Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Ion channel auxiliary subunit: does one size fit all?

Karbat, Izhar; Reuveny, Eitan.

Cell ; 184(2): 299-301, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33482096

2.

Voltage Sensing Comes to Rest.

Karbat, Izhar; Reuveny, Eitan.

Cell ; 178(4): 776-778, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31398335

3.

Pore-modulating toxins exploit inherent slow inactivation to block K⁺ channels.

Karbat, Izhar; Altman-Gueta, Hagit; Fine, Shachar; Szanto, Tibor; Hamer-Rogotner, Shelly; Dym, Orly; Frolow, Felix; Gordon, Dalia; Panyi, Gyorgy; Gurevitz, Michael; Reuveny, Eitan.

Proc Natl Acad Sci U S A ; 116(37): 18700-18709, 2019 09 10.

Artigo em Inglês | MEDLINE | ID: mdl-31444298

4.

Reduced activity of GIRK1-containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory.

Mett, Alice; Karbat, Izhar; Tsoory, Michael; Fine, Shachar; Iwanir, Shachar; Reuveny, Eitan.

J Physiol ; 599(2): 521-545, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33124684

5.

Deletion of PsbM in tobacco alters the Q_B site properties and the electron flow within photosystem II.

Umate, Pavan; Schwenkert, Serena; Karbat, Izhar; Bosco, Cristina Dal; Mlcòchová, Lada; Volz, Stefanie; Zer, Hagit; Herrmann, Reinhold G; Ohad, Itzhak; Meurer, Jörg.

J Biol Chem ; 293(29): 11649, 2018 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-30030384

6.

One-shot design elevates functional expression levels of a voltage-gated potassium channel.

Weinstein, Jonathan Jacob; Saikia, Chandamita; Karbat, Izhar; Goldenzweig, Adi; Reuveny, Eitan; Fleishman, Sarel Jacob.

Protein Sci ; 33(6): e4995, 2024 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-38747377

7.

Mapping the interaction site for a ß-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels.

Zhang, Joel Z; Yarov-Yarovoy, Vladimir; Scheuer, Todd; Karbat, Izhar; Cohen, Lior; Gordon, Dalia; Gurevitz, Michael; Catterall, William A.

J Biol Chem ; 287(36): 30719-28, 2012 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-22761417

8.

Understanding the Molecular Regulation of Serotonin Receptor 5-HTR_1B-ß-Arrestin1 Complex in Stress and Anxiety Disorders.

Dutta Gupta, Oindrilla; Karbat, Izhar; Pal, Kuntal.

J Mol Neurosci ; 73(7-8): 664-677, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37580644

9.

Store-operated Ca²⁺ entry regulatory factor alters murine metabolic state in an age-dependent manner via hypothalamic pathways.

Gataulin, Diana; Kuperman, Yael; Tsoory, Michael; Biton, Inbal E; Nataniel, Tomer; Palty, Raz; Karbat, Izhar; Meshcheriakova, Anna; Reuveny, Eitan.

PNAS Nexus ; 2(3): pgad068, 2023 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-37007714

10.

Structure-function map of the receptor site for ß-scorpion toxins in domain II of voltage-gated sodium channels.

Zhang, Joel Z; Yarov-Yarovoy, Vladimir; Scheuer, Todd; Karbat, Izhar; Cohen, Lior; Gordon, Dalia; Gurevitz, Michael; Catterall, William A.

J Biol Chem ; 286(38): 33641-51, 2011 Sep 23.

Artigo em Inglês | MEDLINE | ID: mdl-21795675

11.

Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.

Gur, Maya; Kahn, Roy; Karbat, Izhar; Regev, Noa; Wang, Jinti; Catterall, William A; Gordon, Dalia; Gurevitz, Michael.

J Biol Chem ; 286(40): 35209-17, 2011 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-21832067

12.

Modern venomics-Current insights, novel methods, and future perspectives in biological and applied animal venom research.

von Reumont, Bjoern M; Anderluh, Gregor; Antunes, Agostinho; Ayvazyan, Naira; Beis, Dimitris; Caliskan, Figen; Crnkovic, Ana; Damm, Maik; Dutertre, Sebastien; Ellgaard, Lars; Gajski, Goran; German, Hannah; Halassy, Beata; Hempel, Benjamin-Florian; Hucho, Tim; Igci, Nasit; Ikonomopoulou, Maria P; Karbat, Izhar; Klapa, Maria I; Koludarov, Ivan; Kool, Jeroen; Lüddecke, Tim; Ben Mansour, Riadh; Vittoria Modica, Maria; Moran, Yehu; Nalbantsoy, Ayse; Ibáñez, María Eugenia Pachón; Panagiotopoulos, Alexios; Reuveny, Eitan; Céspedes, Javier Sánchez; Sombke, Andy; Surm, Joachim M; Undheim, Eivind A B; Verdes, Aida; Zancolli, Giulia.

Gigascience ; 112022 05 18.

Artigo em Inglês | MEDLINE | ID: mdl-35640874

13.

Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels.

Karbat, Izhar; Ilan, Nitza; Zhang, Joel Z; Cohen, Lior; Kahn, Roy; Benveniste, Morris; Scheuer, Todd; Catterall, William A; Gordon, Dalia; Gurevitz, Michael.

J Biol Chem ; 285(40): 30531-8, 2010 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-20682774

14.

Production of recombinant venom peptides as tools for ion channel research.

Saikia, Chandamita; Ben-Nissan, Gili; Reuveny, Eitan; Karbat, Izhar.

Methods Enzymol ; 654: 169-201, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34120712

15.

Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.

Szanto, Tibor G; Gaal, Szabolcs; Karbat, Izhar; Varga, Zoltan; Reuveny, Eitan; Panyi, Gyorgy.

J Gen Physiol ; 153(6)2021 06 07.

Artigo em Inglês | MEDLINE | ID: mdl-34014250

16.

A Molecular Lid Mechanism of K⁺ Channel Blocker Action Revealed by a Cone Peptide.

Saikia, Chandamita; Dym, Orly; Altman-Gueta, Hagit; Gordon, Dalia; Reuveny, Eitan; Karbat, Izhar.

J Mol Biol ; 433(17): 166957, 2021 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-33771569

17.

Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins.

Kahn, Roy; Karbat, Izhar; Ilan, Nitza; Cohen, Lior; Sokolov, Stanislav; Catterall, William A; Gordon, Dalia; Gurevitz, Michael.

J Biol Chem ; 284(31): 20684-91, 2009 Jul 31.

Artigo em Inglês | MEDLINE | ID: mdl-19509294

18.

Non-sedating antihistamines block G-protein-gated inwardly rectifying K⁺ channels.

Chen, I-Shan; Liu, Chang; Tateyama, Michihiro; Karbat, Izhar; Uesugi, Motonari; Reuveny, Eitan; Kubo, Yoshihiro.

Br J Pharmacol ; 176(17): 3161-3179, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31116876

19.

SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped ß-Sandwich Fold Important for SOCE Modulation.

Kimberlin, Christopher R; Meshcheriakova, Anna; Palty, Raz; Raveh, Adi; Karbat, Izhar; Reuveny, Eitan; Minor, Daniel L.

J Mol Biol ; 431(15): 2869-2883, 2019 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-31082439

20.

X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity.

Karbat, Izhar; Turkov, Michael; Cohen, Lior; Kahn, Roy; Gordon, Dalia; Gurevitz, Michael; Frolow, Felix.

J Mol Biol ; 366(2): 586-601, 2007 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-17166514

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