A review of recent developments in kenaf fiber/polylactic acid composites research.

Kenaf fiber has recently garnered exponential interest as reinforcement in composite materials across diverse industries owing to its superior mechanical attributes, ease of manufacture, and inherent biodegradability. In the discourse of this review, various methods of manufacturing kenaf/Polylactic acid (PLA) composites have been discussed meticulously, as delineated in recently published scientific literatures. This paper delves into the chemical modification of kenaf fiber, examining its consequential impact on tensile strength and thermal stability of the kenaf/PLA composites. Further, this review illuminates the role of innovative 3D printing techniques and fiber orientation in augmenting the mechanical robustness of the kenaf/PLA composites. Simultaneously, recent insightful explorations into the acoustic properties of the kenaf/PLA composites, underscoring their potential as sustainable alternative to conventional materials have been reviewed. Serving as a comprehensive repository of knowledge, this review paper holds immense value for researchers aiming to utilize the capabilities of kenaf fiber reinforced PLA composites.

Unique Aberrations in Intimal Sarcoma Identified by Next-Generation Sequencing as Potential Therapy Targets.

Intimal sarcomas are rare and histologically heterogeneous tumors, commonly arising from the pulmonary arteries. They have remained challenging to treat. Few studies in the literature study the genomics of this cancer. Identifying targetable alterations is an important step in advancing the treatment of intimal sarcomas. Using data from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (AACR GENIE) database, we cataloged genetic alterations and assessed their clinical utility from thirteen patients with intimal sarcoma. Notable copy number alterations included amplification in MDM2, CDK4, PDGFRA, and NOTCH2, as well as copy number losses in CDKN2A and CDKN2B. Actionable alterations included mutations in ATM/ATR, PTCH1, and PDGFRB. Moreover, genomic rearrangement events, specifically PDE4DIP-NOTCH2 and MRPS30-ARID2 fusions were identified. Co-occurring alterations included a NOTCH2 copy number gain in the PDE4DIP-NOTCH2 fusion positive tumor and PDGFRB mutations in both fusion-positive cases. Our study suggests that PDGFRB may be relevant in the tumorigenesis process. Including genomic profiling in the management of intimal sarcoma and potential enrollment in targeted therapy trials is warranted.