Detalhe da pesquisa
1.
Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
PLoS Pathog
; 16(8): e1008716, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32780760
2.
Repurposing N-hydroxy thienopyrimidine-2,4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: Synthesis and biological characterization.
Bioorg Chem
; 129: 106198, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36265353
3.
The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.
J Biol Chem
; 293(21): 7969-7981, 2018 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29626094
4.
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
Bioorg Med Chem Lett
; 29(2): 257-261, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30522956
5.
Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage.
J Virol
; 91(3)2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881652
6.
Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.
Hepatology
; 59(2): 408-22, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24022996
7.
Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV).
Acta Pharm Sin B
; 12(4): 1671-1684, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35847513
8.
Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
DNA Repair (Amst)
; 85: 102747, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31775111
9.
Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.
Eur J Med Chem
; 204: 112626, 2020 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32814250
10.
Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules.
Viruses
; 12(4)2020 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32316297
11.
Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.
Elife
; 92020 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33169665
12.
Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
J Med Chem
; 62(9): 4669-4682, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30998359
13.
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.
Eur J Med Chem
; 166: 390-399, 2019 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30739822
14.
5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.
Eur J Med Chem
; 164: 179-192, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30594676
15.
Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
ChemMedChem
; 13(16): 1658-1663, 2018 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29968426
16.
New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
Eur J Pharm Sci
; 118: 67-79, 2018 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29574079
17.
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
Eur J Med Chem
; 156: 652-665, 2018 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031976
18.
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.
Eur J Med Chem
; 156: 680-691, 2018 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031978
19.
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
Eur J Med Chem
; 141: 149-161, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29031062
20.
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
J Med Chem
; 60(12): 5045-5056, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28525279