immunoglobulin preparations]. / Sravnitel'noe izuchenie kontsentratsii antitel i protektivnoi aktivnosti k Pseudomonas aeruginosa preparatov gamma-globulina i immunoglobulina, obogashchennogo IgM.

The protective effect of IgM-enriched immunoglobulin isolated by the caprylate-alcohol technique has been found to be more pronounced in comparison with that of the commercial preparation of gamma globulin in experiments on mice infected with P. aeruginosa live culture. The effectiveness of this protective action correlates with a higher content of antibodies to P. aeruginosa O-antigen in IgM-enriched immunoglobulin. In mice injected with P. aeruginosa toxin both preparations have shown equal intensity of their protective action.