[Nucleoprotein complexes of yeast and their biological effect on T-lymphocytes]. / Nukleoproteinovye kompleksy drozhzhei i ikh biologicheskaia aktivnost' po otnosheniiu k T-limfotsitam.

Complexes of nucleic acids and acid nuclear proteins that are active toward human T-lymphocytes were isolated from cells of bakers' yeast Saccharomyces cerevisiae. The conditions of isolation of nucleoprotein complexes by acid extraction followed by microfiltration for concentration of macromolecular components were optimized. Gel filtration and electrophoresis were used to study the composition and molecular weights of components of the preparations obtained. It was shown that nucleoprotein complex had a molecular weight of 1430 kDa. However, only one zone was determined by electrophoresis of the protein component with a molecular weight of 30 kDa.

[Our experience with acycloguanosine treatment of herpes simplex]. / Opyt lecheniia prostogo gerpesa atsikloguanozinom.

A 5% ointment acycloguanosine was tried in the treatment of recurrent herpes simplex of the skin and genitalia in 48 patients. The treatment brought limitation of the process, relief of the symptoms, control of local manifestations and toxicity, accelerated epithelization, complete regression and disappearance of the eruption.

[The reactions of the upper respiratory pathways to low doses of ionizing radiation]. / Reaktsii verkhnikh dykhatel'nykh putei na malye dozy ioniziruiushchego izlucheniia.

The state of upper respiratory tract, non-specific cell resistance and immune status were studied in persons who participated in liquidation of the Chernobyl APS disaster consequences. The prolonged influence of factors caused by small doses of ionizing irradiation leads to mucosa affection of upper respiratory tract, considerable reduction of phagocytic and antiviral activity of monocytes and worsening of the immune status of organism. The data obtained during researches explains the considerable increase of ARD among these persons.

[Intravascular photohemotherapy in the complex prophylaxis of purulent-septic complications after coronary shunting]. / Vnutrisosudistaia fotogemoterapiia v kompleksnoi profilaktike gnoino-septicheskikh oslozhnenii posle koronarnogo shuntirovaniia.

The article presents results of treatment of 78 patients with the history of coronary bypass operations for ischemic heart disease. There were 48 patients with high risk factors of the development of pyo-septic complications. Among them there were 27 patients treated by complex postoperative therapy including intravascular photomodification of blood. The intravascular irradiation of blood was shown to have a positive influence upon the development of the early postoperative period in this category of patients. The immunomodulating effect was noted due to a greater amount of activated lymphocytes and T-helpers in blood. The positive dynamics of immunological indices were in correspondence with the data of the clinical state, pyo-inflammatory complications were not registered in this group of patients. Early (on the 3rd-5th days) inclusion of the intravascular irradiation of blood in the complex postoperative therapy is thought to be expedient for the patients with high risk of pyo-inflammatory complications.