Detalhe da pesquisa
1.
Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Mol Cancer Ther
; 22(2): 254-263, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36722141
2.
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.
Mol Cancer Ther
; 21(9): 1439-1448, 2022 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35793464
3.
Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography - high resolution mass spectrometry.
J Pharm Biomed Anal
; 205: 114287, 2021 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34385015
4.
Potentiation of PBD Dimers by Lipophilicity Manipulation.
Curr Top Med Chem
; 19(9): 741-752, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30931859
5.
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual ß-glucuronide and dipeptide triggers.
Eur J Med Chem
; 179: 591-607, 2019 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31279293
6.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
J Med Chem
; 60(23): 9490-9507, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29112410
7.
Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.
Chem Commun (Camb)
; (14): 1688-9, 2003 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12877504
8.
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
J Med Chem
; 53(7): 2927-41, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218628