Diaphragmatic parameters by ultrasonography for predicting weaning outcomes.

BACKGROUND: Diaphragmatic dysfunction remains the main cause of weaning difficulty or failure. Ultrasonographic measurement of diaphragmatic function can be used to predict the outcomes of weaning from mechanical ventilation. Our primary objective was to investigate the performance of various sonographic parameters of diaphragmatic function for predicting the success of weaning from mechanical ventilation. METHODS: We prospectively enrolled 68 adult patients requiring mechanical ventilation who were admitted to the intensive care unit from June 2013 to November 2013. The diaphragmatic inspiratory excursion, time to peak inspiratory amplitude of the diaphragm (TPIAdia), diaphragmatic thickness (DT), DT difference (DTD), and diaphragm thickening fraction (TFdi) were determined by bedside ultrasonography performed at the end of a spontaneous breathing trial. A receiver operating characteristic curve was used for analysis. RESULTS: In total, 62 patients were analyzed. The mean TPIAdia was significantly higher in the weaning success group (right, 1.27 ± 0.38 s; left, 1.14 ± 0.37 s) than in the weaning failure group (right, 0.97 ± 0.43 s; left, 0.85 ± 0.39 s) (P <  0.05). The sensitivity, specificity, positive predictive value, and negative predictive value of a TPIAdia of > 0.8 s in predicting weaning success were 92, 46, 89, and 56%, respectively. The diaphragmatic inspiratory excursion, DTD, and TFdi were associated with reintubation within 48 h. The P values were 0.047, 0.021, and 0.028, and the areas under the receiver operating characteristic curve were 0.716, 0.805, and 0.784, respectively. CONCLUSION: Among diaphragmatic parameters, TPIAdia exhibits good performance in predicting the success of weaning from mechanical ventilation. This study demonstrated a trend toward successful use of TPIAdia rather than diaphragmatic inspiratory excursion as a predictor of weaning from mechanical ventilation.

Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia.

BACKGROUND AND OBJECTIVE: Triple combination therapy with tiotropium plus budesonide/formoterol has improved lung function and reduced exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) in Western countries, but no such data exist for East Asian patients. This study aimed to evaluate the efficacy and tolerability of adding budesonide/formoterol to tiotropium compared with tiotropium alone in East Asian patients with severe/very severe COPD. METHODS: This 12-week, randomized, parallel-group, multicentre, open-label study was conducted in East Asia. After a 14-day run-in period during which patients received tiotropium 18 µg once daily, patients were randomized to tiotropium (18 µg once daily) + budesonide/formoterol (160/4.5 µg 2 inhalations twice daily) or tiotropium alone (18 µg once daily). The primary endpoint was change from baseline in pre-dose forced expiratory volume in 1 s (FEV1 ) to the mean of values measured at Weeks 1, 6 and 12. RESULTS: Pre-dose FEV1 significantly increased from baseline with tiotropium plus budesonide/formoterol (n = 287) versus tiotropium alone (n = 291) (5.0% vs 0.6%; treatment difference: 4.4% (95% CI: 1.9-6.9), P = 0.0004). Triple therapy also reduced the COPD exacerbation rate by 40.7% (P = 0.0032) and prolonged time to first exacerbation (38.6% risk reduction, P = 0.0167) versus tiotropium alone and markedly improved health-related quality of life (HRQoL), measured using the St George's Respiratory Questionnaire. Incidence of adverse events was 26% for both groups. CONCLUSIONS: In East Asian patients with severe/very severe COPD, adding budesonide/formoterol to tiotropium was associated with significant improvements in FEV1 and HRQoL and lower COPD exacerbation rates. Treatment was generally well tolerated. CLINICAL TRIAL REGISTRATION: NCT01397890 at Clinicaltrials.gov.

Validation of the new COPD assessment test translated into Thai in patients with chronic obstructive pulmonary disease.

BACKGROUND: The COPD Assessment Test (CAT™) is a new questionnaire that has been developed recently for measuring the COPD patient's health status. It is known to have a good correlation with disease specific health status measured by St. George's Respiratory Questionnaire (SGRQ). For the wider application in clinical practice, it has been validated in many countries. We evaluated the reliability and validity of the translated CAT questionnaire for Thai COPD patients. METHODS: The study was designed as a cross-sectional validation study enrolling stable Thai COPD patients from three academic centers in Thailand at a single visit. The original CAT questionnaire was translated to Thai through linguistic validation process. The official Thai CAT and SGRQ questionnaires were filled by Thai patients after orientation by the out-patient nurse. The reliability of all items was assessed by Cronbach's formula for coefficient using pooled data from all patients. The validity of the questionnaire was tested using Pearson's correlation with SGRQ. RESULTS: A total of 98 Thai COPD patients completed the official Thai CAT questionnaire; 83% were male, mean age 71 years (SD 8.2), and % predicted of FEV1 56.6% (SD 20.9). The official Thai CAT questionnaire was shown to have a high internal consistency (Cronbach's α coefficient = 0.853). The assessment of validity of official Thai CAT questionnaire was moderately correlated with that of SGRQ (r = 0.652). CONCLUSIONS: The official Thai CAT questionnaire has an acceptable reliability and validity. It can be expected to serve as a short and simple tool for assessment of the health status of Thai COPD patients.

Transthoracic ultrasound assessment of B-lines for identifying the increment of extravascular lung water in shock patients requiring fluid resuscitation.

INTRODUCTION: Several studies have shown that the number of B-lines was related to the amount of extravascular lung water (EVLW). In our study, we aimed to demonstrate the magnitude of the incremental B-lines in shock patients with positive net fluid balance and the association with gas exchange impairment. MATERIALS AND METHODS: We performed trans-thoracic ultrasound at admission (T0) and at follow-up period (TFL) to demonstrate the change of B lines (ΔB-lines) after fluid therapy. We compared the total B-line score (TBS) at T0 and TFL and calculated the Pearson's correlation coefficient between the ΔB-lines and PaO2/FiO2 ratio. RESULTS: A total of 20 patients were analyzed. All patients had septic shock. Net fluid balance was + 2228.05 ± 1982.15 ml. The TBS at T0 and TFL were 36.6 ± 23.73 and 63.80 ± 29.25 (P < 0.01). The ΔB-lines along anterior axillary line (AAL) correlated to the ΔTBS (r = 0.90, P < 0.01). The ΔB-lines along AAL had inverse correlation to PaO2/FiO2 ratio (r = -0.704, P < 0.05). The increase of B-lines ≥ 10 was related to the decrease of PaO2/FiO2 ratio. The inter-observer reliability between two ultrasound readers was high (r = 0.92, P < 0.01). DISCUSSION: The number of B-lines increased in shock patients with positive net fluid balance and correlated to impaired oxygenation. These data supported the benefit of ultrasound for assessing the EVLW.

Association between admission delay and adverse outcome of emergency medical patients.

AIM: To determine whether admission delay (lead-time) and other factors are associated with hospital mortality rates of emergency medical patients. METHODS: Patients presenting with emergency conditions during August to November 2009, and admitted to medical wards, including intensive care units, were enrolled. The time each patient spent in the ED, and other parameters were recorded. The primary outcome was the association between lead-time and hospital mortality. The secondary outcome was the association between lead-time and delta Modified Early Warning Score (MEWS) (MEWS at ward - MEWS at ED). RESULTS: 381 cases were analysed. The overall mortality rate was 8.9%. By univariate analysis, the significant factors associated with mortality outcome were lead-time, ECOG (Eastern Cooperative Oncology Group) score, MEWS at ED, delta MEWS and sepsis. By multivariate analysis, the remaining significant factors were MEWS at ED, delta MEWS and sepsis. There was no significant relationship between delta MEWS and lead-time. In a sub-group of patients admitted to intensive care units, however, there was a positive correlation between lead-time and delta MEWS. CONCLUSION: MEWS, delta MEWS and sepsis were predictors of hospital mortality in emergency medical patients. Lead-time was not associated with mortality, which could be due to benefits of various treatments initiated in the ED. In patients requiring intensive care, however, the longer lead-time probably led to higher MEWS and mortality.

Identifying non-tuberculous mycobacterium lung diseases in acid-fast bacilli positive patients.

We conducted a case-control study by comparing the clinical and radiographic features of acid-fast bacilli positive patients with pulmonary tuberculosis (PTB) to those with non-tuberculous mycobacterium (NTM) lung diseases diagnosed according to American Thoracic Society (ATS) criteria. The occurrence of NTM lung disease was associated with persistence in symptoms after the fifth month of treatment (p=0.018), middle lobe involvement (p<0.01), lower lobe involvement (p=0.004), multiple lobe involvement (p=0.001) and reticulo-nodular infiltration (p=0.041). On logistic regression analysis, persistence of symptoms after 5 months of treatment (p<0.001), middle lobe involvement (p<0.001) and lower lobe involvement (p<0.05) were significant predictors of NTM lung disease.These findings suggest physicians should consider NTM lung disease if there is involvement of the middle lobe or lower lobes on chest radiography or the persistence of symptoms at the fifth month of treatment.

Validation of Ramathibodi's acute asthma predictive score.

BACKGROUND: The authors have recently developed Ramathibodi's acute asthma predictive score to help the attending physician decide on a safe discharge of an acute asthmatic patient from the emergency room (ER). However the authors did not validate it in the previous study. OBJECTIVE: To validate the predictive score with a new different population. MATERIAL AND METHOD: The authors conducted a study on acute asthmatic patients, in continuation from our previous study, between September 2005 and September 2007 in the ER of Ramathibodi Hospital. Vital signs, oxygen saturation, and severity factors were recorded. All patients were treated with nebulized salbutamol initially and repeatedly if the peak expiratory flow rates were < 70% predicted or if unfavorable physical signs were seen. The patients who had any of the severity factors were given systemic steroids. Patients were assessed for admission if further treatments were needed after the fourth nebulization. An unfavorable outcome was defined as either hospital admission or relapse within 48 hours of the ER discharge. Then, the authors' predictive score was calculated to give a total score for each patient. Using a cutoff score of 2, the authors calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). The area under the receiver operating characteristic (ROC) curve (AUC) was also calculated and compared with that of the development cohort. RESULTS: There were 863 visits from 546 patients and 66.6% had a score of < or = 1 while 33.4% had a score of > or = 2. Using a cutoff score of 2, the acute asthma score exhibited a sensitivity of 60.0%, a specificity of 67.4%, a PPV of 5.7%, and a NPV of 98.1%. The validation group's AUC did not differ from that of the development group. CONCLUSION: Ramathibodi's acute asthma predictive score was found as a valid useful tool for a proper ER discharge of acute asthmatic patients.

Percutaneous dilatational tracheostomy with bronchoscopic guidance: Ramathibodi experience.

BACKGROUND: Tracheostomy is considered as the airway management of choice for patients in the ICU who require prolonged mechanical ventilation or airway protection. Percutaneous dilational tracheostomy (PDT) was first described in 1985 and now is a well-established procedure that can be performed at the bedside by a pulmonologist with less surgical equipment required. DESIGN: A retrospective analysis. MATERIAL AND METHOD: Twelve patients underwent PDT because of prolonged endotracheal intubation between March and December 2006. The procedures were done by using bedside percutaneous dilatation tracheostomy with guidewire dilator forceps (GWDF) technique with bronchoscopic guidance under general anesthesia in either the intensive care unit or the intermediate care unit of Department of Medicine, Ramathibodi Hospital. RESULTS: There were seven men and five women with a mean age of 55.0 +/- 11.8 years. Operative mortality was 0%. Procedure related complication was not found Operation time in each case was less than ten minutes. Bronchoscopic examination performed in one of the cases after one month of tracheostomy tube removed showed no scar at the tracheostomy site. CONCLUSION: PDT with bronchoscopic guidance is a safe and easy procedure that can be done by pulmonologist at the bedside setting.

A predictive score for unfavorable outcome of acute asthma in the emergency room.

BACKGROUND: It is sometimes difficult to decide on a safe discharge of an acute asthmatic patient from the emergency room (ER). OBJECTIVE: To develop a predictive score for safe discharge of an acute asthmatic patient from the ER. MATERIAL AND METHOD: All adult asthmatic patients who visited the ER at Ramathibodi Hospital from January 2004 to August 2005 were recruited Vital signs, oxygen saturation, and severity factors were recorded. Salbutamol was nebulized initially and repeatedly if the peak expiratory flow rates (PEFR) were < 70% predicted or if unfavorable physical signs were seen. Systemic steroids were administered to those patients whose severity factors had been identified Patients were admitted if further treatments were needed after the 4th nebulization. An unfavorable outcome was defined as either hospital admission or relapse within 48 hours of the ER discharge. Univariate analysis of each variable was performed, followed by multivariate analysis of those with statistical significance. Predictive scores were derived from statistically significant factors at the cutoff point of receiver-operating curve that yielded the best area under the curve. RESULTS: There were 905 visits from 568 patients. Predictive factors included inability to lie down on presentation and wheezing or low PEFR after the last dose of bronchodilator. A comparison of score sensitivity, specificity, and predictive values, across different cutoffs indicated that a score of 2 predicted an unfavorable outcome. CONCLUSION: A predictive score based on three bedside parameters might be used for a safe discharge of asthma patients from the ER.

Lactate and combined parameters for triaging sepsis patients into intensive care facilities.

PURPOSE: To find predictors of intensive care unit (ICU) requirement within the first 48 hours in newly diagnosed sepsis patients presenting at the emergency department. MATERIALS AND METHODS: Analysis of a prospective observational cohort was performed. We recruited new sepsis patients at the emergency department, and collected baseline characteristics and parameters. Variables were compared between patients: those that required ICU within 48 hours and those that did not. Multivariate analysis was performed to identify independent predictors. RESULTS: Out of 719 patients enrolled, 275 were confirmed to have sepsis. There were 107 patients (39%) that required ICU admission within 48 hours. Independent predictors for ICU requirement were: lower body temperature (P = .019), initial lactate (P = .02), 2-hour lactate clearance (P = .035), and the Sequential Organ Failure Assessment (SOFA) score without cardiovascular component (SOFA no CVS) (P < .001). The optimal cutoff values for the two strongest predictors were: SOFA no CVS ≥5 (adjusted OR, 5.3; 95% CI, 1.9-14.7) and initial lactate ≥1.9 mmol/L (adjusted OR, 3.3; 95% CI, 1.2-8.9). We also proposed a combined "LACTIC score" with higher predictive ability. CONCLUSIONS: We suggested a way to predict ICU requirement in sepsis patients and proposed a combined score that might be better than individual parameters. Further validation should be performed before using them clinically.

Expiratory air trapping during asthma exacerbation: Relationships with clinical indices and proximal airway morphology.

OBJECTIVES: To semi-quantitatively assess expiratory air trapping (AT(exp)) and structural changes in the proximal airways in asthma during asthma exacerbation (AE) and to explore the relationships among AT(exp), clinical indices, and proximal airway changes. METHODS: Paired inspiratory-dynamic forced expiratory CT scans of 36 asthmatics (30 women, 6 men; mean age, 49.2±18.9 years) performed during AE were retrospectively reviewed for the total AT(exp) score (summed scores [extent grading (0-4)×pattern grading (1-4)] of the twelve lung zones), morphologic parameters and expiratory bronchial collapse (BC(exp)) of the proximal airways. The relationships of the score with clinical indices and proximal airway morphology (normalized by body surface area [BSA]) were analyzed. A p value of <0.05 was considered statistically significant. RESULTS: The mean total AT(exp) score was 110.1±43.4 (range, 8-166). It was higher in the lower zones and in patients older than 60 years, having BMI of <27.5 kg/m(2), and peak expiratory flow rate (PEFR) of <60% predicted. Correlation existed between the score and age (r=0.331), BMI (r=-0.375), BSA (r=-0.442), % predicted PEFR (r=-0.332), right upper lobe apical segmental bronchus (RB1)-wall area (WA)/BSA (r=0.467), %RB1-WA (r=0.395), and RB1-bronchial wall thickness (BWT)/BSA (r=0.378). The score showed no correlation with BC(exp) and other morphologic bronchial parameters. Area under receiver-operating-characteristic curve 0.724 (95% CI) showed that the score of 110 could discriminate patients with PEFR of <60% predicted from those with PEFR of ≥60% predicted. CONCLUSION: During AE, there was a high prevalence of extensive AT(exp) which was correlated with patient's age, BMI, BSA, AE severity and RB1 morphology but not correlated with BC(exp).

Predicting laryngeal edema in intubated patients by portable intensive care unit ultrasound.

PURPOSE: The purpose of this study is to determine the diagnostic accuracy of portable ultrasound for detection of laryngeal edema (LE) in intubated patients. MATERIALS AND METHODS: We conducted a prospective, observational study from December 2010 to September 2011. We measured air column width differences (ACWD) in planned extubation patients admitted in intensive care unit by ultrasound. The primary outcome was the diagnostic accuracy of ACWD to predict the presence of LE. RESULTS: A total of 101 patients were enrolled. The prevalence of LE was 16.8%. Baseline characteristics were similar between intubated patients with and without LE. The mean difference of increasing of air column width in patients without LE was higher than in LE group (1.9 vs 1.08 mm, P<.001). The sensitivity and specificity at ACWD higher or equal to 1.6 mm were 0.706 and 0.702, respectively. The positive predictive value and negative predictive value were 0.324 and 0.922, respectively. The area under the receiver operating characteristic curve of laryngeal ultrasound was 0.823 (95% confidence interval, 0.698-0.947) and that of cuff leak test was 0.840 (95% confidence interval, 0.715-0.964). CONCLUSION: Portable intensive care unit ultrasound visualizing ACWD between predeflation and postdeflation cuff balloon is a promising objective tool, which aids in prediction of successful extubation regarding LE.

Acute respiratory failure due to Pneumocystis pneumonia: outcome and prognostic factors.

OBJECTIVES: To examine the outcome and prognostic factors of in-hospital mortality in patients with acute respiratory failure (ARF) caused by Pneumocystis pneumonia (PCP) admitted to a medical intensive care unit. METHODS: A retrospective review was conducted of all patients with ARF from PCP in Ramathibodi Hospital between 2000 and 2006. Patient characteristics, clinical presentation, and laboratory, radiological and microbiological findings, as well as therapy and clinical course were included in the analysis of prognostic factors of death. RESULTS: A total of 14 HIV-infected and 30 otherwise immunosuppressed patients were identified. The overall mortality rate was 63.6%. Logistic regression analysis demonstrated that APACHE II score on day 1 and level of PEEP used on day 3 of respiratory failure were associated with higher hospital mortality. In a comparison between the HIV group and the non-HIV group, the early mortality rate was significantly higher in the HIV group, but late hospital mortality was not different between the two groups. Using a univariate logistic regression model, four parameters were found to be significantly associated with death in the HIV group: sex, APACHE II score on day 1, CMV co-infection, and level of PEEP on day 3 of ARF. In the non-HIV group, corticosteroid use prior to diagnosis of PCP and level of PEEP on day 3 of ARF were found to be the significant parameters. CONCLUSION: The mortality rate in patients with ARF caused by PCP was high. Various variable factors were related to a poor prognosis. For improved survival, multimodality treatments are needed to reduce these risk factors.

Survey of asthma control in Thailand.

OBJECTIVE: The aim of the study was to determine whether asthma management in Thailand is succeeding in achieving the levels of control, specified in national and international asthma guidelines. METHODOLOGY: Adults with asthma in Bangkok, Chiang Mai, Songkhla, and Khon Kaen were interviewed, and we have reported on their asthma severity, morbidity, control, perception of asthma, and healthcare use. RESULTS: A total of 466 asthma sufferers were interviewed. The burden of asthma was high, with 14.8% of respondents being hospitalized for their asthma in the past year. One-quarter of those surveyed had lost workdays as a result of their asthma, and most patients felt that their lifestyle was limited. The majority of respondents had intermittent asthma (62.9%), 10.5% had mild persistent asthma, 17.6% had moderate persistent asthma, and 9.0% had severe persistent asthma; increasing severity was significantly associated with increased emergency healthcare use (P < 0.00001). Asthma sufferers greatly underestimated the severity of their condition. Only 36.0% used reliever medication, and use of inhaled corticosteroids was low at 6.7%. Understanding of the inflammatory basis of asthma was poor. Few patients underwent lung function tests or took peak flow meter readings. CONCLUSIONS: The burden of asthma is high in Thailand, and guidelines are not being followed. Encouraging greater use of inhaled corticosteroids will be an important step towards improving asthma control.