Detalhe da pesquisa
1.
Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Bioorg Med Chem
; 100: 117588, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38295487
2.
Analysis of the immunostimulatory effects of cytokine-expressing internal ribosome entry site-based RNA adjuvants and their applications.
J Infect Dis
; 2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37711050
3.
mRNA-HPV vaccine encoding E6 and E7 improves therapeutic potential for HPV-mediated cancers via subcutaneous immunization.
J Med Virol
; 95(12): e29309, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38100632
4.
Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII.
J Enzyme Inhib Med Chem
; 38(1): 2154603, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36728712
5.
Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant.
J Enzyme Inhib Med Chem
; 38(1): 2228515, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470410
6.
Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity.
J Enzyme Inhib Med Chem
; 38(1): 2189097, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36927348
7.
Discovery of New Quinolone-Based Diarylamides as Potent B-RAFV600E/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity.
Int J Mol Sci
; 24(4)2023 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36834628
8.
Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole-Pyrimidine Derivatives as Potential Antiproliferative Agents.
Medicina (Kaunas)
; 59(6)2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37374282
9.
Structure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives.
Bioorg Med Chem Lett
; 31: 127662, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33227415
10.
Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90.
Int J Mol Sci
; 21(24)2020 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33317068
11.
Nanoformulated Single-Stranded RNA-Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen-Presenting Cells.
Angew Chem Int Ed Engl
; 59(28): 11540-11549, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239636
12.
Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
Bioorg Med Chem
; 26(21): 5596-5611, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30385226
13.
Structural and biochemical characterization of FabK from Thermotoga maritima.
Biochem Biophys Res Commun
; 482(4): 968-974, 2017 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908729
14.
Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.
Bioorg Med Chem Lett
; 27(2): 237-241, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914802
15.
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
Bioorg Med Chem
; 25(17): 4677-4685, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28720324
16.
Coordinative Amphiphiles as Tunable siRNA Transporters.
Bioconjug Chem
; 27(8): 1850-6, 2016 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27364494
17.
Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening.
Bioorg Med Chem Lett
; 26(14): 3307-3312, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27241691
18.
ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles.
Bioorg Med Chem Lett
; 25(10): 2162-8, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25881828
19.
Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists.
Bioorg Med Chem Lett
; 25(7): 1546-51, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25765911
20.
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Bioorg Med Chem Lett
; 25(6): 1324-8, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25677662