Detalhe da pesquisa
1.
Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.
Cell
; 172(5): 952-965.e18, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474921
2.
Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain.
J Biol Chem
; 299(9): 105100, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37507019
3.
Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1.
RNA
; 28(7): 927-936, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35459748
4.
Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.
Biochemistry
; 61(24): 2933-2939, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36484984
5.
Substrate analogs that trap the 2'-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2'-phosphotransferase) reaction pathway.
RNA
; 26(4): 373-381, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932322
6.
Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference.
Nucleic Acids Res
; 48(9): 4643-4657, 2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32282904
7.
Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers.
Org Biomol Chem
; 17(35): 8083-8087, 2019 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31460550
8.
Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1.
Proc Natl Acad Sci U S A
; 113(51): 14727-14732, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27930312
9.
Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA.
Beilstein J Org Chem
; 15: 79-88, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30680042
10.
2'ß-Fluoro-Tricyclo Nucleic Acids (2'F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNaseâ H Activation.
Chemistry
; 23(43): 10310-10318, 2017 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28477335
11.
A homolog of lariat-debranching enzyme modulates turnover of branched RNA.
RNA
; 20(8): 1337-48, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24919400
12.
Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1.
Nucleic Acids Res
; 42(16): 10845-55, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25123664
13.
Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme.
J Org Chem
; 80(20): 10108-18, 2015 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378468
14.
Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates.
J Org Chem
; 79(3): 963-75, 2014 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24401015
15.
Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake.
Nucleic Acid Ther
; 33(4): 265-276, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37196168
16.
Small Molecule-Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids.
Adv Sci (Weinh)
; 10(12): e2205713, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36752390
17.
The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.
Res Sq
; 2023 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398028
18.
Design and enhanced gene silencing activity of spherical 2'-fluoroarabinose nucleic acids (FANA-SNAs).
Chem Sci
; 12(8): 2993-3003, 2021 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164068
19.
Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA).
Org Biomol Chem
; 7(9): 1904-10, 2009 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19590787
20.
Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.
ACS Chem Biol
; 12(3): 622-627, 2017 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28055181