Emergence of Stable Meron Quartets in Twisted Magnets.

The investigation of twist engineering in easy-axis magnetic systems has revealed remarkable potential for generating topological spin textures. Implementing twist engineering in easy-plane magnets, we introduce a novel approach to achieving fractional topological spin textures, such as merons. Through atomistic spin simulations on twisted bilayer magnets, we demonstrate the formation of a stable double Meron pair, which we refer to as the "Meron Quartet" (MQ). Unlike a single pair, the merons within the MQ exhibit exceptional stability against pair annihilation due to the protective localization mechanism induced by the twist that prevents collision of the Meron cores. Furthermore, we showcase that the stability of the MQ can be enhanced by adjusting the twist angle, resulting in an increased resistance to external perturbations such as external magnetic fields. Our findings highlight the twisted magnet as a promising platform for achieving merons as stable magnetic quasiparticles in van der Waals magnets.

Magnon Orbital Nernst Effect in Honeycomb Antiferromagnets without Spin-Orbit Coupling.

Recently, topological responses of magnons have emerged as a central theme in magnetism and spintronics. However, resulting Hall responses are typically weak and infrequent, since, according to present understanding, they arise from effective spin-orbit couplings, which are weaker compared to the exchange energy. Here, by investigating transport properties of magnon orbital moments, we predict that the magnon orbital Nernst effect is an intrinsic characteristic of the honeycomb antiferromagnet and therefore, it manifests even in the absence of spin-orbit coupling. For the electric detection, we propose an experimental scheme based on the magnetoelectric effect. Our results break the conventional wisdom that the Hall transport of magnons requires spin-orbit coupling by predicting the magnon orbital Nernst effect in a system without it, which leads us to envision that our work initiates the intensive search for various magnon Hall effects in generic magnetic systems with no reliance on spin-orbit coupling.

Phospho-Chitooligosaccharides below 1 kDa Inhibit HIV-1 Entry In Vitro.

Despite present antiviral agents that can effectively work against HIV-1 replication, side effects and drug resistance have pushed researchers toward novel approaches. In this context, there is a continued focus on discovering new and more effective antiviral compounds, particularly those that have a natural origin. Polysaccharides are known for their numerous bioactivities, including inhibiting HIV-1 infection and replication. In the present study, phosphorylated chitosan oligosaccharides (PCOSs) were evaluated for their anti-HIV-1 potential in vitro. Treatment with PCOSs effectively protected cells from HIV-1-induced lytic effects and suppressed the production of HIV-1 p24 protein. In addition, results show that PCOSs lost their protective effect upon post-infection treatment. According to the results of ELISA, PCOSs notably disrupted the binding of HIV-1 gp120 protein to T cell surface receptor CD4, which is required for HIV-1 entry. Overall, the results point out that PCOSs might prevent HIV-1 infection at the entry stage, possibly via blocking the viral entry through disruption of virus-cell fusion. Nevertheless, the current results only present the potential of PCOSs, and further studies to elucidate its action mechanism in detail are needed to employ phosphorylation of COSs as a method to develop novel antiviral agents.

Ferrimagnetic spintronics.

Ferrimagnets composed of multiple and antiferromagnetically coupled magnetic elements have attracted much attention recently as a material platform for spintronics. They offer the combined advantages of both ferromagnets and antiferromagnets, namely the easy control and detection of their net magnetization by an external field, antiferromagnetic-like dynamics faster than ferromagnetic dynamics and the potential for high-density devices. This Review summarizes recent progress in ferrimagnetic spintronics, with particular attention to the most-promising functionalities of ferrimagnets, which include their spin transport, spin texture dynamics and all-optical switching.

Dual Role of Chitin as the Double Edged Sword in Controlling the NLRP3 Inflammasome Driven Gastrointestinal and Gynaecological Tumours.

The role of NLRP3 in the tumour microenvironment is elusive. In some cancers, the activation of NLRP3 causes a worse prognosis and in some cancers, NLRP3 increases chances of survivability. However, in many cases where NLRP3 has a protumorigenic role, inhibition of NLRP3 would be a crucial step in therapy. Consequently, activation of NLRP3 would be of essence when inflammation is required. Although many ways of inhibiting and activating NLRP3 in cancers have been discussed before, not a lot of focus has been given to chitin and chitosan in this context. The availability of these marine compounds and their versatility in dealing with inflammation needs to be investigated further in relation with cancers, along with other natural extracts. In this review, the effects of NLRP3 on gastrointestinal and gynaecological cancers and the impact of different natural extracts on NLRP3s with special emphasis on chitin and chitosan is discussed. A research gap in using chitin derivatives as anti/pro-inflammatory agents in cancer treatment has been highlighted.

Potential Cosmetic Active Ingredients Derived from Marine By-Products.

The market demand for marine-based cosmetics has shown a tremendous growth rate in the last decade. Marine resources represent a promising source of novel bioactive compounds for new cosmetic ingredient development. However, concern about sustainability also becomes an issue that should be considered in developing cosmetic ingredients. The fisheries industry (e.g., fishing, farming, and processing) generates large amounts of leftovers containing valuable substances, which are potent sources of cosmeceutical ingredients. Several bioactive substances could be extracted from the marine by-product that can be utilized as a potent ingredient to develop cosmetics products. Those bioactive substances (e.g., collagen from fish waste and chitin from crustacean waste) could be utilized as anti-photoaging, anti-wrinkle, skin barrier, and hair care products. From this perspective, this review aims to approach the potential active ingredients derived from marine by-products for cosmetics and discuss the possible activity of those active ingredients in promoting human beauty. In addition, this review also covers the prospect and challenge of using marine by-products toward the emerging concept of sustainable blue cosmetics.

Distinct handedness of spin wave across the compensation temperatures of ferrimagnets.

Antiferromagnetic spin waves have been predicted to offer substantial functionalities for magnonic applications due to the existence of two distinct polarizations, the right-handed and left-handed modes, as well as their ultrafast dynamics. However, experimental investigations have been hampered by the field-immunity of antiferromagnets. Ferrimagnets have been shown to be an alternative platform to study antiferromagnetic spin dynamics. Here we investigate thermally excited spin waves in ferrimagnets across the magnetization compensation and angular momentum compensation temperatures using Brillouin light scattering. Our results show that right-handed and left-handed modes intersect at the angular momentum compensation temperature where pure antiferromagnetic spin waves are expected. A field-induced shift of the mode-crossing point from the angular momentum compensation temperature and the gyromagnetic reversal reveal hitherto unrecognized properties of ferrimagnetic dynamics. We also provide a theoretical understanding of our experimental results. Our work demonstrates important aspects of the physics of ferrimagnetic spin waves and opens up the attractive possibility of ferrimagnet-based magnonic devices.

Publisher Correction: Distinct handedness of spin wave across the compensation temperatures of ferrimagnets.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Anti-Photoaging and Potential Skin Health Benefits of Seaweeds.

The skin health benefits of seaweeds have been known since time immemorial. They are known as potential renewable sources of bioactive metabolites that have unique structural and functional features compared to their terrestrial counterparts. In addition, to the consciousness of green, eco-friendly, and natural skincare and cosmetics products, their extracts and bioactive compounds such as fucoidan, laminarin, carrageenan, fucoxanthin, and mycosporine like amino acids (MAAs) have proven useful in the skincare and cosmetic industries. These bioactive compounds have shown potential anti-photoaging properties. Furthermore, some of these bioactive compounds have been clinically tested and currently available in the market. In this contribution, the recent studies on anti-photoaging properties of extracts and bioactive compounds derived from seaweeds were described and discussed.

Muscle Protein Hydrolysates and Amino Acid Composition in Fish.

Fish muscle, which accounts for 15%-25% of the total protein in fish, is a desirable protein source. Their hydrolysate is in high demand nutritionally as a functional food and thus has high potential added value. The hydrolysate contains physiologically active amino acids and various essential nutrients, the contents of which depend on the source of protein, protease, hydrolysis method, hydrolysis conditions, and degree of hydrolysis. Therefore, it can be utilized for various industrial applications including use in nutraceuticals and pharmaceuticals to help improve the health of humans. This review discusses muscle protein hydrolysates generated from the muscles of various fish species, as well as their amino acid composition, and highlights their functional properties and bioactivity. In addition, the role of the amino acid profile in regulating the biological and physiological activities, nutrition, and bitter taste of hydrolysates is discussed.

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates.

Developing peptide-based drugs are very promising to address many of the lifestyle mediated diseases which are prevalent in a major portion of the global population. As an alternative to synthetic peptide-based drugs, derived peptides from natural sources have gained a greater attention in the last two decades. Aquatic organisms including plants, fish and shellfish are known as a rich reservoir of parent protein molecules which can offer novel sequences of amino acids in peptides, having unique bio-functional properties upon hydrolyzing with proteases from different sources. However, rather than exploiting fish and shellfish stocks which are already under pressure due to overexploitation, the processing discards, regarded as secondary raw material, could be a potential choice for peptide based therapeutic development strategies. In this connection, we have attempted to review the scientific reports in this area of research that deal with some of the well-established bioactive properties, such as antihypertensive, anti-oxidative, anti-coagulative, antibacterial and anticarcinogenic properties, with reference to the type of enzymes, substrate used, degree of particular bio-functionality, mechanism, and wherever possible, the active amino acid sequences in peptides. Many of the studies have been conducted on hydrolysate (crude mixture of peptides) enriched with low molecular bioactive peptides. In vitro and in vivo experiments on the potency of bioactive peptides to modulate the human physiological functions beneficially have demonstrated that these peptides can be used in the prevention and treatment of non-communicable lifestyle mediated diseases. The information synthesized under this review could serve as a point of reference to drive further research on and development of functionally active therapeutic natural peptides. Availability of such scientific information is expected to open up new zones of investigation for adding value to underutilized secondary raw materials, which in turn paves the way for sustainability in fish processing. However, there are significant challenges ahead in exploring the fish waste as a source of bioactive peptides, as it demands more studies on mechanisms and structure-function relationship understanding as well as clearance from regulatory and statutory bodies before reaching the end user in the form of supplement or therapeutics.

Recent developments of natural antimicrobials and antioxidants on fish and fishery food products.

Fish and fishery products (FFP) are highly perishable due to their high nutritional value and moisture content. The spoilage is mainly caused by microorganisms and chemical reactions, especially lipid oxidation, leading to losses in quality and market value. Microbiological and lipid deteriorations of fishery-derived products directly lower their nutritive value and pose the risk of toxicity for human health. Increasing demand for safe FFP brings about the preservation using additives from natural origins without chemical additives due to their safety and strict regulation. Antimicrobials and antioxidants from natural sources have exhibited an excellent control over the growth of microorganisms causing fish spoilage via different mechanisms. They also play a major role in retarding lipid oxidation by acting at various stages of oxidation. Antimicrobials and antioxidants from natural sources are usually regarded as safe with no detrimental effects on the quality attributes of FFP. This review provides recent literature on the different antioxidant and antimicrobial agents from natural sources, focusing on microbial and oxidative spoilage mechanisms, their inhibition system, and their applications to retard spoilage, maintain safety, and extend the shelf life of FFP. Their applications and benefits have been revisited.

Enhanced Magnon-Photon Coupling at the Angular Momentum Compensation Point of Ferrimagnets.

We theoretically show that the coupling between magnons in an antiferromagnetically coupled ferrimagnet and microwave photons in a cavity is largely enhanced at the angular momentum compensation point (T_{A}) when T_{A} is distinct from the magnetization compensation point. The origin of the enhanced magnon-photon coupling at T_{A} is identified as the antiferromagnetic spin dynamics combined with a finite magnetization. Moreover, we show that strong magnon-photon coupling can be achieved at high excitation frequency in a ferrimagnet, which is challenging to achieve for a ferromagnet due to low magnon frequency and for an antiferromagnet due to weak magnon-photon coupling. Our results will invigorate research on magnon-photon coupling by proposing ferrimagnets as a versatile platform that offers advantages of both ferromagnets and antiferromagnets.

SU(3) Topology of Magnon-Phonon Hybridization in 2D Antiferromagnets.

Magnon-phonon hybrid excitations are studied theoretically in a two-dimensional antiferromagnet with an easy axis normal to the plane. We show that two magnon bands and one phonon band are intertwined by the magnetoelastic coupling through a nontrivial SU(3) topology, which can be intuitively perceived by identifying a skyrmion structure in the momentum space. Our results are insensitive to lattice details and generally applicable to two-dimensional antiferromagnets. We show this by developing a continuum theory as the long-wavelength approximation to the tight-binding model. The theoretical results can be probed by measuring the thermal Hall conductance as a function of the temperature and the magnetic field. We envision that the magnetoelastic coupling in antiferromagnets can be a promising venue in search of various topological excitations, which cannot be found in magnetic or elastic models alone.

Topological Magnon-Phonon Hybrid Excitations in Two-Dimensional Ferromagnets with Tunable Chern Numbers.

We theoretically investigate magnon-phonon hybrid excitations in two-dimensional ferromagnets. The bulk bands of hybrid excitations, which are referred to as magnon polarons, are analytically shown to be topologically nontrivial, possessing finite Chern numbers. We also show that the Chern numbers of magnon-polaron bands and the number of band-crossing lines can be manipulated by an effective magnetic field. For experiments, we propose to use the thermal Hall conductivity as a probe of the finite Berry curvatures of magnon-polarons. Our results show that a simple ferromagnet on a square lattice supports topologically nontrivial magnon polarons, generalizing topological excitations in conventional magnetic systems.

Tunable Magnonic Thermal Hall Effect in Skyrmion Crystal Phases of Ferrimagnets.

We theoretically study the thermal Hall effect by magnons in skyrmion crystal phases of ferrimagnets in the vicinity of the angular momentum compensation point (CP). To this end, we start by deriving the equation of motion for magnons in the background of an arbitrary equilibrium spin texture, which gives rise to the fictitious electromagnetic field for magnons. As the net spin density varies, the resultant equation of motion interpolates between the relativistic Klein-Gordon equation at the CP and the nonrelativistic Schrödinger-like equation away from it. In skyrmion crystal phases, the right- and the left-circularly polarized magnons, with respect to the order parameter, are shown to form the Landau levels separately within the uniform skyrmion-density approximation. For an experimental proposal, we predict that the magnonic thermal Hall conductivity changes its sign when the ferrimagnet is tuned across the CP, providing a way to control heat flux in spin-caloritronic devices on the one hand and a feasible way to detect the CP of ferrimagnets on the other hand.

Low Magnetic Damping of Ferrimagnetic GdFeCo Alloys.

We investigate the Gilbert damping parameter α for rare earth (RE)-transition metal (TM) ferrimagnets over a wide temperature range. Extracted from the field-driven magnetic domain-wall mobility, α was as low as the order of 10^{-3} and was almost constant across the angular momentum compensation temperature T_{A}, starkly contrasting previous predictions that α should diverge at T_{A} due to a vanishing total angular momentum. Thus, magnetic damping of RE-TM ferrimagnets is not related to the total angular momentum but is dominated by electron scattering at the Fermi level where the TM has a dominant damping role. This low value of the Gilbert damping parameter suggests that ferrimagnets can serve as versatile platforms for low-dissipation high-speed magnetic devices.

Fast domain wall motion in the vicinity of the angular momentum compensation temperature of ferrimagnets.

Antiferromagnetic spintronics is an emerging research field which aims to utilize antiferromagnets as core elements in spintronic devices. A central motivation towards this direction is that antiferromagnetic spin dynamics is expected to be much faster than its ferromagnetic counterpart. Recent theories indeed predicted faster dynamics of antiferromagnetic domain walls (DWs) than ferromagnetic DWs. However, experimental investigations of antiferromagnetic spin dynamics have remained unexplored, mainly because of the magnetic field immunity of antiferromagnets. Here we show that fast field-driven antiferromagnetic spin dynamics is realized in ferrimagnets at the angular momentum compensation point TA. Using rare earth-3d-transition metal ferrimagnetic compounds where net magnetic moment is nonzero at TA, the field-driven DW mobility is remarkably enhanced up to 20 km s-1 T-1. The collective coordinate approach generalized for ferrimagnets and atomistic spin model simulations show that this remarkable enhancement is a consequence of antiferromagnetic spin dynamics at TA. Our finding allows us to investigate the physics of antiferromagnetic spin dynamics and highlights the importance of tuning of the angular momentum compensation point of ferrimagnets, which could be a key towards ferrimagnetic spintronics.

Nonlocal Spin Transport Mediated by a Vortex Liquid in Superconductors.

Departing from the conventional view on superconducting vortices as a parasitic source of dissipation for charge transport, we propose to use mobile vortices as topologically stable information carriers. To this end, we start by constructing a phenomenological theory for the interconversion between spin and vorticity, a topological charge carried by vortices, at the interface between a magnetic insulator and a superconductor, by invoking the interfacial spin Hall effect therein. We then show that a vortex liquid in superconductors can serve as a spin-transport channel between two magnetic insulators by encoding spin information in the vorticity. The vortex-mediated nonlocal signal between the two magnetic insulators is shown to decay algebraically as a function of their separation, contrasting with the exponential decay of the quasiparticle-mediated spin transport. We envision that hydrodynamics of topological excitations, such as vortices in superconductors and domain walls in magnets, may serve as a universal framework to discuss long-range transport properties of ordered materials.

Spin-Torque-Biased Magnetic Strip: Nonequilibrium Phase Diagram and Relation to Long Josephson Junctions.

Spin-torque-biased magnetic dynamics in an easy-plane ferromagnet (EPF) is theoretically studied in the presence of a weak in-plane anisotropy. While this anisotropy spoils U(1) symmetry, thereby quenching the conventional spin superfluidity, we show that the system instead realizes a close analog of a long Josephson junction (LJJ) model. The traditional magnetic-field and electric-current controls of the latter map, respectively, onto the symmetric and antisymmetric combinations of the out-of-plane spin torques applied at the ends of the magnetic strip. This suggests an alternative route towards realizations of superfluidlike transport phenomena in insulating magnetic systems. We study a spin-torque-biased phase diagram, providing an analytical solution for static multidomain phases in the EPF. We adapt an existing self-consistency method for the LJJ to develop an approximate solution for the EPF dynamics. The LJJ-EPF mapping has the potential for producing applications with superconductor-based circuit functionality at elevated temperatures. The results apply equally to antiferromagnets with suitable effective free energy in terms of the Néel order instead of in-plane magnetization.